Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2841 - 2850 of 3476
2841
Memantine attenuates delayed vasospasm after experimental subarachnoid hemorrhage via modulating endothelial nitric oxide synthase

CY Huang, LC Wang, YS Shan, CH Pan, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan , 23 June 2015

Neuroscience

Key words: memantine, nitric oxide synthase, subarachnoid hemorrhage, vasospasm

Organism: Rat

Tissue: Brain

Pathological State: Vasospasm

2842
STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pencik, Michaela Schlederer, Wolfgang Gruber, Christine Unger, Steven M Walker, Athena Chalaris, Isabelle J Marié, Melanie R Hassler, Tahereh Javaheri, Osman Aksoy, Jaine K Blayney, Nicole Prutsch, Anna Skucha, Merima Herac, Oliver H Krämer, Peter Mazal, Florian Grebien, Gerda Egger, Valeria Poli, Wolfgang Mikulits et al

Nature Communications (Nature) Austria, UK, Germany, USA, Italy, Sweden , 22 June 2015

Oncology

Key words: STAT3 and p14ARF expression, PI3K–AKT–mTOR signalling pathway, ARF–Mdm2–p53 tumour suppressor axis

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

2843
The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia

Stephanie M Rangel, Maureen H Diaz, Claire A Knoten, Angelica Zhang, Alan R Hauser

PLoS Pathogens (PLOS) USA , 19 June 2015

Pulmonology

Key words: Pneumocytes, pneumonia, bacterial pathogens, pseudomonas aeruginosa, pulmonary imaging, cell staining, phagocytes, blood

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

2844
Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

Jan-Renier AJ Moonen, Ee Soo Lee, Marc Schmidt, Monika Maleszewska, Jasper A Koerts, Linda A Brouwer, Theo G Van Kooten, Marja JA Van Luyn, Clark J Zeebregts, Guido Krenning, Martin C Harmsen

Cardiovascular Research (Oxford University Press) The Netherlands, Germany , 17 June 2015

Cardiology

Key words: LRRFIP1, EMT, Wnt/β-catenin signaling, β-catenin destruction complex, Reverse EMT

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

2845
Left Shift 1+ flag for the detection of band neutrophils: interlaboratory variations and recommendations for the routine laboratory

F WEERKAMP, P H TAAL, B A De BOER and ON BEHALF OF THE ADdifVIA WORKING GROUP

International Journal of Laboratory Hematology (Wiley) The Netherlands , 16 June 2015

Hematology

Key words: Differential leukocyte count, left shift flag, band neutrophils, routine laboratory

Organism: Human

Cell Line: Blood

2846
Image analysis for accurately counting CD4+ and CD8+ T cells in human tissue

Kurt Diema, Amalia Magaret, Alexis Klock, Lei Jina, Jia Zhu, Lawrence Corey

Journal of Virological Methods (Elsevier) USA , 12 June 2015

Virology

Key words: Cell counting, immunohistochemistry (IHC), software cell counting, HSV-2, cellProfiler

Organism: Human

Tissue: Penis

Pathological State: Virus Infection

2847
298 MAST CELLS ARE ABUNDANT IN CUTANEOUS T‐CELL LYMPHOMAS AND CORRELATE WITH DISEASE STAGE

P Gorniak, B Budziszewska, B Pula, M Wasylecka, K Borg, G Nowak, H Makuch - Lasica, E Lech - Maranda, K Warzocha, P Juszczynski

Hematological Oncology (Wiley) Poland , 09 June 2015

Oncology

Key words: Cerebral ischemia–reperfusion injury, oxidative stress, apoptosis, superoxide, NADPH oxidase

Organism: Human

Tissue: Lymphoid Tissue

2848
Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

Tung-Hung Su, Chung-Wai Shiau, Ping Jao, Chen-Hua Liu, Chun-Jen Liu, Wei-Tien Tai, Yung-Ming Jeng, Hung-Chih Yang, Tai-Chung Tseng, Hsiang-Po Huang, Huei-Ru Cheng, Pei-Jer Chen, Kuen-Feng Chen, Jia-Horng Kao, Ding-Shinn Chen

PNAS (PNAS) Taiwan , 09 June 2015

Cell Biology

Key words: Hepatic stellate, cell STAT3 SHP-1, hepatitis B, liver fibrosis

Pathological State: Liver Fibrosis

2849
ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors

Liem T Nguyen, Maria S Tretiakova, Mark R Silvis, Jared Lucas, Olga Klezovitch, Ilsa Coleman, Hamid Bolouri, Vassily I Kutyavin, Colm Morrissey, Lawrence D True, Peter S Nelson, Valeri Vasioukhin

Cancer Cell (Cell Press) USA , 08 June 2015

Oncology

Key words: Prostate cancer, actin cytoskeleton

Organism: Human

Tissue: Prostate

Pathological State: Cancer

2850
CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models

JF Xu, XH Pan, SJ Zhang, C Zhao, BS Qiu, HF Gu, JF Hong, L Cao, Y Chen, B Xia, Q Bi, YP Wang

Oncotarget (Impact Journals) China , 08 June 2015

Oncology

Key words: osteosarcoma, CD47, antibody, immunotherapy

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

Results 2841 - 2850 of 3476

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