Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2801 - 2810 of 3476
2801
Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage

Patricia Aparicio-Domingo, Monica Romera-Hernandez, Julien J Karrich, Ferry Cornelissen, Natalie Papazian, Dicky J Lindenbergh-Kortleve, James A Butler, Louis Boon, Mark C Coles, Janneke N Samsom, Tom Cupedo

Journal of Experimental Medicine (Rockefeller University Press) The Netherlands, UK , 21 September 2015

Stem Cell Research

Key words: Type 3 innate lymphoid cells, intestinal epithelial stem cells, tissue damage

Organism: Mouse

Tissue: Intestine, Colon

2802
Bone marrow micro-environmental CD4+ and CD8+ lymphocyte infiltration patterns define overall- and progression free survival in standard risk Multiple Myeloma – an analysis from the Austrian Myeloma Registry

Wolfgang Willenbacher, Ella Willenbacher, Claudia Zelle-Rieser, Rainer Biedermann, Roman Weger, Karin Jöhrer, Andrea Brunner

Leukemia and Lymphoma (Taylor and Francis) Austria , 19 September 2015

Oncology

Key words: Bone marrow, lymphocite infiltration, myeloma

Organism: Human

Tissue: Bone

Pathological State: Cancer

2803
Quantitative functional MRI in a clinical orthotopic model of pancreatic cancer in immunocompetent Lewis rats

Zhuoli Zhang, Linfeng Zheng, Weiguo Li, Andrew C Gordon, Yi Huan, Junjie Shangguan, Daniel Procissi, David J Bentrem, Andrew C Larson

American Journal of Translational Research (e-Century Publishing Corporation) USA, China , 15 September 2015

Oncology

Key words: Magnetic resonance imaging, imaging biomarker, pancreatic cancer, immunocompetent Lewis rats

Organism: Rat

Tissue: Pancreas

Pathological State: Cancer

2804
Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer

CJ Yang, YP Liu, HY Dai, YL Shiue, CJ Tsai, MS Huang, YT Yeh

Oncotarget (Impact Journals) Taiwan , 15 September 2015

Oncology

Key words: HDAC6, NF-κB, MMP2, metastasis, lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

2805
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences

Aswin Mangerich, Malgorzata Debiak, Matthias Birtel, Viviane Ponath, Frank Balszuweit, Kirsten Lex, Rita Martello, Waltraud Burckhardt-Boer, Romano Strobelt, Markus Siegert, Horst Thiermanb, Dirk Steinritz, Annette Schmidt, Alexander Bürkle

Toxicology Letters (Elsevier) Germany , 14 September 2015

Toxicology

Key words: Poly(ADP-ribose), PARP inhibitors, sulfur mustard, nitrogen mustard, genotoxicity, HaCaT, mass spectrometry, micronucleus

Organism: Human

Cell Line: HaCaTs (human keratinocyte cell line )

2806
Efficient therapy of ischaemic lesions with VEGF121-fibrin in an animal model of systemic sclerosis.

Allipour Birgani S, Mailänder M, Wasle I, Dietrich H, Gruber J, Distler O, Sgonc R

Annals of the Rheumatic Diseases (BMJ Journals) Austria, Switzerland , 11 September 2015

Rheumatology

Key words: Outcomes research, systemic sclerosis, treatment

Organism: Bird

Tissue: Skin

Pathological State: Systemic Sclerosis

2807
The ß-catenin signaling pathway induces aggressive potential in breast cancer by up-regulating the chemokine CCL5

Rika Yasuhara, Tarou Irié, Kenya Suzuki, Terumasa Sawada, Noriko Miwa, Akiko Sasaki, Yuko Tsunoda, Seigo Nakamura, Kenji Mishima

Experimental Cell Research (Elsevier) Japan , 10 September 2015

Oncology

Key words: ß-Catenin, metastasis, breast cancer, cytokines, CCL5

Organism: Human

Tissue: Breast

Pathological State: Cancer

2808
Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

S Kaduwal, WJ Jeong, JC Park, KH Lee, YM Lee, SH Jeon, YB Lim, DS Min, KY Choi

Oncotarget (Impact Journals) South Korea , 05 September 2015

Oncology

Key words: Sur8, Ras, PI3K, cell migration, metastasis

Organism: Human

Tissue: Skin

Pathological State: Cancer

2809
The IκB kinase inhibitor ACHP strongly attenuates TGF β1‐induced myofibroblast formation and collagen synthesis

Masum M Mia, Ruud A Bank

Journal of Cellular and Molecular Medicine (Wiley) The Netherlands , 04 September 2015

Cell Biology

Key words: Fibrosis, collagen, myofibroblasts, fibronectin, lysyl hydroxylase

Organism: Human

Cell Line: HDFa and HLFa Fibroblasts

2810
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

Christoph Geisenberger, Andreas Mock, Rolf Warta,Carmen Rapp, Christian Schwager, Andrey Korshunov, Ann-Katrin Nied, David Capper, Benedikt Brors, Christine Jungk, David Jones, V Peter Collins, Koichi Ichimura, L Magnus Bäcklund, Elena Schnabel, Michel Mittelbron, Bernd Lahrmann, Siyuan Zheng, Roel G W Verhaak, Niels Grabe, Stefan M Pfister, Christian Hartmann, Andreas von Deimling, Jürgen Debus, Andreas Unterberg, Amir Abdollahi, Christel Herold-Mende

Acta Neuropathologica (Springer) Germany, UK, Japan, Sweden, USA , 01 September 2015

Pathology

Key words: Glioblastoma, molecular profiling, microglia, long-term survival, short-term survival

Organism: Human

Tissue: Brain

Pathological State: Cancer

Results 2801 - 2810 of 3476

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