Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2331 - 2340 of 3476
2331
Expression and modulation of S100A4 protein by human mast cells

Rossana Domenis, David Pilutti, Maria Orsaria, Stefania Marzinotto, Veronica Candotti, Giulia Bosisio, Michela Bulfoni, Maria Elisabetta Ruaro, Carla Di Loreto, Vincenzo Della Mea, Eleonora Toffoletti, Ambrogio PLondero, Laura Mariuzzi, Giorgia Gri

Cellular Immunology (Elsevier) Italy , 04 August 2018

Immunology

Key words: Immunofluorescence Tryptase Metalloproteinase Mast cells biology siRNA

Organism: Human

Tissue: Skin

Pathological State: Bladder Cyst, Crohn's Disease, Cancer

2332
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine

Chang‐Bin Liu De‐Gang Yang Xin Zhang Wen‐Hao Zhang Da‐Peng Li Chao Zhang Chuan Qin Liang‐Jie Du Jun Li Feng Gao Jie Zhang Zhen‐Tao Zuo Ming‐Liang Yang Jian‐Jun Li

CNS Neuroscience and Therapeutics (Wiley) China , 03 August 2018

Neuroscience

Key words: canine model, diffusion tensor imaging, gray matter, pathological degeneration, spinal cord injury, white matter

Organism: Dog

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2333
Crumpled Aluminum Hydroxide Nanostructures as a Microenvironment Dysregulation Agent for Cancer Treatment

MI Lerner, G Mikhaylov, AA Tsukanov, Aleksandr S Lozhkomoev, Elazar Gutmanas, Irena Gotman, Andreja Bratovs, Vito Turk‡ Boris Turk, Sergey G Psakhye, and Olga Vasiljeva

Nano Letters (ACS Publications) Russia, Israel, Slovenia , 02 August 2018

Nanomedicine

Key words: aluminum hydroxide, cancer treatment, Crumpled nanosheets, ion balance, molecular dynamics simulation, tumor microenvironment

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

2334
Plk1 overexpression suppresses tumor development by inducing chromosomal instability

Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres and Rocío Sotillo

Nature Communications (Nature) Spain, Germany, UK , 01 August 2018

Oncology

Key words: Cancer, Cell biology

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

2335
SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy

LawrenceHuangabJen-ShiuChiang ChiaucMei-LienChengcWai-TaoChanaChuen-BinJiangadSzu-WenChangaChun-YanYeungaeHung-ChangLee

Pediatrics and Neonatology (Elsevier) Taiwan , 26 July 2018

Gastroenterology

Key words: SCID, cytokines, fluorouracil, mucositis, probiotics

Organism: Mouse

Tissue: Intestine

Pathological State: Diarrhea

2336
Trehalose to cryopreserve human pluripotent stem cells

Aikaterini Ntaia , Alberto La Spadab , Pasquale De Blasioa , Ida Biunno

Stem Cell Research (Elsevier) Italy , 25 July 2018

Stem Cell Research

Key words: Cryopreservation, Trehalose, Pluripotent stem cells

Organism: Human

Cell Line: hESCs, lt-NES, hiPSCs

2337
Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells

YT Wu, KT Chi, YW Lan, JC Chan, YS Ma, YH Wie

Free Radical Research (Taylor and Francis) Taiwan , 23 July 2018

Stem Cell Research

Key words: Adipogenesis, antioxidant defence, human mesenchymal stem cells, insulin resistance, mitochondrial bioenergetics, Sirt3

Organism: Human

Cell Line: adiposederived human mesenchymal stem cells

2338
Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells

Anja Weber,Helmut Klocker,Herbert Oberacher,Erich Gnaiger,Hannes Neuwirt,Natalie Sampson and Iris E Eder

International Journal of Molecular Sciences (MDPI) Austria , 21 July 2018

Oncology

Key words: Na+-dicarboxylate transporter, acidic tumor microenvironment, mitochondria, oxidative phosphorylation, prostate cancer, succinate

Organism: Human

Pathological State: Cancer

Cell Line: LNCaP, PC-3 (prostate cancer cell lines)

2339
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe, Idil Orhon, Cecilia Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, Robert P Coppes, Nikolai Engedal, Muriel Mari and Fulvio Reggiori

Autophagy (Taylor and Francis) The Netherlands , 20 July 2018

Cell Biology

Key words: Autophagy, Golgi, bafilomycin A1, degradative compartments, fusion, lysosomal degradation, lysosomal inhibitors

Organism: Human

Pathological State: Cancer

Cell Line: U2OS (Osteosarcoma cell line), HeLa cells

2340
Prognostic and predictive values of immune infiltrate in patients with head and neck squamous cell carcinoma

Xue-MeiZhang Ling-JunSong JuanShenHao YueYa-QinHanChen LingYangShi YunLiuJia WenDengYue JiangGuo HuiFu

Human Pathology (Elsevier) China , 20 July 2018

Oncology

Key words: Head and Neck Squamous Cell Carcinoma, Immunoscore, Prognosis and Predictive, Tumor Infiltrating Lymphocytes

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

Results 2331 - 2340 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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