Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2291 - 2300 of 3476
2291
Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis

Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy C Mottram, Simon L Croft, Paul M Kaye

Wellcome Open Research (Wellcome Open Research) UK , 29 October 2018

Parasitology

Key words: Leishmania, infection, host response, transcriptomics, immunopathology

Organism: Mouse

Tissue: Spleen, Liver

Pathological State: Leishmaniasis

2292
Azo-based small molecular hypoxia responsive theranostic for tumor-specific imaging and therapy

Ying Zhoua, Mrinmoy Maitib, Amit Sharmac, Miae Won, Le Yu, Lan Xi, Miao, Jinwoo Shin, Arup Podder, Kondapa Naidu Bobba, Jiyou Han, Sankarprasad Bhuniya, Jong Seung Kim

Journal of Controlled Release (Elsevier) China, India, South Korea , 28 October 2018

Oncology

Key words: molecular hypoxia, theranostic, tumor-specific imaging,

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2293
PI3K: A master regulator of brain metastasis‐promoting macrophages/microglia

Raquel Blazquez Darius Wlochowitz Alexander Wolff Stefanie Seitz Astrid Wachter Julia Perera‐Bel Annalen Bleckmann Tim Beißbarth Gabriela Salinas Markus J Riemenschneider Martin Proescholdt Matthias Evert Kirsten Utpatel Laila Siam Bawarjan Schatlo Marko Balkenhol Christine Stadelmann Hans‐Ulrich Schildhaus Ulrike Korf Eileen Reinz Stefan Wiemann Elena Vollmer Mathias Schulz Uwe Ritter Uwe K Hanisch Tobias Pukrop

GLIA (Wiley) Germany , 25 October 2018

Oncology

Key words: Astrocytes, BKM120, brain metastasis, macrophages, microglia, PI3K, RPPA

Organism: Mouse

Pathological State: Cancer

Cell Line: Monocyte‐derived macrophages (MDMs)

2294
Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Wei-TaChen, Wei-Tse Hsu, Meng-Hua Yen, Chun A Changou, Chia-Li Han, Yu-Ju Chen, Ji-Yen Cheng, Tzu-Hao Chang, Oscar Kuang-Sheng Lee, Jennifer Hui-Chun Ho

Biomaterials (Elsevier) Taiwan , 23 October 2018

Stem Cell Research

Key words: β-catenin, Cardiovascular, Laminar shear, Mesenchymal stem cells, Wnt

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

2295
Gene expression profiling in a mouse model of Dravet syndrom

Nicole AHawkins, Jeffrey DCalhoun, Alexandra MHuffman, Jennifer AKearney

Experimental Neurology (Elsevier) USA , 19 October 2018

Neuroscience

Key words: Epilepsy, Epileptic encephalopathy, Gene expression, RNA-seq, Seizure, Voltage-gated sodium channel

Organism: Mouse

Tissue: Brain

Pathological State: Dravet Syndrome

2296
Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation

Janaina M Alves, Antonio H Martins, Claudiana Lameu, Talita Glaser, Nawal M Boukli, Vinicius Bassaneze, Rafael Dariolli, Isis C Nascimento, Poliana C M Martins, Héllio D N de Souza, José Eduardo Krieger, Dulce E Casarini, Vicencia M Sales, João B Pesquero, Henning Ulrich

Stem Cell Reviews and Reports (Springer) USA, Brazil , 18 October 2018

Stem Cell Research

Key words: Mouse myoblast differentiation, Muscle repair, Kinin-B2 receptor, HOE-140

Organism: Mouse

Cell Line: Myoblast cell line - C2C12 Cells

2297
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

Mera vCohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit

CELL (Cell Press) Israel, Austria, Sweden , 11 October 2018

Cell Biology

Key words: immune systemsingle-cell RNA sequencinglungbasophilsalveolar macrophagescellular interactiondevelopmentsignaling

Organism: Mouse

Tissue: Lung

2298
Early Immunologic Response of Irreversible Electroporation versus Cryoablation in a Rodent Model of Pancreatic Cancer

Sarah B White, MD, MS, FSIR, Zhouli Zhang, MD, PhD, Jeane Chen, PhD, Venkateswara R Gogineni, PhD, and Andrew C Larson, PhD

Journal of Vascular and Interventional Radiology (Elsevier) USA , 11 October 2018

Immunology

Key words: irreversible electroporation, Cryoablation, Pancreatic Cancer

Organism: Mouse

Pathological State: Cancer

Cell Line: PANC-2 (Pancreatic cancer cell line)

2299
Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon

Chia-Hsin Chen, Yi-Hsiung Lin, Chung-Hwan Chen, Yan-Hsiung Wang, Ming-Long Yeh, Tsung-Lin Cheng, Chau-Zen Wang

PLoS One (PLOS) Taiwan , 11 October 2018

Cell Biology

Key words: Tendons, Collagens, Gene expression, Stiffness, Vibration, Mechanical properties, Enzyme-linked immunoassays, Polymerase chain reaction

Organism: Rat

2300
Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD

Cell Host and Microbe (Cell Press) USA , 10 October 2018

Immunology, Microbiology

Key words: glycosylation, sepsis, neuraminidase, Toll-like receptor 4, alkaline phosphatase, Ashwell-Morell receptor, lipopolysaccharide, inflammation

Organism: Mouse

Tissue: Liver

Pathological State: Sepsis

Results 2291 - 2300 of 3476

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