Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2271 - 2280 of 3476
2271
CXCL5 as regulator of neutrophil function in cutaneous melanoma

A Forsthuber, K Lipp, L Andersen, S Ebersberger, O Grana-Castro, W Ellmeier, P Petzelbauer, BM Lichtenberger, R Loewe

Journal of Investigative Dermatology (Elsevier) Austria, Germany, Spain , 04 December 2018

Oncology, Dermatology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

2272
Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

Bing Song, Su-Hong Park, Jonathan C Zhao, Ka-wing Fong, Shangze Li, Yongik Lee, Yeqing A Yang, Subhasree Sridhar, Xiaodong Lu, Sarki A Abdulkadir, Robert L Vessella, Colm Morrissey, Timothy M Kuzel, William J Catalona, Ximing J Yang, and Jindan Yu

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, China , 04 December 2018

Oncology

Key words: Genetics, Oncology, Prostate cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

2273
Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DC

Stefan Schierer, Christian Ostalecki, Elisabeth Zinser, Ricarda Lamprecht, Bianca Plosnita, Lena Stich, Jan Dörrie, ProfileManfred B Lutz, ProfileGerold Schuler, ProfileAndreas S Baur

Life Science () Germany, Austria , 03 December 2018

Immunology

Key words: Medical Research, Immunology

Organism: Human, Mouse

Cell Line: Monocyte-derived dentritic cells

2274
Elevated Serum Interleukin-8 Level Correlates with Cancer-Related Cachexia and Sarcopenia: An Indicator for Pancreatic Cancer Outcomes

Ya-Chin Hou, Chih-Jung Wang, Ying-Jui Chao, Hao-Yun Chen, Hao-Chen Wang, Hui-Ling Tung, Jung-Ting Lin and Yan-Shen Shan

Journal of Clinical Medicine (MDPI) Taiwan , 01 December 2018

Oncology

Key words: pancreatic cancer, cancer cachexia, sarcopenia, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

2275
Freshwater cyanotoxin cylindrospermopsin has detrimental stage-specific effects on hepatic differentiation from human embryonic stem cells

Tereza Vanova, Jan Raska, Pavel Babica, Iva Sovadinova, Michaela Kunova Bosakova, Petr Dvorak Ludek Blaha, Vladimir Rotrekl

Toxicological Sciences (Oxford University Press) Czech Republic , 30 November 2018

Stem Cell Research

Key words: cylindrospermopsin, hepatic differentiation, human embryonic stem cells, liver, cyanotoxin

Organism: Human

Cell Line: Human embryonic stem cell (hESCs)

2276
Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1β-Related NLRP3 Inflammasome Activation

Bour-Jr Wang, Hui-Wen Chiu, Yong-Lin Lee, Chia-Yi Li, Ying-Jan Wang, and Yu-Hsuan Lee

Journal of Clinical Medicine (MDPI) Taiwan , 27 November 2018

Allergy Research

Key words: Hexavalent chromium, pterostilbene, endoplasmic reticulum stress, inflammatory cytokines, NLRP3 inflammasome, allergic contact dermatitis

Organism: Mouse

Tissue: Skin

Pathological State: Dermatitis

2277
ONECUT2 Is a Targetable Master Regulator of Lethal Prostate Cancer That Suppresses the Androgen Axis

Mirja Rotinen, Sungyong You, Julie Yang, Simon G Coetzee, Mariana Reis-Sobreiro, Wen-Chin Huang, Fangjin Huang, Xinlei Pan, Alberto Yáñez, Dennis J Hazelett, Chia-Yi Chu, Kenneth Steadman, Colm M Morrissey, Peter S Nelson, Eva Corey, Leland W K Chung, Stephen J Freedland, Dolores Di Vizio, Isla P Garraway, Ramachandran Murali, Beatrice S Knudsen & Michael R Freeman

Nature Medicine (Nature) USA, Taiwan , 26 November 2018

Oncology

2278
Immune Cell and Cell Cluster Phenotyping, Quantitation, and Visualization Using In Silico Multiplexed Images and Tissue Cytometry

Kim RM Blenman, Marcus W Bosenberg

Cytometry Part A (Wiley) USA , 23 November 2018

Cytometry

Key words: immune cells, cell clusters, quantitative imaging, multiplexed histology, tissue cytometry, TissueFAXS in silico analysis, FFPE

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

2279
PD-L1 expression and the prognostic significance in gastric cancer: a retrospective comparison of three PD-L1 antibody clones (SP142, 28–8 and E1L3N)

Jing Ma, Jianhui Li, Meirui Qian, Weili Han, Miaomiao Tian, Zengshan Li, Zhe Wang, Shuixiang He and Kaichun Wu

Diagnostic Pathology (Springer) China , 21 November 2018

Oncology

Key words: Programmed cell death ligand 1, Immunohistochemistry, H-score, Multiplexed immunofluorescence

Organism: Human

Tissue: Stomach

Pathological State: Cancer

2280
MicroRNA-451a overexpression induces accelerated neuronal differentiation of Ntera2/D1 cells and ablation affects neurogenesis in microRNA-451a-/- mice

Christa Trattnig, Muammer Üçal, Carmen Tam-Amersdorfer, Angela Bucko, Ulrike Zefferer, Gerda Grünbacher, Markus Absenger-Novak, Kristin Anna Öhlinger, Klaus Kraitsy, Daniel Hamberger, Ute Schaefer, Silke Patz

PLoS One (PLOS) Austria , 21 November 2018

Neuroscience

Key words: Neuronal differentiation, Neurites, Cell differentiation, Neurospheres, MicroRNAs, Neural networks, Fluorescence microscopy, Nestin

Organism: Mouse

Tissue: Brain

Results 2271 - 2280 of 3476

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