Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3476 papers published)

Results 2251 - 2260 of 3476
2251
Dynamic changes in intramedullary pressure 72 hours after spinal cord injury

Xin Zhang, Chang-Bin Liu, De-Gang Yang, Chuan Qin, Xue-Chao Dong, Da-Peng Li, Chao Zhang, Yun Guo, Liang-Jie Du, Feng Gao, Ming-Liang Yang PhD, Jian-Jun Li

Neural Regeneration Research (Publishing House of Neural Regeneration Research) China , 23 January 2019

Neuroscience

Key words: anesthetized, blood-spinal barrier, conscious, edema, hemorrhage, nerve regeneration, neural regeneration, pathological mechanism, pressure measurement, rabbit, secondary spinal cord injury, telemetry

Organism: Rabbit

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2252
Chronic thromboembolic pulmonary hypertension in Austria and Japan

Stella Chausheva, Akira Naito, Aiko Ogawa, Veronika Seidl, Max-Paul Winter, Smriti Sharma, Roela Sadushi-Kolici, Ioana-Alexandra Campean, Shahroukh Taghavi, Bernhard Moser, Walter Klepetko, Keiichi Ishida, Hiromi Matsubara, Seiichiro Sakao, Irene MLang

The Journal of thoracic and cardiovascular surgery (Elsevier) Austria, Japan , 21 January 2019

Cardiology

Key words: Chronic thromboembolic pulmonary hypertension, pulmonary endarterectomy, balloon pulmonary angioplasty,

2253
Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition

Kristyna Karova, John V Wainwright, Lucia Machova-Urdzikova, Rishikaysh V Pisal, Meic Schmidt, Pavla JendelovaEmail author and Meena Jhanwar-UniyalEmail author

Journal of Neuroinflammation (Springer) Czech Republic, USA , 17 January 2019

Stem Cell Research

Key words: NF-κB, p65, Spinal cord injury, Stem cells transplantation, Inflammation, TNF-α,

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2254
The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Bojan Vilagos, Anna Orlova, Peter Majek, Katja Parapatics, Alexander Lercher, Benedikt Agerer, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, David A Rosa, Jisung Park, Patrick T Gunning, Christoph Bock, Hannah V Siddle, Stefan Kubicek, Elizabeth P Murchison, Keiryn L Bennett, Richard Moriggl, Andreas Bergthaler

Cancer Cell (Cell Press) Austria, Canada, UK, Australia , 14 January 2019

Oncology

Key words: ERBB, horizontal transmission, MHC class I, receptor tyrosine kinases, STAT3, Tasmanian devil, transmissible cancer, tumor vulnerability, systems biology xenograft

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2255
Probiotic Lactobacillus spp. Act Against Helicobacter pylori-induced Inflammation

Yi-Hsing Chen, Wan-Hua Tsai, Hui-Yu Wu, Chun-Ya Chen, Wen-Ling Yeh, Ya-Hui Chen, Hui-Ying Hsu, Wei-Wei Chen, Yu-Wen Chen, Wen-Wei Chang, Tzu-Lung Lin, Hsin-Chih Lai, Yu-Hsin Lin and Chih-Ho Lai

Journal of Clinical Medicine (MDPI) Taiwan , 14 January 2019

Microbiology

Key words: Helicobacter pylori, Lactobacillus, probiotic, inflammation

Organism: Mouse

Tissue: Stomach

Pathological State: Helicobacter pylori Infection

2256
Brain-Derived Neurotrophin and TrkB in Head and Neck Squamous Cell Carcinoma

Dudás J, Riml A, Tuertscher R, Pritz C, Steinbichler TB, Schartinger VH, Sprung S, Glueckert R, Schrott-Fischer A, Johnson Chacko L, Riechelmann H

International Journal of Molecular Sciences (MDPI) Austria , 11 January 2019

Oncology

Key words: epithelial–mesenchymal transition, vimentin, cytokeratin, p53 mutation, paraffin embedding, riboprobe

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

2257
An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun and Xiaobo Sun

Stem Cell Research & Therapy (BMC) China , 11 January 2019

Stem Cell Research

Key words: Cardiotoxicity, Sophora tonkinensis, hiPSC-CMs, Cardio-NLCS

Organism: Human

Cell Line: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

2258
Clinical significance of c-Met and phospho-c-Met (Tyr1234/1235) in ovarian cancer

L Lim, CC Wu, YT Hsu, FJ Sun, CL Chang

Taiwanese Journal of Obstetrics and Gynecology (Elsevier) Taiwan , 09 January 2019

Oncology

Key words: c-Met, phospho-c-Met, Ovarian cancer

Organism: Human

Tissue: Breast

Pathological State: Cancer

2259
High-Throughput Synapse-Resolving Two-Photon Fluorescence Microendoscopy for Deep-Brain Volumetric Imaging In Vivo

Guanghan Meng, Yajie Liang, Sarah Sarsfield, Wan-chen Jiang, Rongwen Lu, Joshua Tate Dudman, Yeka Aponte, Na Ji

eLife (eLife Sciences Publications) USA , 03 January 2019

Neuroscience

Key words: two-photon fluorescence microendoscopy, volumetric imaging, Bessel beam, hippocampus, lateral hypothalamus

Organism: Mouse

Tissue: Brain

2260
Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain

Qing Yu, Ying-Zi Liu, Yan-Bing Zhu, Yao-Yi Wang, Qian Li, Dong-Min Yin

Brain Structure and Function (Springer) China , 02 January 2019

Neuroscience

Key words: Drd2,  Knockin rats,  Olfactory bulb,  Cerebral cortex,  Hippocampus 

Organism: Mouse, Rat

Tissue: Brain

Results 2251 - 2260 of 3476

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

Keep in Touch

Be the first to hear about the latest scientific updates