Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

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Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2231 - 2240 of 3476
2231
Long noncoding RNA AOC4P regulates tumor cell proliferation and invasion by epithelial–mesenchymal transition in gastric cancer

K Zhang, C Lu, X Huang, J Cui, J Li, Y Gao, W Liang, Y Liu, Y Sun, H Liu, B Wei, L Chen

Therapeutic Advances In Gastroenterology (SAGE Journals) China , 19 February 2019

Oncology

Key words: AOC4P, long noncoding RNAs, metastasis, prognosis, stomach neoplasm

Organism: Human

Tissue: Stomach

Pathological State: Cancer

2232
B-type natriuretic peptide enhances fibrotic effects via matrix metalloproteinase-2 expression in the mouse atrium in vivo and in human atrial myofibroblasts in vitro

YT Tsai, FY Lin, CS Lin, SH Loh, CY Li, CY Lin, YW Lin, CS Tsai

Translational Research (Elsevier) Taiwan , 19 February 2019

Cardiology

Key words: B-type natriuretic peptide, atrial fibrillation, matrix metalloproteinase

Organism: Mouse

Tissue: Heart

2233
SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes

I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang

Journal of Biological Methods (Springer) Taiwan , 18 February 2019

Oncology

Key words: SOX17, Transcription regulation, Resistance, DNA repair, Concurrent chemoradiation therapy, Esophageal cancer

Organism: Human, Mouse

Tissue: Colon, Xenograft Tumor

Pathological State: Cancer

2234
Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy

X Li, Y Zhao, W Jiang, S Li, M Zhan, H Liu, C Zhang, H Liang, H Liu, L Lu, Y Wang

Biomaterials Science (Royal Society of Chemistry) China , 14 February 2019

Nanomedicine

Key words: Cascaded chemo-radiotherapy, hypoxia-activated therapy, tumor hypoxia, ultralong circulating liposome

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

2235
The Accumulation and Effects of Liposomal Doxorubicin in Tissues Treated by Radiofrequency Ablation and Irreversible Electroporation in Liver: In Vivo Experimental Study on Porcine Models

T Andrašina, J Jaroš, T Jůza, T Rohan, D Červinka, M Crha, V Válek, NS Goldberg

CardioVascular and Interventional Radiology (Springer) Czech Republic, Israel , 13 February 2019

Hepathology

Key words: Liposomal doxorubicin, Radiofrequency ablation, Irreversible electroporation

Organism: Pig

Tissue: Liver

2236
Generation of human iPSCs from fetal prostate fibroblasts HPrF

Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Radek Vrtěl, Lucie Jurečková, Volodymyr Porokh, Darja Páralová, Aleš Hampl, Karel Souček

Stem Cell Research (Elsevier) Czech Republic , 07 February 2019

Stem Cell Research

Key words: induced stem cells, iPSCs, prostate fibroblasts, HPrF

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2237
Multimodal imaging guides surgical management in a preclinical spinal implant infection model

Stephen D Zoller, Howard Y Park, Tove Olafsen, Charles Zamilpa, Zachary DC Burke, Gideon Blumstein, William L Sheppard, Christopher D Hamad, Kellyn R Hori, Jen-Chieh Tseng, Julie Czupryna, Craig McMannus, Jason T Lee, Mafalda Bispo, Francisco Romero Pastrana, Elisa JM Raineri, Jeffery F Miller, Lloyd S Miller, Jan Maarten van Dijl, Kevin P Francis, Nicholas M Bernthal

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, The Netherlands , 07 February 2019

Osteology

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spine implant infection

2238
Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

CM Lee, JH Liao, SH Chen, CH Yen, YC Lee, S Huang, S Huang, C Lin, VH Chang

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan , 07 February 2019

Pulmonology

Key words: Fluorine, Rutaecarpine, Cyclooxygenase-2, Anti-inflammatory Effects

Organism: Mouse

Tissue: Whole Organism

2239
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma

Jing Liu, Wenna Jiang, Kaili Zhao, Hongwei Wang, Tianxing Zhou, Weiwei Bai, Xiuchao Wang, Tiansuo Zhao, Chongbiao Huang, Song Gao, Tai Qin, Wenwen Yu, Bo Yang, Xin Li, Danqi Fu, Wei Tan, Shengyu Yang, He Ren, Jihui Hao

Journal of Experimental Medicine (Rockefeller University Press) China, USA , 07 February 2019

Oncology

Key words: EHF, anti-PD1 therapy, adenocarcinoma, pancreas

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

2240
EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

Anne-Sophie Ernst, Laura-Inés Böhler, Anna M Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H Marti1, Thomas Korff and Reiner Kunze

Acta Neuropathologica (Springer) Germany , 05 February 2019

Neuroscience

Key words: EphB2, Ephrin-B2, Excitotoxicity, Inflammation, Ischemic stroke, NMDA

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

Results 2231 - 2240 of 3476

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