Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2221 - 2230 of 3476
2221
γδT cells suppress liver fibrosis via strong cytolysis and enhanced NK cell-mediated cytotoxicity against hepatic stellate cells

M Liu, Y Hu, Y Yuan, Z Tian, C Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, Germany, Belgium, USA , 15 March 2019

Immunology

Key words: fibrosis, γδT cell, NKp46, cytotoxicity, γδT1, γδT17, CD137, cell crosstalk

Organism: Mouse

Tissue: Liver

Pathological State: Liver Fibrosis

2222
Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo

YH Hsu, HC Chuang, YH Lee, YF Lin, YJ Chen, TC Hsiao, MY Wu, HW Chiu

Free Radical Biology and Medicine (Elsevier) Taiwan , 14 March 2019

Toxicology

Key words: Nephrotoxicity, Autophagy, Apoptosis, Endoplasmic reticulum stress

Organism: Rat

Tissue: Kidney

2223
ErbB3 Ligand Heregulin1 Is a Major Mitogenic Factor for Uncontrolled Lung Cancer Cell Proliferation

S Ma, S Jia, Y Ren, B Cao, X Zha, J He, C Chen

Neoplasia (Elsevier) China , 02 March 2019

Oncology

Key words: ErbB3, Heregulin1, Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

2224
Sulfasalazine could modulate the CD44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer

Koichiro Ogihara, Eiji Kikuchi, Shogo Okazaki, Masayuki Hagiwara,1 Toshikazu Takeda, Kazuhiro Matsumoto, Takeo Kosaka, Shuji Mikami, Hideyuki Saya, and Mototsugu Oya

Cancer Science (NCBI) Japan , 01 March 2019

Oncology

Key words: bladder cancer, CD44v9, cisplatin, metastasis, sulfasalazine

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

2225
Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system

T Kiskova, Y Mytsko, M Schepelmann, H Helmer, R Fuchs, M Heidi, C Wadsack, I Ellinger

Placenta (Elsevier) Austria , 28 February 2019

Reproductive Medicine

Key words: Human placenta, FcRn, syncytiotrophoblast, placental-fetal endothelial cells, placental macrophages, IgG transport

Organism: Human

Tissue: Placenta

2226
High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2

S Khanal, DA Galloway

PLoS Pathogens (PLOS) USA , 28 February 2019

Virology

Key words: Immunoblotting, Oncogenes, DNA repair, Phosphorylation, Human papillomavirus, HPV-16, Cell signaling, Small interfering RNAs

Organism: Human

Pathological State: HPV Infection

Cell Line: Primary human foreskin keratinocytes (HFKs)

2227
Metabolic cross-talk between human bronchial epithelial cells and internalized Staphylococcus aureus as a driver for infection

Laura M Palma Medina, Ann-Kristin Becker, Stephan Michalik, Harita Yedavally, Elisa JM Raineri, Petra Hildebrandt, Manuela Gesell Salazar, Kristin Surmann, Henrike Pförtner, Solomon A Mekonnen, Anna Salvati, Lars Kaderali, Jan Maarten van Dijl and Uwe Völker

Molecular and Cellular Proteomics (American Society for Biochemistry and Molecular Biology) Germany, The Netherlands, , 26 February 2019

Immunology

Key words: Staphylococcus aureus, in vivo proteomics, population heterogeneity, persister, bronchial epithelial cells, Apoptosis*, Autophagy Bacteria, Energy metabolism, Host-Pathogen Interaction, Infectious disease

Organism: Human

Pathological State: Staphylococcus aureus Infection

Cell Line: Bronchial epithelial cells

2228
Ligase 3–mediated end-joining maintains genome stability of human embryonic stem cells

Aneta Kohutova, Jan Raška, Miriama Kruta, Monika Seneklova, Tomas Barta, Petr Fojtik, Tereza Jurakova, Christi A Walter, Ales Hampl, Petr Dvorak, and Vladimir Rotrekl

The FASEB Journal (FASEB) Czech Republic, USA , 26 February 2019

Stem Cell Research

Key words: base excision repair, PARP1, 53BP1, pluripotent stem cells, alternative DNA end-joining

Organism: Human

Cell Line: Human embryonic stem cells

2229
Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation

H Mir, G Kaur, N Kapur, S Bae, JW Lillard, S Singh

Scientific Reports (Nature) USA , 21 February 2019

Oncology

Key words: Cancer, Ovarian cancer

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

2230
State-of-the-Art of Profiling Immune Contexture in the Era of Multiplexed Staining and Digital Analysis to Study Paraffin Tumor Tissues

ER Parra, A Francisco-Cruz, II Wistuba

Cancers (MDPI) USA , 20 February 2019

Medical Image Analysis

Key words: immune profiling, cancer tissues, multiplexed methodologies, image analysis, spatial analysis

Results 2221 - 2230 of 3476

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