Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 1741 - 1750 of 3421
1741
Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

C Hui, H Bai, J Liu, X Lu, S Wang, Z Zhang, M Jin, Y Wang, Y Liu

Diagnostic Pathology (Springer) China , 19 February 2021

Pathology

Key words: Cervical Intraepithelial Neoplasia, CIN, Diagnostic Accuracy, E6/E7 mRNA, In Situ Hybridization

Organism: Human

Tissue: Uterus

Pathological State: Cervical lesions

1742
T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells

Abigail E Schiff, Alice H Linder, Shillah N Luhembo, Stephanie Banning, Martin J Deymier, Thomas J Diefenbach, Amy K Dickey, Athe M Tsibris, Alejandro B Balazs, Josalyn L Cho, Benjamin D Medoff, Gerhard Walzl, Robert J Wilkinson, Wendy A Burgers, Björn Corleis, Douglas S Kwon

Scientific Reports (Nature) USA, South Africa, UK, Germany , 16 February 2021

Virology

Key words: HIV Infections, Monocytes and Macrophages, Mucosal Immunology, Retrovirus, Virology, Virus–Host Interactions

Organism: Human

Tissue: Lung

Pathological State: HIV infection

1743
Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness

J Ning, Y Ye, D Bu, G Zhao, T Song, P Liu, W Yu, H Wang, H Li, X Ren, G Ying, Y Zhao, J Yu

Molecular Therapy (Elsevier) China , 15 February 2021

Oncology

Organism: Human

Tissue: Liver

Pathological State: Cancer

1744
Curcumin inhibits the growth of liver cancer by impairing myeloid‑derived suppressor cells in murine tumor tissues

S Tian, L Liao, Q Zhou, X Huang, P Zheng, Y Guo, T Deng, X Tian

Oncology Letters (Spandidos Publications) China , 12 February 2021

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1745
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4

T Guo, YH Bai, XJ Cheng, HB Han, H Du, Y Hu, SQ Jia, XF Xing, JF Ji

Cancer Communications (Wiley) China , 11 February 2021

Oncology

Key words: Gastric Cancer, Glucose Transporter 4, Glycolysis, Insulin Gene Enhancer Protein 1, Tumorigenesis

Organism: Human

Tissue: Stomach

Pathological State: Cancer

1746
Global Analysis of Lysine Acetylome Reveals the potential role of CCL18 in non‐small cell lung cancer

S Kong, L Ding, C Fan, Y Li, C Wang, K Wang, W Xu, X Shi, Q Wu, F Wang

Proteomics (Wiley) China , 11 February 2021

Proteomics

Key words: Acetylome, CCL18, Non-Small Cell Lung Cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

1747
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China , 10 February 2021

Neuroscience

Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise

Organism: Mouse

Tissue: Brain

Pathological State: Depression

1748
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms

Wolf Eilenberg, Branislav Zagrapan, Sonja Bleichert, Nahla Ibrahim, Viktoria Knöbl, Annika Brandau, Luca Martelanz, Marie-Therese Grasl, Hubert Hayden, Paimann Nawrozi, Renata Rajic, Charlotte Häusler, Alexandros Potolidis, Nawa Schirwani, Andreas Scheuba, Johannes Klopf, Peter Teubenbacher, Markus P Weigl, Patrick Kirchweger, Dietrich Beitzke, Alexander Stiglbauer-Tscholakoff, Adelheid Panzenböck, Irene Lang, Lisa-Marie Mauracher, Lena Hell, Ingrid Pabinger, Marc A Bailey, D Julian A Scott, Lars Maegdefessel, Albert Busch, Ihor Huk, Christoph Neumayer, Christine Brostjan

Translational Research (Elsevier) Austria, UK, Sweden , 09 February 2021

Cardiology

Organism: Human

Tissue: Blood Vessels

Pathological State: Abdominal aortic aneurysms

1749
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer

G Jordakieva, R Bianchini, D Reichhold, J Piehslinger, A Groschopf, SA Jensen, E Mearini, G Nocentini, R Crevenna, GJ Zlabinger, SN Karagiannis, A Klaus, E Jensen-Jarolim

OncoImmunology (Taylor & Francis) Austria, Italy, UK , 08 February 2021

Oncology

Key words: IgG4, IgE, Tumor-Associated Macrophages, M2b, Allergooncology

Organism: Human

Tissue: Colon

Pathological State: Cancer

1750
Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice

JH Liu, CH Hsieh, CY Liu, CW Chang, YJ Chen, TH Tsai

Journal of Ethnopharmacology (Elsevier) Taiwan , 07 February 2021

Pharmacology

Key words: 5-Fluorouracil (5-FU), Radix Aucklandiae, Intestinal Mucositis, Goblet Cell, Anti-Inflammatory

Organism: Mouse

Tissue: Intestine

Pathological State: Intestinal Mucositis

Results 1741 - 1750 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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