Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 1721 - 1730 of 3421
1721
Luteolin Modulates the NF-E2-Related Factor 2/Glutamate–Cysteine Ligase Pathway in Rats with Spinal Cord Injury

J Fu, W Xu, Y Zhang, H Sun, J Zhao

Journal of Medicinal Food (Mary Ann Liebert Inc.) China , 16 March 2021

Neuroscience

Key words: Luteolin, Nrf2/GCL Pathway, Oxidative Stress, Spinal Cord Injury

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1722
Machine perfused donor kidneys as a source of human renal endothelial cells

RGM Lammerts, LM Lagendijk, G Tiller, WA Dam, HL Lancaster, MR Daha, MA Seelen, BG Hepkema, RA Pol, HGD Leuvenink, G Molema, J van den Born, SP Berger, the COMBAT Consortium

American Journal of Physiology (APS Journals) The Netherlands , 15 March 2021

Nephrology

Key words: Kidney, Transplantation, Endothelial Cells, Machine Perfusion, Perfusate

Organism: Human

Pathological State: Organ Transplantation

Cell Line: MP-PRECs

1723
Genetic Drivers of Head and Neck Squamous Cell Carcinoma: Aberrant Splicing Events, Mutational Burden, HPV Infection and Future Targets

Z Dlamini, M Alaouna, S Mbatha, A Bhayat, M Mabongo, A Chatziioannou, R Hull

Genes (MDPI) South Africa, Greece , 15 March 2021

Oncology

Key words: Head and Neck Squamous Cell Carcinoma (HNSCC), Aberrant Splicing Events, Human Papillomavirus (HPV) Infection, Non-Coding RNA (ncRNA), Methylation, Mutational Burden

Pathological State: Cancer, HPV Infection

1724
A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice

HL Lee, SW Hee, CF Hsuan, W Yang, JY Huang, YL Lin, CN Hsu, JJ Hwang, SM Chen, ZZ Ding, TY Lee, YC Lin, FC Tsai, WL Su, LY Chueh, ML Hsieh, CH Chen, D Mochly-Rosen, YC Chang, LM Chuang

Antioxidants (MDPI) Taiwan, USA , 13 March 2021

Cardiology, Endocrinology

Key words: Diabetic Cardiomyopathy, 4-Hydroxy-2-Nonenal, Mitochondrial Aldehyde Dehydrogenase 2, AD-9308

Organism: Mouse

Tissue: Heart

Pathological State: Diabetes

1725
MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

European Journal of Pharmacology (Elsevier) Taiwan , 13 March 2021

Pharmacology

Key words: miR-126, Retinal Pigment Epithelium Cells, Vascular Endothelial Growth Factor, Oxygen-Induced Retinopathy, Neovascularization, Rat

Organism: Rat

Tissue: Eye

Pathological State: Retinopathy

1726
N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice

GG Liou, CC Hsieh, YJ Lee, PH Li, MS Tsai, CT Li, SH Wang

Antioxidants (MDPI) Taiwan , 12 March 2021

Hepathology

Key words: Acetaminophen Overdose, N-Acetyl Cysteine Overdose, Two Inbred Mouse Strains, Hepatic Inflammation, Systemic Inflammation, Microvesicular Steatosis

Organism: Mouse

Tissue: Liver

Pathological State: Hepatic Steatosis, Systemic Inflammation

1727
Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis

GF Rani, O Preham, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Blood Advances (ASH Publications) UK , 12 March 2021

Immunology

Key words: Blood Platelets, Infections, Leishmania Donovani, Leishmaniasis, Visceral, Mice, Thrombocytopenia, Drug Clearance, Thrombopoietin, Spleen, Liver

Organism: Mouse

Tissue: Liver

Pathological State: Leishmaniasis

1728
CHPF Regulates the Aggressive Phenotypes of Hepatocellular Carcinoma Cells via the Modulation of the Decorin and TGF-β Pathways

CH Liu, BR Wu, YJ Ho, YH Chu, WC Hsu, TJ Tseng, JP Li, WC Liao

Cancers (MDPI) Taiwan , 12 March 2021

Oncology

Key words: Hepatocellular Carcinoma, Tumor Microenvironment, Chondroitin Polymerizing Factor, Chondroitin Sulfate, Decorin

Organism: Human

Tissue: Liver

Pathological State: Cancer

1729
KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma

J Ingruber, D Savic, TB Steinbichler, S Sprung, F Fleischer, R Glueckert, G Schweigl, II Skvortsova, H Riechelmann, J Dudás

Cells (MDPI) Austria , 12 March 2021

Oncology

Key words: TissueFaxs, TWIST, ZEB, SCC-25, FaDu, UPCI-SCC090

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

1730
Dietary Modification Alters the Intrarenal Immunologic Micromilieu and Susceptibility to Ischemic Acute Kidney Injury

J Jeon, K Lee, KE Yang, JE Lee, GY Kwon, W Huh, DJ Kim, YG Kim, HR Jang

Frontiers in Immunology (Frontiers Media S.A.) South Korea , 11 March 2021

Immunology, Nephrology

Key words: Diet, High-Salt Diet, High-Fat Diet, Acute Kidney Injury, Immunologic Micromilieu, Ischemia-Reperfusion Injury

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

Results 1721 - 1730 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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