Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1441 - 1450 of 3476
1441
CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis

DW Zhang, JJ Ye, Y Sun, S Ji, JY Kang, YY Wei, GH Fei

Journal of Inflammation Research (Dovepress) China , 20 April 2022

Pulmonology

Key words: chronic obstructive pulmonary disease, emphysema, B cell, bioinformatics analysis

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

1442
Endocrine-disrupting chemicals affect sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro

A Yawer, E Sychrová, J Raška, P Babica, I Sovadinová

Food and Chemical Toxicology (Elsevier) Czech Republic , 19 April 2022

Reproductive Medicine

Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Reproductive toxicity, Sertoli cells, Testicular tumors

Organism: Human

Cell Line: Sertoli TM4 cells

1443
Computer-assisted evaluation enhances the quantification of interstitial fibrosis in renal implantation biopsies, measures differences between frozen and paraffin sections, and predicts delayed graft function

M Pavlovic, A Oszwald, Ž Kikić, MC Nackenhorst, R Kain, N Kozakowski

Journal of Nephrology (Springer) Austria, France , 19 April 2022

Medical Image Analysis

Key words: Implantation biopsy, Interstitial fibrosis, Computer-assisted evaluation, Delayed graft function

Organism: Human

Tissue: Kidney

Pathological State: Interstitial fibrosis

1444
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy

B Peng, TM Nguyen, MK Jayasinghe, C Gao, TT Pham, LT Vu, EYM Yeo, G Yap, L Wang, BC Goh, WL Tam, D Luo, MTN Le

Journal of Extracellular Vesicles (Wiley) Singapore , 16 April 2022

Oncology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

1445
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

N Mori, C Inoue, H Tamura, T Nagasaka, H Ren, S Sato, Y Mori, M Miyashita, S Mugikura, K Takase

Magnetic Resonance Imaging (Elsevier) Japan , 16 April 2022

Imaging

Key words: Breast cancer, Magnetic resonance imaging, Diffusion weighted imaging, Diffusion kurtosis imaging, Histology

Organism: Human

Tissue: Breast

Pathological State: Cancer

1446
The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease

R Takahashi, T Kanda, M Komatsu, T Itoh, H Minakuchi, H Urai, T Kuroita, S Shigaki, T Tsukamoto, N Higuchi, M Ikeda, R Yamanaka, N Yoshimura, T Ono, H Yukioka, K Hasegawa, H Tokuyama, S Wakino, H Itoh

Scientific Reports (Nature) Japan , 16 April 2022

Nephrology

Key words: Medical research, Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

1447
Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway

Y Sun, Y Qian, C Chen, H Wang, X Zhou, W Zhai, L Qiu, X Zhou, H Ning, Y Zhao, C Shi, L Han, Y Qi, Y Wu, Y Gao

Journal of Experimental & Clinical Cancer Research (BMC) China , 15 April 2022

Oncology

Key words: Esophageal squamous cell carcinoma, IL-32, Extracellular vesicle, M2 macrophage polarization, Metastasis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

1448
Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice

YH Mao, Y Xu, F Song, ZM Wang, YH Li, M Zhao, F He, Z Tian, Y Yang

Carbohydrate Polymers (Elsevier) China , 14 April 2022

Gastroenterology

Key words: Polysaccharides, Molecular weight, Prebiotic fiber, Protection, Dysbiosis

Organism: Mouse

Tissue: Colon

Pathological State: Dysbiosis

1449
AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

E Gonçalves-Alves, M Garcia, CJ Rodríguez-Hernández, S Gómez-González, R Ecker, M Suñol, O Muñoz-Aznar, AM Carcaboso, J Mora, C Lavarino, S Mateo-Lozano

International Journal of Molecular Sciences (MDPI) Spain, Austria , 13 April 2022

Oncology

Key words: neuroblastoma, calcium-sensing receptor, calcimimetic, cinacalcet, AC-265347, biased signaling, differentiation, cancer-testis antigens

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1450
A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects

M Ng, S Chen, WS Ong, A Balachander, A Seet, J Yeong, N Sutiman, TKH Lim, B Lee, YA Guo, WF Leong, SS Lee, J Lam, SP Choo, AJ Skanderup, SK Biswas, D Tai, B Chowbay

International Journal of Cancer (Wiley) Singapore , 12 April 2022

Oncology

Key words: PDAC, OXIRI, metronomic oxaliplatin, chronomodulated capecitabine, UGT1A1, irinotecan

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

Results 1441 - 1450 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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