Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1431 - 1440 of 3476
1431
Prognostic values of B7-H3, B7-H4, and HHLA2 expression in human pancreatic cancer tissues based on mIHC and spatial distribution analysis

Y Zhu, J Chen, Y Liu, X Zheng, J Feng, X Chen, T Jiang, Y Li, L Chen

Pathology-Research and Practice (Elsevier) China , 29 April 2022

Oncology

Key words: B7-H3, B7-H4, HHLA2, Multi-color immunohistochemistry, Prognosis, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1432
PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

X Tan, J Bednarsch, M Rosin, S Appinger, D Liu, G Wiltberger, J Garcia Vallejo, SA Lang, Z Czigany, S Boroojerdi, NT Gaisa, P Boor, RD Bülow, J De Vos-Geelen, L Valkenburg-van Iersel, MC Clahsen-van Groningen, EJM de Jong, BG Koerkamp, M Doukas, FG Rocha, T Luedde, U Klinge, S Sivakumar, UP Neumann, LR Heij

Cancers (MDPI) Germany, The Netherlands, USA, UK , 27 April 2022

Oncology

Key words: cholangiocarcinoma, liver cancer, tumor microenvironment, nerve fiber density, immune checkpoint, immune cells

Organism: Human

Tissue: Bile duct

Pathological State: Cancer

1433
Corallodiscus flabellata BL Burtt extract and isonuomioside A ameliorate Aβ25− 35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway

M Zeng, A Feng, M Li, M Liu, P Guo, Y Zhang, Q Zhang, B Zhang, B Cao, J Jia, R Wang, J Lyu, X Zheng

Phytomedicine (Elsevier) China , 27 April 2022

Toxicology

Key words: Isonuomioside A, Corallodiscus flabellata B. L. Burtt extract, NMDAR2B, Apoptosis, Oxidative stress, Autophagy

Organism: Mouse

Tissue: Brain

1434
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target

BC Moraes, HV Ribeiro-Filho, AP Roldão, EF Toniolo, GPB Carretero, GG Sgro, FAH Batista, DE Berardi, VRS Oliveira, R Tomasin, FM Vieceli, DT Pramio, AB Cardoso, ACM Figueira, SC Farah, LA Devi, CS Dale, PSL de Oliveira, D Schechtman

Science Signaling (Science) Brazil, USA , 26 April 2022

Pharmacology

1435
Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site

Y Jing, F Bai, L Wang, D Yang, Y Yan, Q Wang, Y Zhu, Y Yu, Z Chen

Microbiology Spectrum (ASM Journals) China , 25 April 2022

Microbiology, Neuroscience

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

1436
Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy

CS Khoi, CQ Xiao, KY Hung, TY Lin, CK Chiang

Biomedicines (MDPI) Taiwan , 25 April 2022

Cell Biology

Key words: palmitic acid, OSGIN1, unfolded protein response, XBP1s, autophagy, eNOS, endothelial cells

Organism: Human

Tissue: Blood Vessels

Pathological State: Atherosclerosis

1437
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

X Lu, K Fong, G Gritsina, F Wang, SC Baca, LT Brea, JE Berchuck, S Spisak, J Ross, C Morrissey, E Corey, NS Chandel, WJ Catalona, X Yang, ML Freedman, JC Zhao, J Yu

Nature Genetics (Nature) USA , 25 April 2022

Oncology

Key words: Epigenomics, Prostate cancer, Targeted therapies

Organism: Human

Tissue: Prostate

Pathological State: Cancer

1438
HLA class I downregulation in progressing metastases of melanoma patients treated with ipilimumab

A Ladányi, B Hegyi, T Balatoni, G Liszkay, R Rohregger, C Waldnig, J Dudás, S Ferrone

Pathology and Oncology Research (Elsevier) Hungary, Austria, USA , 22 April 2022

Oncology

Key words: immunotherapy, melanoma, ipilimumab, HLA class I expression, longitudinal study

Organism: Human

Tissue: Skin

Pathological State: Cancer

1439
Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes

L Huang, Z Chen, R Chen, L Lin, L Ren, M Zhang, L Liu

Redox Biology (Elsevier) China , 21 April 2022

Endocrinology

Key words: Hypoglycemia, Diabetes, Lipid metabolism, β-adrenoceptor, Mitochondrial reactive oxygen species

Organism: Mouse

Tissue: Heart

1440
CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by

C Liu, X Cheng, J Xing, J Li, Z Li, D Jian, Y Wang, S Wang, R Li, W Zhang, D Shao, X Ma, X Chen, J Shen, C Shi, Z Gao, W Wang, T Fan, L Liu, H Tang

International Journal of Biological Sciences (Ivyspring International Publisher) China , 20 April 2022

Cardiology, Oncology

Key words: CIRBP, Cardioprotection, OGFR, Chemotherapy-induced cardiotoxicity, Cardiomyocyte apoptosis

Organism: Mouse

Tissue: Heart

Results 1431 - 1440 of 3476

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