Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1411 - 1420 of 3476
1411
Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

M Schepelmann, M Ranieri, I Lopez-Fernandez, TS Webberley, SC Brennan, PL Yarova, J Graca, UK Hanif, C Müller, T Manhardt, M Salzmann, H Quasnichka, SA Price, DT Ward, T Gilbert, VV Matchkov, RA Fenton, A Herberger, J Hwong, C Santa Maria, CL Tu, E Kallay, G Valenti, W Chang, D Riccardi

Journal of The American Society of Nephrology (ASN) UK, Austria, Italy, Australia, USA, France, Denmark , 17 May 2022

Endocrinology

Key words: calcium-sensing receptor, mineral metabolism, vascular calcification, hypercalcemia, transgenic mouse, vascular smooth muscle

Organism: Mouse

Tissue: Kidney

1412
Downregulated ADAMTS1 Incorporating A2M Contributes to Tumorigenesis and Alters Tumor Immune Microenvironment in Lung Adenocarcinoma

HC Lee, CY Chang, YC Huang, KL Wu, HH Chiang, YY Chang, LX Liu, JY Hung, YL Hsu, YY Wu, YM Tsai

Biology (MDPI) Taiwan , 16 May 2022

Oncology

Key words: A2M, ADAMTS1, EMT, immunity, LUAD, metastasis

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1413
Organ‐specific immune response in lethal SARS‐CoV‐2 infection by deep spatial phenotyping

A Balachander, B Lee, SK Biswas, DC Lye, RTP Lin, YS Leo, P Chui, LFP Ng, L Renia

Clinical & Translational Immunology (Wiley) Singapore , 15 May 2022

Virology, Immunology

Key words: COVID-19, immunopathology, in situ spatial multiplexing, SARS-CoV-2 infection

Organism: Human

Tissue: Lung, Intestine, Heart

Pathological State: COVID-19

1414
Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma

C Dmello, A Sonabend, VA Arrieta, DY Zhang, D Kanojia, L Chen, A Gould, J Zhang, SJ Kang, J Winter, C Horbinski, C Amidel, B Győrffy, A Cordero, C Lee-Chang, B Castro, P Hsu, AU Ahmend, MS Lesniak, R Stupp, AM Sonabend

Clinical Cancer Research (AACR Publications) USA, Germany, Hungary , 12 May 2022

Oncology

Key words: Paclitaxel, biomarker, glioblastoma, breast cancer, SSR3

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

1415
Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model

SM Schmitz, MJ Helmedag, KM Kossel, RM Eickhoff, D Heise, A Kroh, M Mechelinck, T Gries, S Jockenhoevel, UP Neumann, A Lambertz

International Journal of Molecular Sciences (MDPI) Germany, The Netherlands , 11 May 2022

Tissue Engineering

Key words: biomaterial, TPU, surgical thread, suture material, elastic suture, gastrointestinal anastomosis

1416
Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease

R Munemura, T Maehara, Y Murakami, R Koga, R Aoyagi, N Kaneko, A Doi, CA Perugino, E Della-Torre, T Saeki, Y Sato, H Yamamoto, T Kiyoshima, JH Stone, S Pillai, S Nakamura

Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, Italy , 11 May 2022

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, IgG4-RD, IgG4, IgE, Tfh cell, B cell, interleukin-10, class switch, fibrosis

Organism: Human

Tissue: Salivary Gland

Pathological State: IgG4-related disease, Kimura disease

1417
In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells

E Sychrová, A Yawer, P Labohá, A Basu, A Dydowiczová, I Virmani, P Babica, I Sovadinová

Environmental Toxicology and Pharmacology (Elsevier) Czech Republic , 10 May 2022

Reproductive Medicine, Toxicology

Key words: 3D in vitro models, Endocrine-disrupting chemicals, Leydig cells, Lipotoxicity, Reproductive toxicity, Spheroids

Tissue: Spheroid

Cell Line: Leydig TM3 cells

1418
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study

M Schepelmann, N Kupper, V Gushchina, I Mesteri, T Manhardt, S Moritsch, S Müller, K Piatek, M Salzman, A Vlasaty, R Eferl, E Kallay

International Journal of Molecular Sciences (MDPI) Austria, Germany , 09 May 2022

Oncology, Gastroenterology

Key words: aged mice, colitis associated colorectal cancer, AOM, DSS, mouse strain differences, pilot study

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

1419
Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy

SJ Huang, TH Wang, YH Chou, HMD Wang, TC Hsu, JL Yow, BS Tzang, WH Chiang

International Journal of Biological Macromolecules (Elsevier) Taiwan , 05 May 2022

Nanomedicine, Oncology

Key words: Acidity-responsive nanovehicles, PEGylated chitosan, cancer chemotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1420
Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response

Q Ke, L Gong, X Zhu, R Qi, M Zou, B Chen, W Liu, S Huang, Y Liu, DWC Li

Cells (MDPI) China , 05 May 2022

Key words: multinucleation, retinal pigment epithelium, reactive oxygen species, photoreceptor, DNA damage, p53

Organism: Mouse

Tissue: Eye

Results 1411 - 1420 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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