Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 1331 - 1340 of 3421
1331
Evaluation of Topical and Subconjunctival Injection of Hyaluronic Acid-Coated Nanoparticles for Drug Delivery to Posterior Eye

CH Tsai, LN Hoang, CC Lin, LC Pan, CL Wu, IC Lin, PY Wang, CL Tseng

Pharmaceutics (MDPI) Taiwan, China , 13 June 2022

Nanomedicine

Key words: posterior eye, hyaluronic acid, surface charges, nanoparticles, drug delivery, eyedrops, subconjunctival injection, retina

Organism: Mouse

Tissue: Eye

1332
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro

C Hromada, J Hartmann, J Oesterreicher, A Stoiber, A Daerr, B Schädl, E Priglinger, AH Teuschl-Woller, W Holnthoner, J Heinzel, D Hercher

Biomolecules (MDPI) Austria, Germany , 12 June 2022

Neuroscience

Key words: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells

Cell Line: Fibrin hydrogels containing Schwann cell, lymphatic endothelial cells and adipose-derived stem cells

1333
Accumulation of Cytotoxic Skin Resident Memory T Cells and Increased Expression of IL-15 in Lesional Skin of Polymorphic Light Eruption

VK Patra, J Strobl, D Atzmüller, B Reininger, L Kleissl, A Gruber-Wackernagel, JF Nicolas, G Stary, M Vocanson, P Wolf

Frontiers in Medicine (Frontiers Media S.A.) France, Austria , 10 June 2022

Dermatology, Allergy Research

Key words: sun allergy, polymorphic light eruption, disease recurrence, inflammation, disease memory, resident memory T cell (TrM)

Organism: Human

Tissue: Skin

Pathological State: Polymorphic light eruption (PLE)

1334
A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells

F Liang, LM Nilsson, F Byvald, A Rezapour, H Taflin, JA Nilsson, U Yrlid

Cancers (MDPI) Sweden, Australia , 10 June 2022

Oncology

Key words: colorectal liver metastases, tumor-infiltrating lymphocytes, tissue-resident memory T cells, patient-derived xenograft model, MEK inhibition

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1335
Long‐term outcomes of arterial ischemia or venous occlusion on vascularized groin lymph nodes in a rat model

CY Yang, IE Tinhofer, MH Cheng

Journal of Surgical Oncology (Wiley) Taiwan, Austria , 09 June 2022

Angiology

Key words: arterial ischemia, lymphedema, vascularized lymph node transfer, venous congestion

Organism: Rat

Tissue: Lymphoid Tissue

Pathological State: Arterial ischemia

1336
Proteomic analysis of hepatic fibrosis induced by a high starch diet in largemouth bass (Micropterus salmoides)

X Wu, X Gu, M Xue, C Ge, X Liang

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics (Elsevier) China , 08 June 2022

Zoology, Endocrinology

Key words: High starch diet, Hepatic fibrosis, Proteomics, PRM, Micropterus salmoides

Organism: Fish

Tissue: Liver

Pathological State: Hepatic fibrosis

1337
Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5

P Qiu, Y Jie, C Ma, H Chen, Y Qin, K Tu, L Wang, Z Zhang

Cell Death Discovery (Nature) China , 07 June 2022

Oncology

Key words: Cancer, Oncogenesis

Organism: Human

Tissue: Uterus

Pathological State: Cancer

1338
Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses

X Cai, Z Zhou, J Zhu, X Liu, G Ouyang, J Wang, Z Li, X Li, H Zha, C Zhu, F Rong, J Tang, Q Liao, X Chen, W Xiao

Cell Reports (Cell Press) China , 07 June 2022

Immunology

Key words: OTUD3, RIG-I, MDA5, cGAS, deubiquitination, innate immunity

Organism: Mouse

Tissue: Lung

Pathological State: Virus Infection

1339
Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD

TJ Wu, SH Wang, ESW Chen, HH Tsai, YC Chang, YH Tseng, J Yu

Cellular and Molecular Life Sciences (Springer) Taiwan , 07 June 2022

Pulmonology

Key words: COPD, Fut8, Core-fucosylation, SPARC, Matricellular protein, Collagen

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

1340
Diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury

CB Liu, DG Yang, J Li, C Qin, X Zhang, J Liu, DP Li, JJ Li

Neural Regeneration Research (Publishing House of Neural Regeneration Research) China , 06 June 2022

Neuroscience

Key words: spinal cord injury, diffusion tensor imaging, canines, pathophysiology, cerebrospinal structures, corticospinal tract, magnetic resonance imaging, anisotropic fraction, apparent dispersion coefficient

Organism: Dog

Tissue: Brain

Pathological State: Spinal cord injury

Results 1331 - 1340 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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