Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1321 - 1330 of 3476
1321
P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma

V Arnaud-Sampaio, C Bento, T Glaser, E Adinolfi, H Ulrich, C Lameu

Frontiers in Oncology (Frontiers Media S.A.) Brazil, Italy , 25 August 2022

Pharmacology, Oncology

Key words: P2X7 receptor isoforms, chemoresistance, childhood cancer, cancer, drug efflux, cancer stem cells, autophagy, epithelial-mesenchymal transition

Cell Line: ACN human neuroblastoma cells

1322
KI Essence extract (a spleen-tonifying formula) promotes neurite outgrowth, alleviates oxidative stress and hypomyelination, and modulates microbiome in maternal immune activation offspring

GA Lee, HW Zhao, YW Chang, CJ Lee, YSH Yang, YC Wu, WL Lin, YR Liu, DS Ning, SH Tseng

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan , 25 August 2022

Pharmacology

Key words: mushroom, maternal immune activation, myelination, microbiota, oxidative stress, spleen-tonifying formula

Organism: Rat

Tissue: Brain

1323
Thymidine and 2′-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35 induced brain injury

M Liu, M Zeng, S Wang, B Cao, P Guo, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, J Li, X Zheng, W Feng

Archives of Biochemistry and Biophysics (Elsevier) China , 24 August 2022

Neuroscience

Key words: Thymidine, 2′-deoxyuridine, Glycolytic metabolism, Microglia activation, Oxidative stress, Brain injury

Organism: Mouse

Tissue: Brain

Pathological State: Aβ25-35-induced brain injury

1324
Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC.

K Li, Y Gong, D Qiu, H Tang, J Zhang, Z Yuan, Y Huang, Y Qin, L Ye, Y Yang

Journal for ImmunoTherapy of Cancer (BMJ Journals) China , 24 August 2022

Oncology

Key words: Immunity, Innate, Immunotherapy, Liver Neoplasms, Lymphocytes, Tumor-Infiltrating, Tumor Microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1325
The medial wall and medial compartment of the cavernous sinus: an anatomic study using plastinated histological sections

K Shi, Z Li, X Wu, C Ma, X Zhu, L Xu, Z Sun, S Xu, L Liang

Neurosurgical Review (Springer) China , 19 August 2022

Neuroscience

Key words: Cavernous sinus, Medial wall, Dura mater, Plastination

Organism: Human

Tissue: Bone

1326
Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae

ZY Chen, YC Yang, BJ Wang, FY Cheng, YL Lee, YH Lee, YJ Wang

Ecotoxicology and Environmental Safety (Elsevier) Taiwan , 17 August 2022

Toxicology, Zoology

Key words: Zinc oxide nanoparticles (ZnONPs, Danio rerio, Surface modification, Liver toxicity, Developmental changes, Autophagy

Organism: Fish

Tissue: Embryo

1327
TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma

S Hu, H Lu, W Xie, D Wang, Z Shan, X Xing, XM Wang, J Fang, W Dong, W Dai, J Guo, Y Zhang, S Wen, XY Guo, Q Chen, F Bai, Z Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) China , 16 August 2022

Oncology, Immunology

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

1328
Papillary Renal Neoplasm with Reverse Polarity—a Comparative Study with CCPRCC, OPRCC, and PRCC1

T Wang, X Ding, X Huang, J Ye, H Li, S Cao, Y Gao, X Ma, Q Huang, B Wang

Human Pathology (Elsevier) China , 14 August 2022

Nephrology

Key words: Papillary renal neoplasm with reverse polarity, Papillary renal cell carcinoma type 1, Clear cell papillary renal cell carcinoma, Oncocytic papillary renal cell carcinoma, Whole exon sequencing, KRAS

Organism: Human

Tissue: Kidney

Pathological State: Cancer

1329
Comparison of H7N9 and H9N2 influenza infections in mouse model unravels the importance of early innate immune response in host protection

C Zhu, M Zhang, Y He, Y Yang, L Zhang, S Zuan, L Jiang, J Xu, X Zhang

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China , 12 August 2022

Virology, Immunology

Key words: H7N9, H9N2, pathological characteristics, C57BL/6 mice, lung

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

1330
Stereotaxic atlas of the infant rat brain at postnatal days 7–13

YN Chen, X Zheng, HL Chen, JX Gao, XX Li, JF Xie, YP Xie, K Spruyt, YF Shao, YP Hou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, France , 12 August 2022

Neuroscience, Developmental Biology

Key words: infant rat, brain, atlas, stereotaxic coordinates, neural development

Organism: Rat

Tissue: Brain

Results 1321 - 1330 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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