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Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1191 - 1200 of 3476
1191
Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis

HY Li, SY Huang, DD Zhou, RG Xiong, M Luo, A Saimaiti, MK Han, RY Gan, HL Zhu, HB Li

Journal of Advanced Research (Elsevier) China , 11 January 2023

Hepathology

Key words: non-alcoholic fatty liver disease, anti-obesity, theabrownin, serotonin, gut microbiota

Organism: Mouse

Tissue: Liver

1192
Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

D Liu, C Liang, B Huang, X Zhuang, W Cui, L Yang, Y Yang, Y Zhang, X Fu, X Zhang, L Du, W Gu, X Wang, C Yin, R Chai, B Chu

Advanced Science (Wiley) China, USA , 10 January 2023

Oncology

Key words: 3-HA, 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), 5-HT, ferroptosis, kynureninase (KYNU, monoamine oxidase A (MAOA), tryptophan

Organism: Human

Tissue: Liver, Kidney

Pathological State: Cancer

1193
Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

R Chi, C Chai, G Liu, H Cao, B Yang

Human Cell (Springer) China , 10 January 2023

Cardiology

Key words: OSAS, CIH, Autophagy, BNIP3, Apoptosis, Cardiac hypertrophy

Organism: Rat

Tissue: Heart

Pathological State: Contractile dysfunction

1194
Immune dysregulation in immunoglobulin G4–related disease

T Maehara, R Koga, S Nakamura

Japanese Dental Science Review (Elsevier) Japan , 09 January 2023

Immunology

Key words: Autoimmune, Anti-inflammatory, Single-cell RNA sequencing, IgG4-related disease, Cytotoxic T cells, Salivary gland

1195
Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive 18F-FDG PET/CT and Serum 1H-NMR Analysis: An Orthotopic Murine Model Study

YH Chung, TH Hung, CF Yu, CK Tsai, CC Weng, F Jhang, FH Chen, G Lin

Metabolites (MDPI) Taiwan , 09 January 2023

Oncology

Key words: lung cancer, 18F-FDG, 1H-NMR, animal study, metastasis

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

1196
Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance

F Du, G Yin, L Han, X Liu, D Dong, K Duan, J Huo, Y Sun, L Cheng

Neuroscience Bulletin (Springer) China , 09 January 2023

Neuroscience

Key words: μ-opioid receptor, Morphine, Mechanical allodynia, Punctate allodynia, Dynamic allodynia, OIH, Tolerance, Aβ-fiber

Organism: Mouse

Tissue: Brain, Spinal Cord

Pathological State: Mechanical Allodynia

1197
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts

YC Huang, MF Hou, YM Tsai, YC Pan, PH Tsai, YS Lin, CY Chang, EM Tsai, YL Hsu

Cellular Oncology (Springer) Taiwan , 06 January 2023

Oncology

Key words: Acetyl-CoA carboxylase α, Breast cancer, Metabolism reprogramming, Pre-metastatic niche, Senescence

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1198
Role of iodine density value on dual-energy CT for detection of high tumor cell proportion region in lung cancer during CT-guided transthoracic biopsy

Y Ma, S Li, G Huang, X Huang, Q Zhou, W Wang, J Wang, F Zhao, Z Li, X Chen, B Zhu, J Zhou

European Journal of Radiology (Elsevier) China , 06 January 2023

Oncology, Radiotherapy

Key words: Dual-layer spectral detector computed tomography, Iodine density, Transthoracic lung biopsy, High tumor cell proportion region

Organism: Human

Tissue: Lung

Pathological State: Cancer

1199
Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis

BY Ahn, Y Jeong, S Kim, Y Zhang, SW Kim, YE Leem, JS Kang

Experimental & Molecular Medicine (Nature) South Korea , 06 January 2023

Cell Biology

Key words: Calcification, Stress signalling

Organism: Mouse

Tissue: Blood Vessels

1200
PLVAP as an Early Marker of Glomerular Endothelial Damage in Mice with Diabetic Kidney Disease

EE Wolf, A Steglich, F Kessel, H Kröger, J Sradnick, S Reichelt-Wurm, K Eidenschink, MC Banas, E Wolf, R Wanke, F Gembardt, VT Todorov

International Journal of Molecular Sciences (MDPI) Germany , 06 January 2023

Nephrology

Key words: diabetic kidney disease, endothelial damage, PLVAP, diabetic models, glomerular hypertrophy

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetic Kidney Disease

Results 1191 - 1200 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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