Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

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Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 1071 - 1080 of 3421
1071
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection

VN Hariharan, M Shin, CW Chang, D O'Reilly, A Biscans, K Yamada, Z Guo, M Somasundaran, Q Tang, K Monopoli, PM Krishnamurthy, G Devi, N McHugh, DA Cooper, D Echeverria, J Cruz, IL Chan, P Liu, SY Lim, J McConnell, S Prakash Singh, S Hildebrand, J Sousa, SM Davis, Z Kennedy, C Ferguson, BMD Godinho, Y Thillier, J Caiazzi, S Ly, M Muhuri, K Kelly, F Humphries, A Cousineau, KM Parsi, Q Li, Y Wang, R Maehr, G Gao, D Korkin, WM McDougall, RW Finberg, KA Fitzgerald, JP Wang, JK Watts, A Khvorova

PNAS (Proceedings of the National Academy of Sciences of the United States of America) USA , 09 March 2023

Virology, Immunology

Key words: SARS-COV-2, antisense oligos, small interfering RNAs, mouse model, lung

Organism: Mouse

Tissue: Lung

Pathological State: Covid-19

1072
Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass (Micropterus salmoides) fed a cottonseed protein concentrate-based diet

X Xie, X Liang, H Wang, Q Zhu, J Wang, Y Chang, E Leclercq, M Xue, J Wang

Animal Nutrition (Elsevier) China, France , 07 March 2023

Zoology

Key words: Cottonseed protein concentrate, Multi-yeast strain fractions, Micropterus salmoides, Liver health, Bile acid metabolism, Gut microbiota

Organism: Fish

Tissue: Liver, Intestine

1073
In Situ Formation of Injectable Gelatin Methacryloyl (GelMA) Hydrogels for Effective Intraocular Delivery of Triamcinolone Acetonide

C Shen, X Zhao, Z Ren, B Yang, X Wang, A Hu, J Hu

International Journal of Molecular Sciences (MDPI) China , 04 March 2023

Pharmacology

Key words: gelatin methacryloyl, triamcinolone acetonide, retina hydrogel system, hydrogel drug release, intraocular drug delivery, injectable gel

Organism: Rabbit

Tissue: Eye

1074
The protective effect of cannabinoids against colorectal cancer cachexia through modulation of inflammation and immune responses

SK Ng, DJ Chung, LC Chang, CK Luo, SH Jwo, YH Lee, JS Lin, CH Wang, TT Wei

Biomedicine & Pharmacotherapy (Elsevier) Taiwan , 03 March 2023

Immunology, Oncology

Key words: Colorectal cancer cachexia, Cytokines, Cannabinoids, CD8+ T cell, Cannabinoid receptor 2

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

1075
Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration

LW Lin, SW Wang, WC Huang, TK Huynh, CY Lai, CY Ko, YC Fong, JJ Lee, SF Yang, CH Tang

Cells (MDPI) Taiwan , 03 March 2023

Aging

Key words: melatonin, endothelial progenitor cells, vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), angiogenesis, neovascular age-related macular degeneration

Cell Line: Endothelial progenitor cells

1076
miR-194 upregulates CYP7A1 expression via β-catenin signaling and aggravates cholestatic liver diseases

PC Chen, CP Hsu, SY Wang, TY Wu, YJ Lin, YT Chen, SH Hsu

The American Journal of Pathology (Elsevier) Taiwan , 02 March 2023

Hepathology

Organism: Mouse

Tissue: Liver

1077
Androgen therapy does not prevent bone loss and arterial calcifications in male rats with CKD

K David, V Dubois, A Verhulst, V Sommers, D Schollaert, L Deboel, K Moermans, G Carmeliet, P D'Haese, D Vanderschueren, F Claessens, P Evenepoel, B Decallonne

Journal of Endocrinology (Society for Endocrinology) Belgium , 01 March 2023

Endocrinology

Key words: androgen replacement therapy, chronic kidney disease, hypogonadism, bone loss, arterial calcification

Organism: Rat

Tissue: Blood Vessels

Pathological State: Kidney disease

1078
Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells

MQ Yan, Y Wang, Z Wang, XH Liu, YM Yang, XY Duan, H Sun, XM Liu

Journal of the Endocrine Society (Oxford Academic) China , 28 February 2023

Oncology

Key words: mitochondrial fusion, testosterone, granulosa cells, steroidogenic acute regulatory protein, sex hormones, polycystic ovary syndrome

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

1079
Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo

P Strasser, B Montsch, S Weiss, H Sami, C Kugler, S Hager, H Schueffl, R Mader, O Brüggemann, CR Kowol, M Ogris, P Heffeter, I Teasdale

Small (Wiley) Austria , 26 February 2023

Nanomedicine

Key words: biodistribution, bottlebrush polymers, nanomedicine, pharmacokinetics, polyglutamate, polymer therapeutics, polyphosphazenes

Organism: Mouse

Tissue: Bone, Kidney, Xenograft Tumor

Pathological State: Cancer

1080
Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy

YT Hsu, LH Chen, YH Liu, SK Chu, TY Chen, KJ Tsai, MR Shen, W Liu

Small Methods (Wiley) Taiwan, USA , 26 February 2023

Neuroscience

Key words: bone marrow niche, chemotherapy-induced nerve damage, electrical neuromodulation, hematopoiesis

Organism: Rat

Tissue: Bone

Results 1071 - 1080 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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