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Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 1011 - 1020 of 3476
1011
AlF-NOTA-FAPI-04 PET/CT can predict treatment response and survival in patients receiving chemotherapy for inoperable pancreatic ductal adenocarcinoma

Z Zhu, K Cheng, Z Yun, X Zhang, X Hu, J Liu, F Wang, Z Fu, J Yue

European Journal of Nuclear Medicine and Molecular Imaging (Springer) China , 17 June 2023

Oncology

Key words: Fibroblast activation protein, Pancreatic adenocarcinoma, Metabolic tumor volume, Total lesion FAP expression

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1012
TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway

W Wu, J Xu, D Gao, Z Xie, W Chen, W Li, Q Yuan, L Duan, Y Zhang, X Yang, Y Chen, Z Dong, K Liu, Y Jiang

Cell Death & Disease (Nature) China , 16 June 2023

Oncology

Key words: Immunochemistry, Oncogenes

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

1013
Probiotic lactic acid bacteria alleviate pediatric IBD and remodel gut microbiota by modulating macrophage polarization and suppressing epithelial apoptosis

H Hua, C Pan, X Chen, M Jing, J Xie, Y Gao, J Huang, X Chen, Y Gao, C Xu, P Li

Frontiers in Microbiology (Frontiers Media S.A.) China , 15 June 2023

Microbiology

Key words: pediatric IBD, macrophage polarization, intestinal epithelium apoptosis, Akkermansia muciniphila, Pediococcus pentosaceus CECT8330

Organism: Mouse

Tissue: Colon

Pathological State: Inflammatory bowel disease

1014
Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration

W Xu, X Liu, W Han, K Wu, M Zhao, T Mei, B Shang, J Wu, J Luo, Y Lai, B Yang, Y Zhuo, L Lu, Y Liu, XL Tian, L Zhao

Cell Communication and Signaling (BMC) China , 14 June 2023

Ophthalmology

Key words: HTRA1, Hypoxia, HIF1α, Retinal pigment epithelium, Cell senescence, Age-related macular degeneration

Organism: Mouse

Tissue: Eye

Pathological State: Retinal degeneration

1015
SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy

JBM Kamarudin, B Sun, ASC Foo, XY Lim, H Judd, X Tan, XH Tan, RB Razar, M Liu, J Zhong, JJ Chua, CWQ Ng, JCH Goh, TZ Tan, BH Parikh, X Su, AP Kumar, WY Ong, N Yamaguchi, SY Set, GW Yip, Y Zhang, DBL The

ACS Nano (ACS Publications) Singapore, Japan , 12 June 2023

Oncology, Pharmacology

Key words: Photodynamic therapy near-infrared upconversion nanoparticle implant breast cancer 5-aminolevulinic acid

Organism: Mouse

1016
Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy

M Yang, Z Wang, J Xie, M Reyad-ul-Ferdous, S Li, Y Song

Chronic Diseases and Translational Medicine (Wiley) China , 11 June 2023

Pharmacology, Hepathology

Key words: apoptosis, autophagy, cyclophilin D, ischemia/reperfusion, necrosis, reactive oxygen species

Organism: Mouse

Tissue: Liver

Pathological State: liver ischemia/reperfusion injury

1017
Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury

L Ferrie, P Premnath, A Olsen, L Larijani, BA Besler, DE Rancourt, NA Duncan, TM Underhill, RJ Krawetz

Scientific Reports (Nature) Canada , 09 June 2023

Osteology

Key words: Bone, Musculoskeletal system, Osteoporosis, Pluripotent stem cells

Organism: Mouse

Tissue: Bone

Pathological State: Bone injury

1018
RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer

S Zhang, J Wang, W Hu, L He, Q Tang, J Li, M Jie, X Li, C Liu, Q Ouyang, S Yang, C Hu

JCI insight (The American Society for Clinical Investigation) China , 08 June 2023

Gastroenterology, Oncology

Key words: Cancer gene therapy, Gastric cancer, Oncogenes

Organism: Human

Tissue: Stomach

Pathological State: Cancer

1019
Topical ozone accelerates diabetic wound healing by promoting re-epithelialization via activation of IGF1R-EGFR signaling

JY Lu, XQ Wang, ZB Fu, LH Gao, H Mannam, YP Xiang, YY Joo, JR Zeng, D Wang, AS Paller

Journal of Investigative Dermatology (Elsevier) China, USA , 08 June 2023

Dermatology

1020
Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

X Wu, EAB Azizan, E Goodchild, S Garg, M Hagiyama, CP Cabrera, FL Fernandes-Rosa, S Boulkroun, JL Kuan, Z Tiang, A David, M Murakami, CA Mein, E Wozniak, W Zhao, A Marker, F Buss, RS Saleeb, J Salsbury, Y Tezuka, F Satoh, K Oki, AM Udager, DL Cohen, H Wachtel, PJ King, WM Drake, M Gurnell, J Ceral, A Ryska, M Mustangin, YP Wong, GC Tan, M Solar, M Reincke, WE Rainey, RS Foo, Y Takaoka, SA Murray, MC Zennaro, F Beuschlein, A Ito, MJ Brown

Nature Genetics (Nature) UK, Malaysia, Japan, France, Singapore, Germany, USA, Czech Republic, Switzerland , 08 June 2023

Cardiology

Key words: Genetics research, Translational research

Organism: Human

Tissue: Stomach

Pathological State: Cancer

Results 1011 - 1020 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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