Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 991 - 1000 of 3421
991
Cytolytic CD8+ T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes

DR Collins, J Hitschfel, JM Urbach, GH Mylvaganam, NL Ly, U Arshad, ZJ Racenet, AG Yanez, TJ Diefenbach, BD Walker

Science Immunology (Science) USA, Germany , 19 May 2023

Immunology, Virology

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

992
Following nanoparticle uptake by cells using high-throughput microscopy and the deep-learning based cell identification algorithm Cellpose

B Yang, CJ Richards, TB Gandek, I de Boer, IA Zuazo, E Niemeijer, C Aberg

Frontiers in Nanotechnology (Frontiers Media S.A.) , 18 May 2023

Nanomedicine, Medical Image Analysis

Key words: nanoparticles, cell uptake, fluorescence microscopy, high-throughput, machine learning, image segmentation, modelling, Cellpose

Cell Line: HeLa cells

993
Peptide-Functionalized and Drug-Loaded Tomato Bushy Stunt Virus Nanoparticles Counteract Tumor Growth in a Mouse Model of Shh-Dependent Medulloblastoma

L Marchetti, F Novelli, B Tanno, S Leonardi, VM Hizam, C Arcangeli, L Santi, S Baschieri, C Lico, M Mancuso

International Journal of Molecular Sciences (MDPI) Italy , 17 May 2023

Pharmacology, Oncology

Key words: TBSV NPs, drug delivery system, doxorubicin, preclinical study, Ptch1+/− mice, MB therapy

Organism: Mouse

Tissue: Brain

994
Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma

Y Wang, X Xiang, H Chen, L Zhou, S Chen, G Zhang, X Liu, X Ren, J Liu, M Kuang, J Jiang, J She, Z Zhang, R Xue, H Jiang, J Wang, S Peng

Cell Reports Medicine (Cell Press) China , 16 May 2023

Immunology, Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

995
Short‐term toll‐like receptor 9 inhibition leads to left ventricular wall thinning after myocardial infarction

M Lenz, A Kiss, P Haider, M Salzmann, M Brekalo, KA Krychtiuk, O Hamaza, K Huber, C Hengstenberg, BK Podesser, J Wojta, PJ Hohensinner, WS Speidl

ESC Heart Failure (Wiley) Austria , 16 May 2023

Pharmacology, Cardiology

Key words: CXCR2, Infarction, Ischaemia–reperfusion, Neutrophils, TLR9

Organism: Rat

Tissue: Heart

Pathological State: Ischaemia–reperfusion injury

996
Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants

W Bader, C Steinacher, HT Fischer, R Glueckert, J Schmutzhard, A Schrott-Fischer

International Journal of Molecular Sciences (MDPI) Austria , 16 May 2023

Neuroscience

Key words: cochlea implant, IBA1, F4/80, CD163, CD45, immune response, inner ear, hypothermia

Organism: Mouse

Tissue: Ear

997
High expression of peroxisomal D-bifunctional protein in cytosol regulates apoptosis and energy metabolism of hepatocellular carcinoma cells via PI3K/AKT pathway

N Zhang, YQ Wang, C Sun, Y Shi, LG Hou, M Yao, M Hu, XM Wang, PP Ma, WJ Li, LL Jiang

American Journal of Cancer Research (e-Century Publishing) China , 15 May 2023

Oncology

Key words: Peroxisomal D-bifunctional protein, hepatocellular carcinoma, HepG2, apoptosis, energy metabolism, PI3K/AKT pathway

Organism: Human

Tissue: Liver

Pathological State: Cancer

998
Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice

Y Yao, D Lin, Y Chen, L Liu, Y Wu, X Zheng

Inflammation Research (Springer) China , 15 May 2023

Aging

Key words: Microglia, Neuroinflammation, Postoperative cognitive dysfunction, Fluoxetine, Toll-like receptor 4

Organism: Mouse

Tissue: Brain

999
Characterization of Early and Late Damage in a Mouse Model of Pelvic Radiation Disease

R Vitali, F Palone, I De Stefano, C Fiorente, F Novelli, E Pasquali, E Fratini, M Tanori, S Leonardi, B Tanno, E Colantoni, S Soldi, S Galletti, M Grimaldi, AG Morganti, L Fuccio, S Pazzaglia, C Pioli, M Mancuso, L Vesci

International Journal of Molecular Sciences (MDPI) Italy , 15 May 2023

Radiotherapy

Key words: mouse model, intestinal damage, ionizing radiation, intestinal stem cells, fecal markers

Organism: Mouse

Tissue: Colon

Pathological State: Pelvic Radiation Disease

1000
Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice

C Wang, B Zhao, J Zhai, A Wang, N Cao, T Liao, R Su, L He, Y Li, X Pei, Y Jia, W Yue

Cell Death & Disease (Nature) China , 12 May 2023

Stem Cell Research

Key words: Mesenchymal stem cells, Stem-cell research

Organism: Mouse

Tissue: Muscle

Pathological State: Sarcopenia

Results 991 - 1000 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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