Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 821 - 830 of 3421
821
Proteomic profiling of advanced melanoma patients to predict therapeutic response to anti-PD-1 therapy

N Zila, OM Eichhoff, I Steiner, T Mohr, A Bileck, PF Cheng, A Leitner, L Gillet, T Sajic, S Goetze, B Friedrich, P Bortel, J Strobl, R Reitermaier, SA Hogan, JM Martínez-Gómez, R Staeger, F Tuchmann, S Peters, G Stary, M Kuttke, A Elbe-Buerger, C Hoeller, R Kunstfeld, W Weninger, B Wollscheid, R Dummer, LE French, C Gerner, R Aebersold, MP Levesque, V Paulitschke

Clinical Cancer Research (AACR) Austria, Switzerland, Germany , 20 October 2023

Oncology, Pharmacology

Key words: Predictive biomarker, Immunotherapy, Serum depletion, Glycoproteomics, SWATH/DIA mass spectrometry

Organism: Human

Tissue: Skin

Pathological State: Cancer

822
TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD

L Sun, Y Chen, L Xia, J Wang, J Zhu, J Li, K Wang, K Shen, D Zhang, G Zhang, T Shi, W Chen

Oncogene (Nature) China , 20 October 2023

Oncology

Key words: Apoptosis, Extracellular matrix, Gastric cancer, Ubiquitylation

Organism: Human

Tissue: Stomach

Pathological State: Cancer

823
Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma

Z Cai, L Chen, S Chen, R Fang, X Chen, W Lei

Cell Communication and Signaling (Springer) China , 18 October 2023

Oncology

Key words: Single-cell RNA sequencing, Hypopharyngeal squamous cell carcinoma, Tumor microenvironment, Extracellular matrix cancer-associated fibroblast, Precision therapy

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

824
Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization

CY Ko, YY Lin, D Achudhan, JW Chang, SC Liu, CY Lai, YL Huang, CH Tsai, YC Fong, HT Chen, KT Lee, CC Huang, TK Chang, CH Tang

International Journal of Biological Sciences (Ivyspring International Publisher) Taiwan , 18 October 2023

Osteology, Immunology

Key words: Omentin-1, Osteoarthritis, IL-4, M2 macrophage, Anti-inflammation

Organism: Human, Rat

Tissue: Joint Tissue

Pathological State: Osteoarthritis

825
Effect of the Functional VP1 Unique Region of Human Parvovirus B19 in Causing Skin Fibrosis of Systemic Sclerosis

DY Chen, CC Tzang, CM Liu, TM Chiu, JW Lin, PH Chuang, CW Kuo, BS Tzang, TC Hsu

International Journal of Molecular Sciences (MDPI) Taiwan , 18 October 2023

Dermatology

Key words: human parvovirus B19 (B19), systemic sclerosis (SSc), VP1 unique region (VP1u), macrophages, fibrosis

Organism: Human

Tissue: Skin

Pathological State: Human Parvovirus B19 induced Skin Fibrosis

826
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate

O Ertunc, E Smearman, Q Zheng, JL Hicks, JA Brosnan-Cashman, T Jones, C Gomes-Alexandre, L Trabzonlu, AK Meeker, AM De Marzo, CM Heaphy

The Prostate (Wiley) USA , 17 October 2023

Oncology

Key words: chromogenic, diagnostic, in situ hybridization, prostate cancer, telomeres

Organism: Human

Tissue: Prostate

Pathological State: Cancer

827
Danggui Shaoyao San ameliorates the lipid metabolism via the PPAR signaling pathway in a Danio rerio (zebrafish) model of hyperlipidemia

Y Wang, Y Pan, M Hou, R Luo, J He, F Lin, X Xia, P Li, C He, P He, S Cheng, Z Song

Biomedicine & Pharmacotherapy (Elsevier) China , 16 October 2023

Endocrinology

Key words: Danggui Shaoyao San, Hyperlipidemia, PPAR signaling pathway, Danio rerio, Lipid metabolism

Organism: Fish

Tissue: Liver

Pathological State: Hyperlipidemia

828
Role for NLRP3 inflammasome-mediated, Caspase1-dependent response in glaucomatous trabecular meshwork cell death and regulation of aqueous humor outflow

X Feng, Z Chen, W Cheng, C Liu, Q Liu

Heliyon (Cell) China , 15 October 2023

Ophthalmology

Key words: Pyroptosis, NLRP3, ROS, Glaucoma, Human trabecular meshwork cell

Organism: Rat

Tissue: Eye

Pathological State: Glaucoma

829
Light damage induces inflammatory factors in mouse retina and vitreous humor

W Liu, X Zhu, X Ge, Y Chen, DWC Li, L Gong

Molecular Vision (Emory University) China , 15 October 2023

Ophthalmology

Organism: Mouse

Tissue: Eye

Pathological State: Inflammation

830
Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer‐associated fibroblasts

JI Choi, EJ Cho, MJ Yang, HJ Noh, SH Park, S Kim, YS Kim, CO Sung, D Lee

Clinical and Translational Medicine (ncbi.nlm.nih.gov) South Korea , 14 October 2023

Oncology

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

Results 821 - 830 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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