Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 451 - 460 of 3476
451
Tumor-derived extracellular vesicles convey solute transporters to induce bioenergetic dependence shift contributing to treatment resistance

J Hirpara, WL Thuya, SH Cheow, K Fernando, JQ Eu, L Wang, ALA Wong, ELS Fong, AB Ali, Lw Ding, W Zhuoran, YC Lim, S Pervaiz, BC Goh

Theranostics (Ivyspring) Singapore , 30 September 2024

Oncology

Key words: Extracellular Vesicles, TKI-resistance, SLC1A5, Tumor Microenvironment, metabolic reprogramming

Organism: Human

Pathological State: Cancer

Cell Line: HCC827 

452
Engineered 3D human neurovascular model of Alzheimer's disease to study vascular dysfunction

G Pavlou, S Spitz, FM Pramotton, A Tsai, BM Li, X Wang, OM Barr, EC Ko, S Zhang, SJ Ashley, A Maaser-Hecker, SH Choi, M Jorfi, RE Tanzi, RD Kamm

Biomaterials (Elsevier) USA , 28 September 2024

Neuroscience

Key words: Blood-brain barrier, Alzheimer's disease, Neurovascular unit, Perfusable 3D brain in vitro model, Amyloid-β

Pathological State: Alzheimer's disease

Cell Line: human primary brain microvascular endothelial cells

453
The epigenetic-modified downregulation of LOXL1 protein mediates EMT in bladder epithelial cells exposed to benzo [a] pyrene and its metabolite BPDE

R Zou, J Lu, X Bai, Y Yang, S Zhang, S Wu, Z Tang, K Li, X Hua

International Immunopharmacology (Elsevier) China , 27 September 2024

Oncology

Key words: Bladder Cancer, LOXL1, EMT, DNA methylation

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

454
Syntheses of LSD1/HDAC Inhibitors with Demonstrated Efficacy against Colorectal Cancer: In Vitro and In Vivo Studies Including Patient-Derived Organoids

PY Chou, MJ Lai, KK Tsai, LH Cheng, YW Wu, MC Chen, SL Pan, HO Ho, K Nepali, JP Liou

Journal of Medicinal Chemistry (ACS Publications) Taiwan , 25 September 2024

Oncology

Key words: Cells, Genetics, Inhibitation, Inhibitors, Peptides and Proteins

Organism: Human

Tissue: Colon

Pathological State: Cancer

455
Application of Small Animal Ultrasound Imaging Technology for Identification of Polycystic Ovary Syndrome in a Mouse Model

M Ren, T Yang, M Liu, X Ma, B Li, ASM Al-Mughalles, X Pei, S Zhang

Biochemical and Biophysical Research Communications (Elsevier) China , 23 September 2024

Reproductive Medicine

Key words: Ultrasonography, Polycystic ovary syndrome, Letrozole, High-fat diet, Model

Organism: Mouse

Tissue: Ovaries

Pathological State: Polycystic ovary syndrome

456
Network Pharmacology and Metabolomics of Xinnaoxin Tablets for Antioxidant Stress in the Treat-ment of Coronary Heart Disease

F Gao, H Shen, Z Yang, Z Ding, X Zhao, X Liu, B Cui, XC Liu, YX Zhang, QH Guo

Current Science (currentscience.info) China , 20 September 2024

Pharmacology

Key words: Metabolomics; Xinnaoxin tablet; Coronary heart disease; Keap1-Nrf2/HO-1

Organism: Rat

Tissue: Heart

Pathological State: Coronary Heart Disease

457
Functional and Proteomic Dissection of the Contributions of CodY, SigB and the Hibernation Promoting Factor HPF to Interactions of Staphylococcus aureus USA300 with Human Lung Epithelial Cells

X Li, LM Busch, S Piersma, M Wang, L Liu…

Journal of Proteome Research (ACS Publications) The Netherlands, Germany , 20 September 2024

Pulmonology

Key words: Staphylococcus aureus, SigB, CodY, SaHPF, Human Lung Epithelial Cells

Organism: Human

Tissue: Lung

Pathological State: Bacterial Infection

458
BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice with Loss of the Polarity …

MA Shields, AE Metropulos, C Spaulding, KA Alzahrani, T Hirose, S Ohno, TND Pham, HG Munshi

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) USA, Japan , 19 September 2024

Neuroscience, Gastroenterology

Key words: Par3, Inflammation, ADM, Primary Cilia, BET Inhibitors

Organism: Human

Tissue: Pancreas

Pathological State: Pancreatitis

459
Overexpression of NUDT16L1 sustains proper function of mitochondria and leads to ferroptosis insensitivity in colorectal cancer

YS Lin, YC Tsai, CJ Li, TT Wei, JL Wang, BW Lin, YN Wu, SR Wu, SC Lin, SC Lin

Redox Biology (Elsevier) Taiwan , 18 September 2024

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: CRL-1790

460
Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain

H Li, Y Li, T Wang, S Li, H Liu, S Ning, W Shen, Z Zhao, H Wu

Neuroscience Bulletin (Springer) China , 15 September 2024

Neuroscience

Key words: Oxytocin receptor, RNAscope, Expression pattern, Postnatal development

Organism: Mouse

Tissue: Brain

Results 451 - 460 of 3476

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