Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 431 - 440 of 3476
431
High glucose-induced senescence contributes to tubular epithelial cell damage in diabetic nephropathy

D Xu, P Moru, K Liao, W Song, P Yang, D Zang, C Cai, H Zhou

Experimental Gerontology (Elsevier) China , 12 October 2024

Nephrology

Key words: Diabetic nephropathy, Epithelial-mesenchymal transition, Mitochondrial dysfunction, Senescence

Organism: Mouse

Tissue: Kidney

Pathological State: Diabetes

432
Potential role of calcium sulfate/β-tricalcium phosphate/graphene oxide nanocomposite for bone graft application_mechanical and biological analyses

YC Lu, TK Chang, TC Lin, ST Yeh, HS Lin, QP Cheng, CH Huang, HW Fang, CH Huang

Journal of Orthopaedic Surgery and Research (Springer) Taiwan , 12 October 2024

Osteology

Key words: Calcium sulfate, Β-tricalcium phosphate, Graphene oxide, Mechanical strength, Degradation rate, Critical-sized calvarial defect model

Organism: Rat

Tissue: Bone

Pathological State: Calvarial Defect

433
Tumor immune microenvironment dynamics and outcomes of prognosis in non‐muscle‐invasive bladder cancer

R Kamitani, N Tanaka, T Anno, T Murakami, T Masuda, Y Yasumizu, T Takeda, S Morita, T Kosaka, S Mikami, K Matsumoto, M Oya

Cancer Science (Wiley) Japan , 11 October 2024

Oncology

Key words: bladder cancer, FGFR3, microenvironment, PD-1, PD-L1

Organism: Human

Tissue: Bladder

Pathological State: Cancer

434
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency

DC Le, MHT Ngo, YC Kuo, SH Chen, CY Lin, TY Ling, QTT Pham, HK Au, J Myung, YH Huang

Journal of Biomedical Science (Springer) Taiwan, Vietnam , 11 October 2024

Reproductive Medicine

Key words: Placenta mesenchymal stem cell, Estrogen receptor, Primary ovarian insufficiency, Ovarian circadian rhythm disorder, Angiogenin, Exosomal miRNA

Organism: Mouse

Tissue: Ovaries

Pathological State: Primary Ovarian Insufficiency

435
Cytarabine chemotherapy induces meibomian gland dysfunction

R Liu, J Xue, J Han, M Tu, W Wang, Z Chen, X Qian, B Xiao, L Liang

The Ocular Surface (Elsevier) China , 10 October 2024

Oncology, Ophthalmology

Key words: Cytarabine, Meibomian gland dysfunction, PPARγ, FoxO1, Oxidative stress

Organism: Mouse

Tissue: Eye

436
Investigating the role of various extracellular matrix in androgenetic alopecia: Insights from immunostaining and quantitative analysis–A pilot study

IT Lai, YH Chang, CB Chu, PL Chung, CK Hsu, CK Yang

Dermatologica Sinica (Wolters Kluwer) Taiwan , 10 October 2024

Dermatology

Key words: Androgenetic alopecia; extracellular matrix; immunohistochemical staining; scalp stiffness

Organism: Human

Tissue: Skin

Pathological State: Androgenetic Alopecia

437
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury

H Lin, C Ma, X Zhuang, S Liu, D Liu, M Zhang, Y Lu, G Zhou, C Zhang, T Wang, Z Zhang, L Lv, D Zhang, XZ Ruan, Y Xu, R Chai, X Yu, JP Sun, B Chu

Cell Metabolism (Cell Press) China , 09 October 2024

Endocrinology, Hepathology

Key words: GPR56, 17α-hydroxypregnenolone, ferroptosis, liver injury

Organism: Mouse

Tissue: Liver

Pathological State: Ferroptosis-induced liver injury

438
Induced tumor associated autoantibodies (iTAAs) by hapten plus drugs for targeting oncogenic nuclear antigens at sentinel lymph node of pancreatic cancer

L Wang, B Yu, J Zhang, Y Han, G Zheng

Trends in Immunotherapy (EnPress) China , 09 October 2024

Oncology

Key words: tumor associate antigen (TAA), tumor-associated autoantibodies (TAA) induced autologous tumor antibodies (iATA), neu antigens, hapten, hapten induced immunotherapy

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

439
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury

E Du, X Jia, X Li, B Zhang, Y Zhai, F Qin

BMC Molecular and Cell Biology (Springer) China , 09 October 2024

Neuroscience

Key words: Ciclopirox olamine, Retina, Ischemia/reperfusion injury, Neuroprotection

Organism: Rat

Tissue: Eye

Pathological State: Ischemia

440
Visualization of the dentogingival junction using micro‐plastination technique

J Correa‐Aravena, C Panes, N Ponce, A Prado-Sanhueza, D Guzmán, B Vásquez, I Roa, C Veuthey, TS Masuko, NE Ottone

Clinical Anatomy (Wiley) Chile, Brazil , 08 October 2024

Imaging

Key words: dentin, dentogingival junction, enamel, histological stains, micro, plastination, plastinationautofluorescence

Organism: Human

Tissue: Tooth

Results 431 - 440 of 3476

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