Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 3201 - 3210 of 3476
3201
Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice

Krisztina Szalai, Tamara Kopp, Anna Lukschal, Caroline Stremnitzer, Julia Wallmann, Philipp Starkl, Luc Vander Elst, Jean-Marie Saint-Remy, Isabella Pali-Schöll, Erika Jensen-Jarolim

Experimental Dermatology (Wiley) Austria, Belgium , 15 October 2012

Dermatology

Key words: Allergic eczema, atopic eczema, Der p1 and Der p 2, house dust mite, protease activity, recombinant allergens

Organism: Mouse

Tissue: Skin

Pathological State: Eczema

3202
PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas

Daniela Laimer, Helmut Dolznig, Karoline Kollmann, Paul W Vesely, Michaela Schlederer, Olaf Merkel, Ana-Iris Schiefer, Melanie R Hassler, Susi Heider, Lena Amenitsch, Christiane Thallinger, Philipp B Staber, Ingrid Simonitsch-Klupp, Matthias Artaker, Sabine Lagger, Suzanne D Turner, Stefano Pileri, Pier Paolo Piccaluga, Peter Valent, Katia Messana, Indira Landra, Thomas Weichhart, Sylvia Knapp, Medhat Shehata, Maria Todaro, Veronika Sexl, Gerald Höfler, Roberto Piva, Enzo Medico, Bruce A Ruggeri, Mangeng Cheng, Robert Eferl, Gerda Egger, Josef M Penninger, Ulrich Jaeger, Richard Moriggl, Giorgio Inghirami and Lukas Kenner

Nature Medicine (Nature) Austria, USA, UK, Italy , 14 October 2012

Oncology

Key words: Mechanism of action, Non-hodgkin lymphoma, Therapeutics

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

3203
Prospero Homeobox 1 Promotes Epithelial–Mesenchymal Transition in Colon Cancer Cells by Inhibiting E-cadherin via miR-9

Mei-Hsuan Lu, Chao-Cheng Huang, Mei-Ren Pan, Hong-Hwa Chen, Wen-Chun Hung

Clinical Cancer Research (AACR Publications) Taiwan , 08 October 2012

Oncology

Key words: Prospero homeobox 1, matrix metalloproteinase activity, epithelial–mesenchymal transition

Organism: Human

Tissue: Colon

Pathological State: Cancer

3204
Investigation of the Relationship Between Prostate Cancer and MSMB and NCOA4 Genetic Variants and Protein Expression

Liesel M FitzGerald, Xiaotun Zhang, Suzanne Kolb, Erika M Kwon, Ying Ching Liew, Antonio Hurtado-Coll, Beatrice S Knudsen, Elaine A Ostrander, Janet L Stanford

Human Mutation (Wiley) USA, Canada , 04 October 2012

Oncology

Key words: Prostate cancer, MSMB, PSP94, NCOA4

Organism: Human

Tissue: Prostate

Pathological State: Cancer

3205
Hepatology AASLD Abstracts

Hepatology (Wiley) UK , 01 October 2012

Hepathology

3206
γ-secretase inhibitors prevent overgrowth of transplanted neural progenitors derived from human-induced pluripotent stem cells

A Ogura, A Morizane, Y Nakajima, S Miyamoto, and J Takahashi

Stem Cells and Development (Mary Ann Liebert Inc.) Japan , 28 September 2012

Regenerative Medicine

Organism: Mouse

Tissue: Brain

3207
Brief Report: Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223

Yuan-Tsung Li, Shih-Yao Chen, Chrong-Reen Wang, Ming-Fei Liu, Chi-Chen Lin, I-Ming Jou, Ai-Li Shiau, Chao-Liang Wu

Arthritis & Rheumatology (Wiley) Taiwan , 27 September 2012

Rheumatology

Key words: MicroRNA, MiRNA-223, rheumatoid arthritis, osteoarthritis, reverse transcriptase–polymerase chain reaction

Organism: Mouse

Tissue: Joint Tissue, Bone

Pathological State: Rheumatoid Arthritis

3208
A global downregulation of microRNAs occurs in human quiescent satellite cells during myogenesis

Merel Koning, Paul MN Werker, Marja JA van Luyn, Guido Krenning, Martin C Harmsen

Differentiation (Elsevier) The Netherlands , 26 September 2012

Developmental Biology

Key words: Satellite cells, Skeletal muscle, Quiescence, MicroRNA, MicroRNA microarray

Organism: Human

Tissue: Muscle

3209
Male Microchimerism in the Human Female Brain

William F N Chan, Cécile Gurnot, Thomas J Montine, Joshua A Sonnen, Katherine A Guthrie, J Lee Nelson

PLoS One (PLOS) USA , 26 September 2012

Neuroscience

Key words: Alzheimer disease, brain diseases, pregnancy, natural history of disease, amygdala, frontal lobe, washington, Y chromosomes

Organism: Mouse

Tissue: Brain

3210
Improved assessment of frozen/thawed mouse spermatozoa using fluorescence microscopy

AK Diercks, HF Bürgers, A Schwab, J Schenkel

Journal of veterinary science (Kamje Press) Germany , 20 September 2012

Reproductive Medicine

Key words: cryopreservation, fluorescence microscopy, genetically modified (GM) mice, membrane integrity, 3Rs

Results 3201 - 3210 of 3476

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