Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 2381 - 2390 of 3476
2381
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor‐suppressing phenotype

Hong‐Tai Tzeng Ching‐Chin Su Chih‐Peng Chang Wu‐Wei Lai Wu‐Chou Su Yi‐Ching Wang

International Journal of Cancer (Wiley) Taiwan , 01 May 2018

Oncology

Key words: Rab37, ST2, exocytosis, macrophage, tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2382
Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt‑GSK3β and MAPK/ERK signaling cascades

Xiaona Wang Yanyan Zhu Lili Zhu Xinhuan Chen Yanyan Xu Yafei Zhao Yingzhe Shao Feng Li Yanan Jiang Jing Lu Youtian Huang Xiaobin Chang Juan Zhang Xiang Li Kangdong Liu Mingyao Zhao Ziming Dong Jimin Zhao

Oncology Reports (Demetrios A. Spandidos Ed. and Pub.) China , 23 April 2018

Oncology

Key words: Eupatilin, human esophageal cancer, TE1 cells, Akt‑GSK3β, MAPK/ERK

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2383
Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1

Aline Yen LingWanga Charles Yuen YungLoh Shyi-JouChen Huang-KaiKao Cheng-HungLin Sheng-HaoChuang Chin-MingLee Huey-KangSytwu Fu-ChanWei

Molecular Immunology (Elsevier) Taiwan , 23 April 2018

Immunology

Key words: Allograft tolerance, B lymphocyte-induced maturation protein, T cells

Organism: Mouse

Tissue: Skin

Pathological State: Allogeneic Transplantation

2384
IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Wei-Yu Chen, Jenq-Lin Yang, Yi-Hsiu Wu, Lung-Chih Li, Ru-Fang Li, Ya-Ting Chang, Lo-Hsin Dai, Wan-Chen Wang, Ya-Jen Chang

Experimental & Molecular Medicine (Nature) Taiwan , 20 April 2018

Nephrology

Key words: IL-33/ST2 axis, hyperplasia, renal injury, unilateral ureteral obstruction (UUO)

Organism: Mouse

Tissue: Kidney

Pathological State: Acute Kidney Injury

2385
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Stuart Horswell, Tim Chambers

CELL (Cell Press) UK , 19 April 2018

Oncology

Key words: branched evolution, cancer evolution, chromosome instability, deterministic evolution, intratumor heterogeneity, linear evolution, metastasis, punctuated evolution, renal cell cancer, tumor diversity

Organism: Human

Tissue: Kidney

Pathological State: Cancer

2386
Tumor-induced generation of splenic erythroblast-like Ter-cells promotes tumor progression

Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, Fan J, Zhou W, Qiu S, Zhang Y, Dong T, Li N, Jiang Z, Zhu H, Zhang Q, Ma Y, Zhang Q, Wang Q, Yu Y, Li N, Cao X

CELL (Cell Press) China , 19 April 2018

Oncology

Key words: Ter-119, Ter-cell, artemin, cancer immunotherapy, erythroblast-like, hepatocellular carcinoma, prognosis biomarker

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

2387
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, Andrew Rowan, Tim Chambers, Jose I Lopez, David Nicol

CELL (Cell Press) UK , 19 April 2018

Oncology

Key words: chromosome instability, cytoreductive nephrectomy, evolution of metastasis, loss of 9p, metastasectomy, metastasis, oligometastasis, renal cell cancer, solitary metastasis

Organism: Human

Tissue: Kidney

Pathological State: Cancer

2388
Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model

Bin Xing Lauren E Brink Kelly Maers Mara L Sullivan Richard J Bodnar Donna B Stolz Franca Cambi

GLIA (Wiley) USA , 18 April 2018

Neuroscience

Key words: GSK3b, cell death, glia, multiple sclerosis

Organism: Mouse

Tissue: Brain

2389
CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer

Teresa PRaposoabMireia SuecaComescAdeyemiIdowuaBoraAgitaJamesHassallabWakkasFadhilabRobertNicadRupertEckerdTakashiYaoeMohammadIlyas

Experimental & Molecular Medicine (Elsevier) UK , 11 April 2018

Oncology

Key words: CD10, NEP, CALLA, Colorectal cancer, Epithelial-mesenchymal transition, Metastasis

Organism: Human

Tissue: Colon

Pathological State: Cancer

2390
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma

Patrick J Cimino Youngmi Kim Hua-Jun Wu Jes Alexander, Hans-Georg Wirsching Frank Szulzewsky,1 Ken Pitter,7 Tatsuya Ozawa,1,8 Jiguang Wang,9,10,16 Julio Vazquez,11 Sonali Arora,1 Raul Rabadan Ross Levine Franziska Michor and Eric C Holland

Genes and Development (Cold Spring Harbor Laboratory Press) USA , 09 April 2018

Oncology

Key words: glioblastoma, HoxA, homeobox RCAS, chromosome 7 gain

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

Results 2381 - 2390 of 3476

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