Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 1851 - 1860 of 3421
1851
Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP

J Chen, Z Chen, M Liu, T Qiu, D Feng, C Zhao, S Zhang, X Zhang, J Xu

mBio (American Society for Microbiolgy) China , 15 September 2020

Virology

Key words: BIP, Placental Alkaline Phosphatase, Zika Virus, Placental Trophoblast Cells

Organism: Human

Cell Line: U-251 MG, JEG-3, and HK2 cells

1852
IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

SW Lu, HC Pan, YH Hsu, KC Chang, LW Wu, WY Chen, MS Chang

Nature Communications (Nature) Taiwan , 14 September 2020

Oncology

Key words: Interleukins, Pancreatic Cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1853
In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP) 1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

S Granitzer, I Ellinger, R Khan, K Gelles, R Widhalm, M Hengstschläger, H Zeisler, G Desoye, L Tupova, M Ceckova, H Salzer, C Gundacker

Archives of Toxicology (Springer) Austria, Czech Republic , 11 September 2020

Toxicology

Key words: Multidrug Resistance-Associated Protein 1, Methyl Mercury, HTR-8/Svneo, MDCKII, Oxidative Stress, Human Placenta

Organism: Human

Tissue: Placenta

1854
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix

S Taylor, M Whitfield, J Barratt, A Didangelos

The Journal of Immunology (American Association of Immnologists) UK , 11 September 2020

Immunology

Organism: Human

Tissue: Kidney

1855
Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury

S Lu, Y Tian, Y Luo, X Xu, W Ge, G Sun, X Sun

Journal of Advanced Research (Elsevier) China , 09 September 2020

Cardiology

Key words: Myocardial Ischemia-Reperfusion, Macrophage, Iminostilbene, Pyruvate Kinase M2

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

1856
Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis

Z Guan, Z Chen, S Fu, L Dai, Y Shen

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China , 03 September 2020

Neuroscience

Key words: Alzheimer's Disease, Progranulin, Aβ, BACE1, Microglia

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

1857
Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice

LA Perkins, L Nyiranshuti, L Little-Ihrig, JD Latoche, KE Day, Q Zhu, S Tavakoli, P Sundd, EM Novelli, CJ Anderson

Blood Advances (ASH Publications) USA , 03 September 2020

Cardiology

Key words: Adhesions, Biological Markers, Diagnostic Imaging, Integrins, Mice, Monoclonal Antibodies, Positron-Emission Tomography, Selectins, Flow Cytometry, Femur

Organism: Mouse

Tissue: Bone, Spleen

1858
Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft

M Enayati, S Puchhammer, J Iturri, C Grasl, C Kaun, S Baudis, I Walter, H Schima, R Liska, J Wojta, JL Toca-Herrera, BK Podesser, H Bergmeister

Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) Austria , 03 September 2020

Tissue Engineering

Key words: Biodegradation, Mechanical Stability, Macrophages, Thermoplastic Polyurethane, Cell Culture, Rat Model

Organism: Rat

1859
Murine induced pluripotent stem cell‐derived neuroimmune cell culture models emphasize opposite immune‐effector functions of interleukin 13‐primed microglia and macrophages in terms of neuroimmune toxicity

A Quarta, T Meese, Z Pieters, E Van Breedam, D Le Blon, J Van Broeckhoven, S Hendrix, H Goossens, N Hens, Z Berneman, F Van Nieuwerburgh, P Ponsaerts

GLIA (Wiley) Belgium, Germany, Spain, The Netherlands , 31 August 2020

Neuroscience

Key words: Bioluminescence Imaging, Interleukin 13, iPSC, Macrophages, Microglia, Neurotoxicity, Transcriptome

Organism: Human

Cell Line: iPSC‐macrophages

1860
The Secretome of Stressed Peripheral Blood Mononuclear Cells Increases Tissue Survival in a Rodent Epigastric Flap Model

S Hacker, R Mittermayr, D Traxler, C Keibl, A Resch, S Salminger, H Leiss, P Hacker, C Gabriel, B Golabi, R Pauzenberger, P Slezak, M Laggner, M Mildner, W Michlits, HJ Ankersmit

Bioengineering & Translational Medicine (Wiley) Austria , 30 August 2020

Tissue Engineering

Key words: Secretome, Angiogenesis, Flap Surgery, Necrosis Reconstructive Surgery, Tissue Regeneration

Organism: Rat

Tissue: Skin

Results 1851 - 1860 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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