Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 911 - 920 of 3421
911
Integrative Evaluation of the Clinical Significance Underlying Protein Arginine Methyltransferases in Hepatocellular Carcinoma

Y Jiang, S Wei, JM Koo, HJ Kim, W Park, Y Zhang, H Guo, KT Ha, CM Oh, JS Kang, JH Jeong, D Ryu, KJ Kim, Y Jo

Cancers (MDPI) China, South Korea , 20 August 2023

Oncology

Key words: protein arginine methyltransferase, protein methylation, hepatocellular carcinoma, T cell exhaustion, tissue microarray, prognostic marker

Organism: Human

Tissue: Liver

Pathological State: Cancer

912
Cellular Membrane-Engineered Nanovesicles as a Three-Stage Booster to Target the Lesion Core

F Huang, Y Du, Y Chen, Z Qiu, Z Wang, Y Fan, Y Shi, Z Li, K Yang, W Cui, W Jin

Advanced Materials (Wiley) China , 17 August 2023

Pharmacology, Nanomedicine

913
High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach

CM Hsu, KC Chang, TM Chuang, ML Chu, PW Lin, HS Liu, SY Kao, YC Liu, CT Huang, MH Wang, TJ Yeh, YC Gau, JS Du, HC Wang, SF Cho, CE Hsiao, Y Tsai, SY Hsiao, LC Hung, CH Yen, HH Hsiao

Cancers (MDPI) Taiwan, USA , 17 August 2023

Oncology, Pharmacology

Key words: DLBCL, G9a/EHMT2, niclosamide, autophagy, immunohistochemistry, TissueFAXS PLUS, HistoQuest

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

914
Alveolar Ridge Augmentation with a Novel Combination of 3D-Printed Scaffolds and Adipose-Derived Mesenchymal Stem Cells—A Pilot Study in Pigs

CS Lau, J Chua, S Prasadh, J Lim, L Saigo, BT Goh

Biomedicines (MDPI) Singapore, USA , 16 August 2023

Tissue Engineering

Key words: alveolar ridge augmentation, 3D-printed scaffolds, adipose-derived mesenchymal stem cells, tissue engineering, pig model

Organism: Pig

Cell Line: Scaffold

915
An Engineered Adeno-Associated Virus Capsid Mediates Efficient Transduction of Pericytes and Smooth Muscle Cells of the Brain Vasculature

SH Ramirez, JF Hale, S McCarthy, CL Cardenas, KN Udeni Galpayage Dona, KS Hanlon, E Hudry, D De La Cruz, C Ng, S Das, DM Nguyen, J Nammour, RE Bennett, AM Andrews, PL Musolino, CA Maguire

Human Gene Therapy (Mary Ann) USA , 16 August 2023

Neuroscience, Pharmacology

Key words: adeno-associated virus vector, pericytes, smooth muscle cells

Organism: Mouse

Tissue: Brain, Blood Vessels

916
The putative protein kinase Stk36 is essential for ciliogenesis and CSF flow by associating with Ulk4

H Zhang, M Yang, J Zhang, L Li, T Guan, J Liu, X Gong, F Yang, S Shen, M Liu, Y Han

The FASEB Journal (Wiley) China, Ireland , 16 August 2023

Neuroscience

Key words: ependymal cells, hydrocephalus, motile cilia, Stk36, Ulk4, ventriculomegaly

Organism: Mouse

Tissue: Brain

917
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response

S Tan, Z Wang, N Li, X Guo, Y Zhang, H Ma, X Peng, Y Zhao, C Li, L Gao, T Li, X Lian, C Ma

Cell Death & Differentiation (Nature) China , 15 August 2023

Oncology, Immunology

Key words: Cancer microenvironment, Inflammation

Organism: Human

Tissue: Liver

Pathological State: Cancer

918
Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function

B Xiao, D Guo, R Liu, M Tu, Z Chen, Y Zheng, C Liu, L Liang

Investigative Opthalmology & Visual Science (iovs.arvojournals.org) China , 12 August 2023

Ophthalmology

Organism: Mouse

Tissue: Eye

919
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

J Pencik, C Philippe, M Schlederer, E Atas, M Pecoraro, S Grund-Gröschke, WJ Li, A Tracz, I Heidegger, S Lagger, K Trachtová, M Oberhuber, E Heitzer, O Aksoy, HA Neubauer, B Wingelhofer, A Orlova, N Witzeneder, T Dillinger, E Redl, G Greiner, D D’Andrea, JR Östman, S Tangermann, I Hermanova, G Schäfer, F Sternberg, EE Pohl, C Sternberg, A Varady, J Horvath, D Stoiber, TI Malcolm, SD Turner, EE Parkes, B Hantusch, G Egger, S Rose-John, V Poli, S Jain, CWD Armstrong, G Hoermann, V Goffin, F Aberger, R Moriggl, A Carracedo, C McKinney, RD Kennedy, H Klocker, MR Speicher, DG Tang, AA Moazzami, DM Heery, M Hacker, L Kenner

Molecular Brain (BMC) Austria, USA, Switzerland, Czech Republic, Sweden, Spain, UK, Italy, France , 12 August 2023

Oncology

Key words: STAT3, mTORC1, AR, Prostate Cancer, LKB1, AMPK, CREB, Metformin

Organism: Human

Tissue: Prostate

Pathological State: Cancer

920
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery

K Wuputra, MH Tsai, K Kato, CC Ku, JB Pan, YH Yang, S Saito, CC Wu, YC Lin, KH Cheng, KK Kuo, M Noguchi, Y Nakamura, T Yoshioka, DC Wu, CSn Lin, KK Yokoyama

Inflammation and Regeneration (BMC) Taiwan, Japan , 11 August 2023

Cell Biology

Key words: Antioxidation, Aryl hydrocarbon receptor, Dioxin responsive element, Nuclear factor (erythroid-derived 2)-like 2 transcription factor, Jun dimerization protein 2, Oxidative stress, Reactive oxygen species, Transcriptional regulation

Results 911 - 920 of 3421

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