Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 3241 - 3250 of 3476
3241
CD256 can be found in antibody-mediated renal allograft rejection tissues

Xu H, He X, Zhao W, Guo H, Shi Q, Zhu Y, Zhang X

Clinical Laboratory (NCBI) China , 01 June 2012

Transplantation Medicine

Key words: Tumor necrosis factor, Systemic lupus erythematosus, Rheumatoid arthritis, antibody-mediated rejection

3242
Type 2 diabetes mellitus is associated with an imbalance in circulating endothelial and smooth muscle progenitor cell numbers

J van Ark, J Moser, C P H Lexis, F Bekkema, I Pop, I C C van der Horst, C J Zeebregts, H van Goor, B H R Wolffenbuttel, J L Hillebrands

Diabetologia (Springer) The Netherlands , 01 June 2012

Endocrinology

Key words: smc marker gene, smc differentiation, epc count, mature smc, angiogenic cell, fibrous cap, cell subset, smc lineage, mature ecs, vascular repair, atherosclerotic plaque, real-time rt-pcr, repair capacity, endothelial differentiation, cell mobilisation

Organism: Human

Pathological State: Diabetes

Cell Line: PBMCs

3243
Point sur les avancées technologiques en hémocytométrie aux JIB 2011

F Berge, G Maggiore, A Frenkian

IRBM News (Elsevier) France , 01 June 2012

Cytometry

3244
Chemical shift MR imaging methods for the quantification of transcatheter lipiodol delivery to the liver: preclinical feasibility studies in a rodent model

Xiaoming Yin, Yang Guo, Weiguo Li, Eugene Huo, Zhuoli Zhang, Jodi Nicolai, Robert A Kleps, Diego Hernando, Aggelos K Katsaggelos, Reed A Omary, Andrew C Larson

Radiology (Radiological Society of North America) USA , 01 June 2012

Medical Image Analysis

Organism: Rat

Tissue: Liver

3245
Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection

Byung H Chung, Hye J Oh, Shang G Piao, Hyeon S Hwang, In O Sun, Sun R Choi, Hoon S Park, Bum S Choi, Yeong J Choi, Cheol W Park, Yong-SoKim, Mi-La Cho Chul W Yan

Immunology (Wiley) South Korea , 01 June 2012

Immunology

Key words: Acute T-cell-mediated rejection, FOXP3, interleukin-17, regulatory T cell, T helper type 17

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

3246
96. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V.

Der Pathologe (Springer) Germany , 27 May 2012

Pathology

3247
Neural precursors (NPCs) from adult L967Q mice display early commitment to “in vitro” neuronal differentiation and hyperexcitability

Francesca DiFebo, Daniela Curti, Francesca Botti, Gerardo Biella, Paolo Bigini, Tiziana Mennini, Mauro Toselli

Experimental Neurology (Elsevier) Italy , 22 May 2012

Neuroscience

Key words: Neural stem/progenitor cells (NPCs), motoneuron, neurodegeneration, amyotrophic lateral sclerosis, wobbler mouse, sodium channel, hyperexcitability, patch-clamp

Organism: Mouse

Tissue: Brain

3248
Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

John P Leonard, Ann S LaCasce, Mitchell R Smith, Ariela Noy, Lucian R Chirieac, Scott J Rodig, Jian Q Yu, Shankar Vallabhajosula, Heiko Schoder, Patricia English, Donna S Neuberg, Peter Martin, Michael M Millenson, Scott A Ely, Rachel Courtney, Naveed Shaik, Keith D Wilner, Sophia Randolph, Annick D Van den Abbeele, Selina Y Chen-Kiang, Jeffrey T Yap, Geoffrey I Shapiro

Blood (American Society of Hematology) USA , 17 May 2012

Oncology

Key words: Mantle cell lymphoma, cyclin D1–dependent kinase activity, bortezomib, temsirolimus, lenalidomide

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

3249
Snapshot spectral imaging using optimized diffractive optical elements

M De Biasio, T Arnold, A Tortschanoff, A Hermerschmidt, R Leitner

Next-Generation Spectroscopic Technologies (SPIE) Austria, Germany , 17 May 2012

Microscopy

Key words: snapshot, CTIS, DOE, optimization

3250
RTEL1 contributes to DNA replication and repair and telomere maintenance

Evert-Jan Uringa, Kathleen Lisaingo, Hilda A Pickett, Julie Brind'Amour, Jan-Hendrik Rohde, Alex Zelensky, Jeroen Essers, Peter M Lansdorp

Molecular Biology of The Cell (American Society for Cell Biology) Canada, The Netherlands, Australia , 11 May 2012

Cell Biology

Key words: Telomere maintenance, DNA, mRtel1, embryonic stem cells

Organism: Mouse

Cell Line: Embryonic stem cell

Results 3241 - 3250 of 3476

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