08. June 2022

How to Carry Out Complex Characterization of the Tissue Microenvironment

Histology, or the study of tissues, is a valuable realm of research that underpins a plethora of biomedical innovations today. Much of the work in life sciences rely on biological samples such as tissues in order to perform experiments and extract information on biological conditions in humans. The tissue microenvironment, in particular, provides a study subject and research focus that is rich with robust data potentially useful for biomedical applications.

The tissue microenvironment encompasses the dynamic interactions between various cellular phenotypes and other factors within the tissue that make up an organ in the body. Characterizing cells within the native tissue microenvironment can yield important data that is otherwise difficult to curate from studying cells outside of their natural surroundings.

This blog post will briefly summarize how tissue microenvironment characterization is applicable in a cancer case study. This piece will also provide insight into some innovative products and services offered by TissueGnostics to effectively carry out the complex characterization of the tissue microenvironment.

The Use of Tissue Microenvironment Characterization in Cancer Research
Studies into the tissue microenvironment of tumors can help cancer researchers understand how tumors generate and the progression of the disease in a patient. Furthermore, insight derived from the tissue microenvironment characterization of tumors could help develop more effective treatment strategies in cancer.

In a peer-reviewed study published this year in the journal Genes, cancer researchers relied on innovative technology to accomplish complex tissue microenvironment characterization. Various next-generation digital histopathology platforms were explored and evaluated. These advanced systems enabled whole-slide imaging of tissue samples with the combined advantages of image cytometry and cutting-edge deep/machine learning algorithms to provide robust data.

By imaging and quantifying cells as well as multicellular structures within the tumor microenvironment (immune cells, blood vessels, tumor, tumor stroma, CISH, FISH etc.), researchers can identify and classify cancer tissues and predict the future development of the disease in different patients. These capabilities are needed for accurate and detailed tissue microenvironment characterization. This could reveal the molecular underpinnings of cancer that could inform clinical health care professionals about crucial features of the disease.

For more detailed information on the advantages and applications of studies, including the tissue microenvironment, please see our other blog post, What is Tissue Microenvironment Analysis?

TissueGnostics’ Solutions to the Complex Characterization of the Tissue Microenvironment
As a company at the forefront of tissue analysis solutions, TissueGnostics provides efficient and innovative tissue cytometers designed to carry out the complex characterization of the tissue microenvironment. TissueGnostics products offers many advantages when conducting these studies.

With a line of TissueFAXS cytometers that feature advanced characterization abilities, such as multiple modes of whole slide imaging (brightfield, fluorescence, confocal and multispectral), TissueGnostics enables scientists to deeply engage with the tissue microenvironment.

Expert innovators at TissueGnostics are committed to developing client-focused analysis solutions for every tissue cytometry related research question (StrataQuest Apps) while prioritizing the accuracy and reproducibility of data from complex tissue microenvironment characterization studies.

If you are interested in performing complex characterization of the tissue microenvironment within stained tissue samples in your laboratory and any related technologies and services, please reach out to a member of the TissueGnostics team today.


Are you also interested in Using Single Cell Analysis in COVID-19 Immunity Studies?

or in The Diagnostic Potential of Image Cytometry?


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