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IHC Membrane

Unmix up to three markers in IHC/HC slides, segment cells into nucleus, perinuclear area, cytoplasm, and membrane (e.g. HER2/neu), measure up to 20 intensity, statistic, and morphometric parameters per compartment plus membrane intensity and angle.

HER2, breast cancer, immunohistochemistry, automated scoring

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The IHC Membrane App unmixes up to three markers in an IHC or HC digital slide and segments cells into nucleus, and/or perinuclear area and/or cytoplasm, as well as into membrane (e.g. HER2/neu). Each segmented cell compartment is measured for up to 20 intensity, statistic and morphometric parameters. Three more parameters are measured for membrane intensity and angle of staining. All parameters are displayed in scattergrams and histograms and can be exported.

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Original image

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Nuclei and membrane detection

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White Paper

17 Oct, 2025

Integrative Multiomics Approach Unveils Systemic Dysfunction in Colorectal Cancer (CRC)

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White Paper

17 Oct, 2025

Integrative Multiomics Approach Unveils Systemic Dysfunction in Colorectal Cancer (CRC)

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Application Note

14 Oct, 2024

Quantitative Analysis of Cultured Cells

We support the following file formats:

  • TissueFAXS (aqproj)
  • StrataFAXS II (vmic)
  • PreciPoint (vmic, gtif)
  • Generic BigTIFF Import
  • Support for multipage BigTIFF files
  • OME-TIFF
  • JPEG, PNG, BMP, TIFF
  • Zeiss (czi)

  • Hamamatsu NanoZoomer (ndpi)
  • Aperio (svs)
  • Leica (scn)
  • 3D HISTECH Pannoramic
  • Mirax (mrxs)
  • Olympus (vsi)
  • More slide scanners to be added!

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Image

Custom App development

Perfectly tailored image analysis solutions for your research.

You have a specific research question that needs to be answered? We offer custom development of image analysis pipelines for specific tasks, be it detection of cellular phenotypes or quantification of tissue structures. After discussing your goals with one of our experts, you will get a ready-to-use App and be a step closer to an impactful publication.

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TissueGnostics GmbH
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+43 1 216 11 90
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About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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