Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 91 - 100 of 3293
91
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease

L van Olst, B Simonton, AJ Edwards, AV Forsyth, J Boles, P Jamshidi, T Watson, N Shepard, T Krainc, BM Argue, Z Zhang, J Kuruvilla, L Camp, M Li, H Xu, JL Norman, J Cahan, R Vassar, J Chen, RJ Castellani, JA Nicoll, D Boche, D Gate

Nature medicine (Nature) USA, UK, Singapore , 06 March 2025

Neuroscience

Key words: Alzheimer's disease, Molecular neuroscience, Neuroimmunology

Organism: Human

Tissue: Brain

Pathological State: Alzheimer's Disease

92
Compositional and topological determinants of a physiological Ashwell–Morell receptor ligand

J Hintze, R Fraumeni, N de Haan, RL Miller, M Saraswat, Z Yang, H Clausen, JD Marth

Proceedings of the National Academy od Sciences (PNAS) USA, Denmark, The Netherlands , 06 March 2025

Cell Biology

Key words: Ashwell–Morell receptor, lectin receptors, lectin ligands, glycosylation, blood proteostasis

Organism: Mouse

Tissue: Liver

93
2FA-Platform Generates Dual Fatty Acid-Conjugated GLP-1 Receptor Agonist TE-8105 with Enhanced Diabetes, Obesity, and NASH Efficacy Compared to Semaglutide

MT Wong, PH Lin, WC Lin, CJ Peng, JD Wright, HJ Lee, HM Chu, C Lim, TW Chang

Journal of Medicinal Chemistry (ACS Publications) Taiwan , 05 March 2025

Pharmacology

Key words: Anatomy, Biopolymers, Carbohydrates, Peptides and proteins, Rodent models

Organism: Mouse

Tissue: Liver

Pathological State: Obesity

94
Effects of intra-articular applied rat BMSCs expressing alpha-calcitonin gene-related peptide or substance P on osteoarthritis pathogenesis in a murine surgical osteoarthritis model

S Stöckl, S Taheri, V Maier, A Asid, M Toelge, HS Clausen-Schaumann, A Schilling, S Grässel

Stem Cell Research & Therapy (Springer) Germany , 05 March 2025

Osteology

Key words: Osteoarthritis, DMM, SP, αCGRP, BMSC, Nanoct, AFM, Serum marker, Motion analysis

Organism: Mouse

Tissue: Joint Tissue

Pathological State: Osteoarthitis

95
New mouse models for exploring renal tumor extension into the inferior vena cava

X Li, H Li, X Zhao, J Wang, D Li, Q Li, Q Xu, S Wu, Q Liang, S Li, Q Jiao, K Liu, S Du, C Peng, B Wang, L Gu, X Zhang, Q Huang, X Ma

Communications Biology (Nature) China , 05 March 2025

Oncology, Nephrology

Key words: Cancer models, Renal cell carcinoma

Organism: Mouse

Tissue: Kidney

Pathological State: Cancer

96
Impact of POU3F4 mutation on cochlear development and auditory function

J Dang, P Bian, C Chen, C Chen, W Shan, L Cai, Y Li, H Tan, B Xu, M G Y Guo

Cell Communication and Signaling (Springer) China , 05 March 2025

Hearing Science

Key words: POU3F4, Cochlear development, Hearing loss, Mitochondrial dysfunction, Apoptosis, Oxidative phosphorylation, Cochlear malformations

Organism: Mouse

Tissue: Cochlea

97
PD-1 involvement in CD8+ tumor-infiltrating lymphocytes in patients with colonic-derived peritoneal adenocarcinoma

H Hu, M Zhang

Brazilian Journal of Medical and Biological Research (SciELO Brasil) China , 03 March 2025

Oncology

Key words: PD-1; CD8; Colonic-derived peritoneal adenocarcinoma; Recurrence; Flow cytometry; Multiple immunofluorescences

Organism: Human

Tissue: Peritoneum

Pathological State: Cancer

98
cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia

X Ge, X Zhu, W Liu, M Li, Z Zhang, M Zou, M Deng, H Cui, Z Chen, L Wang, X Hu, R Ju, X Tang, X Ding, L Gong

Journal of Neuroinflammation (BMC) China , 01 March 2025

Neuroscience

Organism: Mouse

Tissue: Eye

99
Second harmonic generation microscopy reveals the spatial orientation of glutamine-potentiated liver regeneration after hepatectomy

CC Yen, CS Yen, HW Tsai, MM Yeh…

Hepatology Communications (AASLD) Taiwan, USA , 01 March 2025

Hepatology

Key words: glutamine, hepatectomy, liver regeneration, second-harmonic generation microscopy, two-photon excitation fluorescence

Organism: Mouse

Tissue: Liver

Pathological State: Hepatectomy

100
Single-cell transcriptomics analysis reveals that the tumor-infiltrating B cells determine the indolent fate of papillary thyroid carcinoma

C Li, P Wang, Z Dong, W Cao, Y Su, J Zhang, S Zhao, Z Wang, Z Lei, L Shi, R Cheng, W Liu

Journal of Experimental & Clinical Cancer Research (Springer) China , 01 March 2025

Oncology

Key words: Papillary thyroid carcinoma, Indolent, Tumor-infiltrating B. Germinal center B

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

Results 91 - 100 of 3293
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