Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3293 papers published)

Results 81 - 90 of 3293
81
Akkermansia muciniphila exerts a protective effect on the development of abdominal aortic aneurysm by inhibiting inflammation

S Chen, P Qiu, X Zhou, X Yang, C Bi, S Li, W Su, Y Pan, W Tao, X Wu, S Jia

Journal of Functional Foods (Elsevier) China , 13 March 2025

Neuroscience, Gastroenterology

Key words: Abdominal aortic aneurysm, Akkermansia muciniphila, Inflammation, TLR4, NF-κB

Organism: Mouse

Tissue: Aorta

Pathological State: Inflammation

82
Multi-omics analysis revealed the novel role of NQO1 in microenvironment, prognosis and immunotherapy of hepatocellular carcinoma

Y Tang, H Hu, S Chen, B Hao, X Xu, H Zhu, W Zhan, T Zhang, H Hu, G Chen

Scientific Reports (Nature) China , 12 March 2025

Oncology, Hepatology

Key words: NQO1, Hepatocellular carcinoma, Tumor microenvironment, Prognosis, Immunotherapy

Organism: Human

Tissue: Liver

Pathological State: Cancer

83
Ratio of miRNA-29 to miRNA-199 expression coordinates mesenchymal stem cell repair of bleomycin-induced pulmonary injury

SJ Elliot, DT Anderson-Terhune, B Roos, GA Rubio, X Xia, S Pereira-Simon, P Catanuto, G Civettini, ES Hagen, C Arvanitis, S Shahzeidi, MK Glassberg

Molecular Therapy Nucleic Acids (Cell) USA , 11 March 2025

Pulmonology

Key words: MT: Non-coding RNAs, mesenchymal stem cells, pulmonary fibrosis, microRNA, mechanisms, telomeres

Organism: Mouse

Tissue: Lung

Pathological State: Lung Injury

84
A machine learning-based prognostic signature utilizing MSC proteomics for predicting bladder cancer prognosis and treatment response

X Zhang, P Li, L Ji, Y Zhang, Z Zhang, Y Guo, L Zhang, S Jing, Z Dong, J Tian, L Yang, H Ding, E Yang, Z Wang

Translational Oncology (Elsevier) China , 11 March 2025

Oncology, Urology, Machine Learning

Key words: Mesenchymal stem cell, Proteomics, Bladder cancer, Signature, Prognosis

Organism: Human

Tissue: Bladder

Pathological State: Cancer

85
The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation

S Ghorbanpour, SP Cartland, H Chen, S Seth, RC Ecker, C Richards, D Aksentijevic, MP Padula, L Cole, ME Warkiani, MM Kavurma, L McClements

Journal of Translational Medicine (Springer) Australia , 11 March 2025

Cardiology

Key words: FKBPL, Angiogenesis, Hypoxia, Inflammation, Endothelial dysfunction, Microfluidics

Organism: Mouse

Tissue: Muscle

Pathological State: Ischemia

86
Deep learning imaging analysis to identify bacterial metabolic states associated with carcinogen production

M Orouskhani, S Rauniyar, N Morella, D Lachance, SS Minot, N Dey

Discover Imaging (Springer) USA , 10 March 2025

Medical Image Analysis

Key words: Colorectal cancer, Microbiome, Deoxycholic acid, Deep learning

Organism: Bacteria

Tissue: Whole Organism

87
Understanding degradation mechanism for long-term natural weathering of building silicone sealant to guide future façade design, inspection, and accelerated testing methods

FB de Souza, J Bautista, A Giam, CW Wong, SD Pang

Polymer Degradation and Stability (Elsevier) Singapore , 09 March 2025

Material Science

Key words: Façade materials, Silicone sealant, Long-term weathering exposure, Molecular spectroscopy, Microscopy, Mechanical properties

88
Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation Runch

XJ Liu, YB Jia, CH Wu, XX Wang, KM Yang, X Yao, JH Ling

World Journal of Gastroenterology (Baisideng Publishing Group) China , 07 March 2025

Gastroenterology

Organism: Human

Tissue: Colon

Pathological State: Functional Constipation

89
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan

L Jayne, AP Lavin-Peter, J Roessler, A Tyshkovskiy, M Antoszewski, E Ren, A Markovski, S Sun, H Yao, VG Sankaran, VN Gladyshev, RT Brooke, S Horvath, EC Griffith, S Hrvatin

Nature Aging (Nature) USA , 07 March 2025

Aging

Key words: Ageing, DNA methylation, Metabolism, Neuroscience

Organism: Mouse

Tissue: Brain

Pathological State: Aging

90
Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy

HL Chou, IL Lin, YT Chen, WT Chang, A Yu, WC Chen, CY Wu, SJ Chiou, CW Shu, CC Chiu, PF Liu

Cancer Cell International (Springer) Taiwan , 07 March 2025

Oncology

Key words: Lung cancer, Autophagy impairment, CPT, Aniline, TFPA, Oxidative stress

Organism: Human

Pathological State: Cancer

Cell Line: A549

Results 81 - 90 of 3293
conact bus
WANT TO KNOW MORE?
CONTACT US »
Blog update spatial
BLOG UPDATE
An Introduction to Spatial Tissue Cytometry

Cytometry encompasses several methods for investigating cells, such as their count, cell cycle state, phenotype, morphology, size ...

NEWS
NEW Boxed Cytometer - Colubris

We have a lot of exciting plans to share for our big birthday, but we also have many important milestones to reflect on and remember...

Festival Hacks
Subscribe to our scientific Infoletter
Subscribe to Newsletter
App Showcase
APP SHOWCASE
IHC IMMUNE SATUS IN SITU

The IHC Immune Status in Situ App uses the AI classifier to segment tissue into morphological entities such as tumor, stroma, and lymphocyte clusters. It further identifies single cells ...

Publications
TOOLS
Reference Publications

Explore our online database of reference publications to find tout how tissue cytometry can elevate your research

Appcenter
TOOLS
StrataQuest Appcenter

Explore our vast catalog of analysis solutions in our Strataquest Appcenter and get inspired by the variety of applications.

Nadine Bayer
TG ACADEMY WEBINAR
The Effect of Stem Cell Transplantation on Skin Microorganisms
Watch Webinar
Nadine Bayer, PhD
Medical University
of Vienna
Eurolab Article
ARTICLE
Spatial Tissue Cytometry: Success Stories - Eurolab Article

Read about tissue cytometry's potential in understanding the complexities of cell populations in the tissue environment

previous arrow
next arrow

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

Keep in Touch

Be the first to hear about the latest scientific updates



We use cookies

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies).
You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.

Ok Decline
More information