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Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 751 - 760 of 3476
751
Modified Goldner Trichrome for Non-decalcified Mineralized Tissue Plastinated and Embedded in Resin.

C Panes, N Ponce, NE Ottone, I Valdivia-Gandur, V Beltrán, B Vásquez

International Journal of Morphology (Chilean Society of Anatomy) Chile , 01 February 2024

Biological Methods

Key words: Trichrome staining; Plastic resins; Hard Tissue histology

Organism: Dog, Rabbit

752
Urban Particulate Matter Triggers Meibomian Gland Dysfunction

M Tu, R Liu, J Xue, B Xiao, J Li, L Liang

Investigative Ophthalmology & Visual Science (ARVO Journals) China , 01 February 2024

Ophthalmology

Organism: Mouse

Tissue: Eye

Pathological State: Meibomian Gland Dysfunction

753
Efficacy and safety of mTOR inhibition in cutaneous sarcoidosis: a single-centre trial

A Redl, K Doberer, L Unterluggauer, L Kleissl, C Krall, C Mayerhofer, B Reininger, V Stary, N Zila, W Weninger, T Weichhart, C Bock, T Krausgruber, G Stary

The Lancet Rheumatology (The Lancet) Austria , 01 February 2024

Pharmacology

Organism: Human

Tissue: Skin

Pathological State: Sarcoidosis

754
Radiotherapy Resistance of 3D Bioprinted Glioma via ITGA2/P‐AKT Signaling Pathway

D Liu, H Tian, H Li, J Nie, Z Han, G Tang, P Gao, H Cheng, X Dai

Advanced Healtcare Materials (Wiley) China , 30 January 2024

Oncology

Key words: 3D bioprinting, glioma, ITGA2, p-AKT, radiotherapy resistance

Organism: Human

Pathological State: Cancer

Cell Line: GSC23

755
Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis

W Chen, B Jin, C Cheng, H Peng, X Zhang, W Tan, R Tang, X Lian, H Diao, N Luo, X Li, J Fan, J Shi, C Yin, J Wang, S Peng, L Yu, J Li, RQ Wu, DM Kuang, GP Shi, Y Zhou, F Wang, X Jiang

Annals of the Rheumatic Diseases (BMJ Journals) China , 30 January 2024

Nephrology

Organism: Human

Tissue: Kidney

Pathological State: Luphus nephritis

756
Neoadjuvant chemotherapy-induced remodeling of human hormonal receptor-positive breast cancer revealed by single-cell RNA sequencing

F Jia, S Sun, J Li, W Wang, H Huang, X Hu, S Pan, W Chen, L Shen, Y Yao, S Zheng, H Chen, W Xia, H Yuan, J Zhou, T Zhang, B Zhang, J Huang

Cancer Letters (Elsevier) China , 30 January 2024

Oncology, Pharmacology

Key words: HR+ breast cancer, Neoadjuvant chemotherapy, Tumor microenvironment, Chemotherapy resistance, Single cell sequencing

Organism: Human

Tissue: Breast

Pathological State: Cancer

757
Neutralizing IL-16 enhances the efficacy of targeting Aurora-A therapy in colorectal cancer with high lymphocyte infiltration through restoring anti-tumor immunity

SJ Yang, ST Chang, KC Chang, BW Lin, KY Chang, YW Liu, MD Lai, LY Hung

Cell Death & Disease (Nature) Taiwan , 30 January 2024

Oncology, Immunology

Key words: Cancer, Immunology

Organism: Human, Mouse

Pathological State: Cancer

Cell Line: CT26, MC38, HCT116, 4T1

758
FLIP (C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress

JD Tischler, H Tsuchida, R Bosire, TT Od, A Park, RO Adeyemi

Nature Communications (Nature) USA , 29 January 2024

Oncology

Key words: Breast Cancer, Homologous recombination, Proteasome, Stalled forks

Organism: Human

Pathological State: Cancer

Cell Line: U2OS 

759
The Influence of Computed Tomography Contrast Agent on Radiation-Induced Gene Expression and Double-Strand Breaks

S Schüle, F Bunert, C Hackenbroch, M Beer, P Ostheim, S Stewart, M Port, H Scherthan, M Abend

Radiation Research (Radiation Research Society) Germany , 29 January 2024

Imaging, Molecular Biology

760
New insight into prurigo nodularis: Proadrenomedullin N‐terminal 20 peptide mediates mouse mast cell activation via Mrgprb2

Y Shao, Z Xiao, Y Jin, Y Zhu, Y Shen, T Jin, H Tang, D Wang

Skin Research and Technology (Wiley) China , 29 January 2024

Dermatology, Immunology

Key words: chronic pruritus; mas-related G-protein-coupled receptor X2; mast cells; proadrenomedullin N-terminal 20 peptide; prurigo nodularis

Organism: Human

Tissue: Skin

Pathological State: Inflammation

Results 751 - 760 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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