Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3259 papers published)

Results 621 - 630 of 3259
621
Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report

AI Giotakis, A Runge, J Dudas, R Glueckert, T Gottfried, VH Schartinger, J Klarer, A Randhawa, E Caimmi, H Riechelmann

BMC cancer (Springer) Austria, USA , 27 November 2023

Oncology, Cell Biology

Key words: Image cytometry, Fluorescent antibody technique, Epithelial cells, Connective tissue, Leukocytes, Oropharyngeal neoplasms, Human papilloma virus

Organism: Human

Pathological State: Cancer

622
Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease

J Strobl, LM Gail, L Krecu, S Madad, Lisa Kleissl, L Unterluggauer, A Redl, K Brazdilova, S Saluzzo, P Wohlfarth, HA Knaus, M Mitterbauer, W Rabitsch, M Haniffa, G Stary

British Journal of Dermatology (Oxford Academic) Austria, UK , 27 November 2023

Immunology, Dermatology

Organism: Human

Tissue: Skin

Pathological State: Graft-versus-Host Disease

623
Mitoguardin-2 promotes cell proliferation by activating AKT and regulating Hippo/YAP1 signaling pathway in ovarian granulosa cells

MQ Yan, BH Zhu, XH Liu, YM Yang, XY Duan, Y Wang, H Sun, M Feng, T Li, XM Liu

Cell Death & Disease (Nature) China , 27 November 2023

Reproductive Medicine

Key words: Cell proliferation, HIPPO signalling, Infertility, Mitochondria

Organism: Mouse

Tissue: Ovaries

624
Double‐Orthogonal Gradient‐Based High‐Throughput Screening Platform for Studying Cell Response Toward Combined Physicochemical Biomaterial Properties

TAB van der Boon, LE Tromp, L Ge, L Yang, CF Guimaraes, PT Kühn, Q Zhou, RA Bank, TG van Kooten, P van Rijn

Small Science (Wiley) The Netherlands, China , 27 November 2023

Tissue Engineering

Key words: biointerfaces, combinatorial gradients, high-throughput screenings, materiobiology, stem cells

Organism: Human

Cell Line: hBM-MSCs 

625
Acute expression of human APOBEC3B in mice results in RNA editing and lethality

A Alonso de la Vega, NA Temiz, R Tasakis, K Somogyi, L Salgueiro, E Zimmer, M Ramos, A Diaz-Jimenez, S Chocarro, M Fernández-Vaquero, B Stefanovska, E Reuveni, U Ben-David, A Stenzinger, T Poth, M Heikenwälder, N Papavasiliou, RS Harris, R Sotillo

Genome Biology (Springer) Germany, USA, Israel , 24 November 2023

Genetics

Key words: APOBEC3B, RNA editing, Mutations, Mouse models, DNA damage

Organism: Mouse

Tissue: Liver, Pancreas, Intestine, Lung, Spleen

626
Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8+ exhausted-like T cells

S Li, K Li, K Wang, H Yu, X Wang, M Shi, Z Liang, Z Yang, Y Hu, Y Li, H Li, S Cheng, L Ye, Y Yang

Nature Communications (Nature) China , 24 November 2023

Oncology, Radiotherapy

Key words: Cancer therapy, Hepatocellular carcinoma, Radiotherapy, Tumour immunology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

627
Brief Review of the Origins of Plastination

NE Ottone

Advances in Plastination Techniques (Springer) , 23 November 2023

628
Epoxy Sheet Plastination Technique

NE Ottone

Advances in Plastination Techniques (Springer) , 23 November 2023

629
Improved cardioprotective effect of 3‐nitro‐N‐methyl salicylamide solution after a prolonged preservation time of rat heart

S Wang, W Liu, S Liu, J Li, Y Geng, Y Zhao

Clinical and Experimental Pharmacology and Physiology (Wiley) China , 23 November 2023

Cardiology

Organism: Rat

Tissue: Heart

Pathological State: Myocardial injury

630
Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments

H Chen, J Sameshima, S Yokomizo, T Sueyoshi, H Nagano, Y Miyahara, T Sakamoto, S Fujii, T Kiyoshima, T Guy, S Nakamura, M Moriyama, N Kaneko, S Kawano

Frontiers in Immunology (Frontiers Media S.A.) Japan, UK , 23 November 2023

Immunology, Oncology

Key words: oral squamous cell carcinoma, CD4+ cytotoxic T lymphocytes, CTLA-4, T cell dysfunction, CXCL13, double negative B cells

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

Results 621 - 630 of 3259
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