Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3259 papers published)

Results 591 - 600 of 3259
591
Renoprotective effects of extracellular fibroblast specific protein 1 via nuclear factor erythroid 2-related factor-mediated antioxidant activity

N Takahashi, S Yokoi, H Kimura, H Naiki, T Matsusaka, Y Yamamoto, K Nakatani, K Kasuno, M Iwano

Scientific Reports (Nature) Japan , 18 December 2023

Nephrology

Key words: Medical research, Nephrology

Organism: Mouse

Tissue: Brain

592
Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling

Y Wang, M Yao, C Li, K Yang, X Qin, L Xu, S Shi, C Yu, X Meng, C Xie

Experimental Hematology & Oncology (BMC) China , 16 December 2023

Oncology

Key words: KRASG12C, c-Myc, PLK1, LncRNA, ST8SIA6-AS1, Drug resistance

Organism: Human

Pathological State: Cancer

Cell Line: NCI-H358, NCI-H1373, NCI-H23, SW1573, MIA PaCa-2, SW1463

593
Melatonin exhibits partial protective effects against gemcitabine-and cisplatin-induced kidney and reproductive injuries in mice

SC Wang, HC Hsu, YC Chang, CY Yu, CT Liu, WW Sung

Aging (Impact Journals) Taiwan , 14 December 2023

Nephrology, Reproductive Medicine

Key words: melatonin, hormone, testosterone, sperm, chemotherapy

Organism: Mouse

Tissue: Testis, Kidney

594
In silico analyses of pan-squamous cell carcinoma unveiled the immunological implications of MRPL13, which had previously been under-recognized

Y Liang, S He, Y Tan, Q Liu, F Zhao, T Liu, C Huang, X Lu, S Zheng

Heliyon (Cell) China , 14 December 2023

Oncology, Immunology

Key words: MRPL13, Pan-squamous cell carcinoma, Bioinformatics analysis, Prognostic, CD8+ T-cell infiltration

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

595
Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex

N Cheng, Q Dong, Z Zhang, L Wang, X Chen, C Wang

Neuron (Cell Press) China , 14 December 2023

Neuroscience

Key words: retrosplenial, egocentric, dendrite, spine, goal, context, landmark

Organism: Mouse

Tissue: Brain

596
Static Magnetic Field Reduces Intracellular ROS Levels and Protects Cells Against Peroxide-Induced Damage: Suggested Roles for Catalase

ECG Frachini, JB Silva, B Fornaciari, MS Baptista, H Ulrich, DFS Petri

Neurotoxicity Research (Springer) Brazil , 14 December 2023

Neuroscience

Key words: External magnetic field, Oxidative stress, Neuroprotection, SH-SY5Y cells, Cell proliferation

Organism: Human

Cell Line: SH-SY5Y

597
ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-Guided Analysis

VA Arrieta, J Duerinck, KB Burdett, KJ Habashy, W Geens, A Gould, JK Schwarze, C Dmello, KS Kim, R Saganty, L Chen, A Moscona, M McCord, C Lee-Chang, CM Horbinski, H Zhang, R Stupp, B Neyns, AM Sonabend

Clinical Cancer Research (AACR) Belgium, USA, Mexico , 13 December 2023

Oncology, Pharmacology

Organism: Human

Tissue: Brain

Pathological State: Cancer

598
Chlamydia suis survival in dust: First insights–A short communication

C Unterweger, M Koch, S Winkler, S Hammer, A Oppeneder, A Ladinig

Research in Veterinary Science (Elsevier) Austria , 13 December 2023

Microbiology

Key words: Chlamydia suis, Pigs, Dust, Transmission, Disinfection, Viability

Pathological State: Chlamydia infection

Cell Line: LLC-MK2 cells (Rhesus monkey kidney cell line)

599
The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development

MF Chen, CC Hu, YH Hsu, YC Lin, KL Chen, SWN Ueng, Y Chang

Bone & Joint Research (The British Editorial Society of Bone & Joint Surgery) Taiwan , 12 December 2023

Osteology

Key words: Osteoarthritis, EDIL3, Chondrocyte, Extracellular matrix, Cartilage, osteoarthritic changes, cartilage tissues, extracellular matrix, chondrocytes, antibodies, interleukin, aggrecan, pro-inflammatory cytokines, OARSI, subchondral bone plate

Organism: Human

Tissue: Bone

Pathological State: Osteoarthritis

600
Differential effects of microRNAs miR‐21, miR‐99 and miR‐145 on lung regeneration and inflammation during recovery from influenza pneumonia

JWJ Ong, KS Tan, JJX Lee, JE Seet, HW Choi, SG Ler, J Gunaratne, T Narasaraju, L-T Sham, V Patzel, VT Chow

Journal of Medical Virology (Wiley Online Library) Singapore, India, UK , 12 December 2023

Pulmonology

Key words: influenza, lung regeneration, microRNAs, miR-21, mi-99a, miR-145, pneumonia, proliferating AT2 cells, RNA sequencing, stem cells

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

Results 591 - 600 of 3259
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