Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3219 papers published)

Results 51 - 60 of 3219
51
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring

X Cheng, Y Xue, H Wang, Z Ma, N Hu, C Zhang, Y Gao, R Fan, L Hu, J Li, D Zhang, J Huang, S Fang, R Xiao, Y He, T Luo, L Zheng

Ecotoxicology and Enviormental Safety (Elsevier) China , 03 January 2025

Reproductive Medicine

Key words: Polystyrene nanoplastics, Primordial follicles, Maternal exposure, Reproductive damage, Progeny

Organism: Mouse

Tissue: Ovaries

Pathological State: Nanoplastic

52
Lung cancer–intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg cell–dependent CD8+ T-cell exclusion

E Torres-Mejia, S Weng, CA Whittaker, KB Nguyen, E Duong, L Yim, S Spranger

Cancer Immunology Research (AACR) USA , 02 January 2025

Oncology

Key words: Tumor microenvironment, T cell exclusion, tumor vasculature, checkpoint blockade therapy, non-small cell lung cancer, tumor-intrinsic SOX2 signaling pathway, regulatory T cells

Organism: Human

Tissue: Lung

Pathological State: Cancer

53
C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment

J Zhu, X Zhang, L Li, H Yang, H Liu, D Wu, Z Liu, B Liu, T Shen

Ecotoxicology and Enviormental Safety (Elsevier) China , 02 January 2025

Pulmonology

Organism: Mouse

Tissue: Lung

Pathological State: Fibrosis

54
FoxC1 activates Notch3 signaling to promote the inflammatory phenotype of keloid fibroblasts and aggravates keloid

Y Wang, Z Xia, W Wang, J Zhang, C Hu, F Wang, F Zhu, LS Fang, Jwang, X Li

Experimental Cell Research (Elsevier) China , 01 January 2025

Dermatology

Key words: Keloid, FoxC1, Notch3, Fibroblasts

Organism: Mouse, Human

Tissue: Skin

Pathological State: Keloid

55
Insights in glial cell pathology and multiple sclerosis: from an-omics and hiPSC perspective

M Wijering

(University of Groningen) The Netherlands , 01 January 2025

Neuroscience

Organism: Human

Tissue: Brain

Pathological State: Multiple Sclerosis

56
Long Afterglow Hybrid Nanoplatform for Integrated NIR-Ⅱ Imaging Diagnosis and Triple-synergistic Treatment of Choroidal Melanoma

L Yang, Y Wang, Y Guo, K Ge, P Wu, Y Du, Y Wang. Y Tang, W Zhang, W Liu

Talanta (Elsevier) China , 30 December 2024

Oncology

Key words: Long afterglow material, NIR-II imaging, Photothermal and photodynamic therapy, Sustained-release chemotherapy drugs, Choroidal melanoma

Organism: Mouse

Tissue: Eye

Pathological State: Cancer

57
Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNVIP neurons

Y Zhang, W Wang, J Li, D Zhao, Y Shu, X Jia, Y Wang, X Cheng, L Wang, J Cheng

Communications Biology (Nature) China , 28 December 2024

Neuroscience

Key words: Circadian rhythms and sleep, Molecular medicine

Organism: Mouse

Tissue: Brain

Pathological State: Chemical Exposure

58
Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment

X Liu, D Xu, C Zhou, Y Zhong, H Geng, C Huang, Y Shen, X Xia, C Wang, C Zhu, H Cao

Journal of Translational Medicine (BMC) China , 27 December 2024

Oncology

Key words: Gastric cancer (GC), PD-1 + Treg/PD-1 + CD8 ratio, Tertiary lymphoid structure (TLS), Neoadjuvant therapy, Conversion therapy

Organism: Human

Tissue: Stomach

Pathological State: Cancer

59
Hyperactive delta isoform of PI3Kinase enables long distance regeneration of adult rat corticospinal tract

K Kristyna, P Zuzana, K Lydia, S Stepanka, N Bart, H Radovan, H Vit, MU Lucia, T Rostislav, KC Jessica, J van den Herik, V Joost, E Richard, FW James, J Pavla

Molecular Therapy (Cell) Czech Republic, UK, Slovakia, The Netherlands , 27 December 2024

Neuroscience

Key words: pinal cord, axon regeneration, signalling, PI3K, pS6, skilled paw reaching, electrophysiology, c-Fos

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord injury

60
Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK-mediated mitochondria protection in early diabetic retinopathy

J Liu, Y Zhang, X Xu, X Dong, Y Pan, X Sun, Y Luo

Pharmacological Research (Elsevier) China , 26 December 2024

Pharmacology

Key words: Ginsenoside Ro, Endothelial cell, Epac1/APMK pathway, Mitochondria damage, Diabetic retinopathy

Organism: Mouse

Tissue: Eye

Pathological State: Diabetes

Results 51 - 60 of 3219
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