Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3259 papers published)

Results 3201 - 3210 of 3259
3201
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

Andreas Weigert, Susanne Schiffmann, Divya Sekar, Stephanie Ley, Heidi Menrad, Christian Werno, Sabine Grosch, Gerd Geisslinger, Bernhard Brüne

International Journal of Cancer (Wiley) Germany , 28 May 2009

Oncology

Key words: Cancer, angiogenesis, macrophages, sphingolipids, inflammation

3202
Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases

Hannes Neuwirt, Martin Puhr, Frédéric R Santer, Martin Susani, Wolfgang Doppler, Gemma Marcias, Veronika Rauch, Maria Brugger, Alfred Hobisch, Lukas Kenner, Zoran Culig

The American Journal of Pathology (Elsevier) Austria , 01 May 2009

Oncology

Key words: Prostate cancer, gastric carcinoma, neck cancer, melanoma, chronic myleoid leukemia

3203
Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

Franco Fortunato, Heinrich Bürgers, Frank Bergmann, Peter Rieger, Markus W Büchler, Guido Kroemer, Jens Werner

Gastroenterology (Elsevier) Germany, France , 09 April 2009

Gastroenterology

Organism: Rat

Tissue: Pancreas

Pathological State: Pancreatitis

3204
Coexpression of the melatonin receptor 1 and nestin in human breast cancer specimens

O Rögelsperger, C Ekmekcioglu, W Jäger, M Klimpfinger, R Königsberg, D Krenbek, F Sellner, T Thalhammer

Journal of Pineal Research (Wiley) Austria , 30 March 2009

Neuroscience

Key words: Breast cancer, MT1–nestin coexpression, immunofluorescence, quantification, TissueQuest

Organism: Human

Tissue: Breast

Pathological State: Cancer

3205
Technical and Methodological Basics of Slide-Based Cytometry

Mittag A Bocsi J, Laffers W, Gerstner AOH

Cellular Diagnostics (Karger) Germany , 11 March 2009

Cytometry

3206
Monocytes/macrophages in kidney allograft intimal arteritis: no association with markers of humoral rejection or with inferior outcome

Nicolas Kozakowski, Georg A Böhmig, Markus Exner, Afschin Soleiman, Nicole Huttary, Katalin Nagy-Bojarszky, Rupert C Ecker, Željko Kikic, Heinz Regele

Nephrology Dialysis Transplantation (Oxford University Press) Austria , 17 February 2009

Transplantation Medicine

Key words: Intimal arteritis, kidney allograft, lymphocyte, macrophage, monocyte

Organism: Human

Tissue: Blood Vessels

Pathological State: Allogeneic Transplantation

3207
Human Rhinovirus Type 2 Uncoating at the Plasma Membrane Is Not Affected by a pH Gradient but Is Affected by the Membrane Potential

Ursula Berka, Abdul Khan, Dieter Blaas, Renate Fuchs

Journal of Virology (American Society for Microbiology) Austria , 04 February 2009

Virology

Organism: Human

Pathological State: Rhinovirus Infection

Cell Line: HeLa cells

3208
Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions

Verónica-Haydée Lugo-Martínez, Constance S Petit, Stéphane Fouquet, Johanne Le Beyec, Jean Chambaz, Martine Pinçon-Raymond, Philippe Cardot, Sophie Thenet

Gastrointestinal and Liver Physiology (APS Journals) France , 01 February 2009

Gastroenterology

Key words: Intestinal epithelium

Organism: Mouse

Tissue: Intestine

3209
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

Arthur Liesz, Elisabeth Suri-Payer, Claudia Veltkamp, Henrike Doerr, Clemens Sommer, Serge Rivest, Thomas Giese and Roland Veltkamp

Nature Medicine (Nature) Germany, Canada , 25 January 2009

Immunology, Neuroscience

Organism: Mouse

Cell Line: Regulatory T cells, Lymphocytes, Granulocytes, Microglia

3210
The role of nanoparticle size in hemocompatibility

Andrea Mayer, Maria Vadon, Beate Rinner, Alexandra Novak, Reinhold Wintersteigerc, Eleonore Fröhlich

Toxicology (Elsevier) Austria , 22 January 2009

Toxicology

Key words: Nanotoxicology, Human blood, In vitro test system, Polystyrene particles, Particle siz, Surface charge, Nanoparticles

Organism: Human

Cell Line: Whole Blood

Results 3201 - 3210 of 3259
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