Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3259 papers published)

Results 3181 - 3190 of 3259
3181
Management of recurrence of symptoms of gastroesophageal reflux disease: synergistic effect of rebamipide with5 mg lansoprazole

N Yoshida, K Kamada, N Tomatsuri, T Suzuki, T Takagi, H Ichikawa, T Yoshikawa

Digestive diseases and Sciences (Springer) , 01 January 2010

3182
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice

Lisa Sevenich, Uta Schurigt, Kathrin Sachse, Mieczyslaw Gajda, Fee Werner, Sebastian Müller, Olga Vasiljeva, Anne Schwinde, Nicole Klemm, Jan Deussing, Christoph Peters, Thomas Reinheckel

PNAS (PNAS) Germany , 22 December 2009

Oncology

Key words: Lysosome mammary, adenocarcinoma, mouse model protease

3183
In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

Karin Montet-Abou, Jean-Luc Daire, Jean-Noël Hyacinthe, Manuel Jorge-Costa, Kerstin Grosdemange, François Mach, Alke Petri-Fink, Heinrich Hofmann, Denis R Morel, Jean-Paul Vallée, Xavier Montet

European Heart Journal (Oxford University Press) Switzerland , 19 December 2009

Cardiology

Key words: Magnetic resonance imaging, Iron oxide nanoparticles, Inflammation, Myocardial infarction

3184
Carbogen Gas–Challenge BOLD MR Imaging in a Rat Model of Diethylnitrosamine-induced Liver Fibrosis

Ning Jin, Jie Deng, Tamuna Chadashvili, Yue Zhang, Yang Guo, Zhuoli Zhang, Guang-Yu Yang, Reed A Omary, Andrew C Larson

Radiology (Radiological Society of North America) USA , 14 December 2009

Hepathology

3185
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement

Alexander T Bauer, Heinrich F Bürgers, Tamer Rabie, Hugo H Marti

Journal of Cerebral Blood Flow and Metabolism (SAGE Journals) Germany , 09 December 2009

Neuroscience

Key words: blood–brain barrier, hypoxia, in vivo, matrix metalloproteinase, occludin, vascular permeability

3186
Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells

Frédéric R Santer, Kamilla Malinowska, Zoran Culig, Ilaria T Cavarretta

Endocrine-Related Cancer (Society for Endocrinology) Austria , 04 December 2009

Oncology

Key words: IL-6 receptor, phosphotidylinositol 3-kinase, prostate cancer,

3187
Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice

Monica Musteanu, Leander Blaas, Markus Mair, Michaela Schlederer, Martin Bilban Stefanie Tauber, Harald Esterbauer,Mathias Mueller, Emilio Casanova, Lukas Kenner, Valeria Poli, Robert Eferl

Gastroenterology (Elsevier) Austria, Italy , 04 December 2009

Oncology

Key words: APC, CEACAM1, Colorectal Cancer

3188
Mimotope vaccination for therapy of allergic asthma: anti-inflammatory effects in a mouse model

J Wallmann, MM Epstein, P Singh, R Brunner, K Szalay, L El-Housseini, I Pali-Scholl, E Jensen-Jarolim

Clinical and Experimental Allergy (Wiley) Austria , 02 December 2009

Allergy Research

Key words: T lymphocytes, grass pollen allergens, Keyhole limpet haemocyanin (KLH)

3189
Disruption of the growth hormone—Signal transducer and activator of transcription 5—Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis

Leander Blaas, Jan-Wilhelm Kornfeld, Daniel Schramek, Monica Musteanu, Gernot Zollner, Judith Gumhold, Franziska van Zijl, Doris Schneller, Harald Esterbauer, Gerda Egger, Markus Mair, Lukas Kenner, Wolfgang Mikulits, Robert Eferl, Richard Moriggl, Josef Penninger, Michael Trauner, Emilio Casanova

Hepatology (Wiley) Austria , 30 November 2009

Hepathology

Key words: Liver Failure, Cirrhosis, Portal Hypertension

Pathological State: Liver Fibrosis

3190
Transient Protective Effect of B-Vitamins in Experimental Epilepsy in the Mouse Brain

Tamer Rabie, Wolfgang Mühlhofer, Thomas Bruckner, Anna Schwab, Alexander T Bauer, Manfred Zimmermann, Dieter Bonke, Hugo H Marti, Johannes Schenkel

Journal of Molecular Neuroscience (Springer) Germany , 24 September 2009

Neuroscience

Key words: Kainate administration, bcl-2 mrna expression, pyridoxine, kainate injection, tunel-positive cell, neuronal cell death, hippocampal ca3 region, genomic dna methylation, bcl-2 protein, dentate gyrus, follicular lymphoma, glutamate receptor, cognitive dysfunction, dead cell, saline-treated mouse

Results 3181 - 3190 of 3259
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