Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3259 papers published)

Results 3161 - 3170 of 3259
3161
418 Differences in radiation, cisplatin, and cetuximab sensitivity between subpopulations of head and neck cancer cells

C Nilsson, L La Fleur, K Roberg

European Journal of Cancer (Elsevier) , 28 June 2010

Oncology

3162
417 A c-Myc induced gene expression signature in human germinal center B cells predicts subtypes of aggressive non-Hodgkin Lymphoma

A Schrader, S Bentink, R Spang, D Lenze, M Hummel, M Kuo, P Murray, L Trümper, D Kube, M Vockerodt

European Journal of Cancer (Elsevier) , 28 June 2010

Oncology

3163
416 Characterization and quantification of macrophages in colorectal cancer by an automated cell system

R Rogojanu, I Mesteri, I Ellinger, T Talhammer, E Kallay, A Heindl, A Seewald, G Bises

European Journal of Cancer (Elsevier) Austria , 28 June 2010

Medical Image Analysis

3164
A Rat Model for Pressure Induced Deep Tissue Injury

Fang Lin, Mauli Modi, Briana Reprogle, Mike Bajema, Ziyan Wang, Gordon Kaskin, Mohsen Makhsous

ASME 2010 Summer Bioengineering Conference (ASME) USA , 16 June 2010

Biological Methods

Key words: Pressure, Biological tissues, Wounds

3165
An advanced approach for the characterization of dendritic cell-induced T cell proliferation in situ

Christian Florian, Thomas Barth, Anja K Wege, Daniela N Männel, Uwe Ritter

Immunobiology (Elsevier) Germany , 09 June 2010

Immunology

Key words: BrdU incorporation, fluorochromes, lymph node, proliferation, T cells, TissueQuest

3166
Neuropathologic and Biochemical Changes During Disease Progression in Liver X Receptor B_/_ Mice, A Model of Adult Neuron Disease

P Bigini, KR Steffensen, A Ferrario, L Diomede

Journal of Neuropathology and Experimental Neurology (American Association of Neuropathologists) USA , 01 June 2010

Neuroscience

Key words: Amytrophic lateral sclerosis, Cholesterol, CNS Inflammation, Glial cells, Liver X receptors, Motor neurons, Spinal neurons

Pathological State: Amyotrophic lateral sclerosis

3167
Neuropathologic and Biochemical Changes During Disease Progression in Liver X Receptor β−/− Mice, A Model of Adult Neuron Disease

Paolo Bigini, Knut R Steffensen, Anna Ferrario, Luisa Diomede, Giovanni Ferrara, Sara Barbera, Sonia Salzano, Elena Fumagalli, Pietro Ghezzi, Tiziana Mennini, Jan-Åke Gustafsson

Journal of Neuropathology and Experimental Neurology (Oxford University Press) USA , 01 June 2010

Neuroscience

Key words: Amyotrophic lateral sclerosis, Cholesterol, CNS inflammation, Glial cells, Liver X receptors, Motor neurons, Spinal neurons

Pathological State: Amyotrophic lateral sclerosis

3168
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg, Robert Hamanaka, William W Wheaton, Samuel Weinberg, Joy Joseph, Marcos Lopez, Balaraman Kalyanaraman, Gökhan M Mutlu, G R Scott Budinger, Navdeep S Chandel

PNAS (PNAS) USA , 11 May 2010

Oncology

Key words: Warburg Effect glutamine glycolysis lung cancer complex III

3169
Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

Benelita Tina Elie, Vasilena Gocheva, Tanaya Shree, Stacie A Dalrymple, Leslie J Holsinger, Johanna A Joyce

Biochimie (Elsevier) USA , 04 May 2010

Oncology

Key words: Cancer, Cysteine cathepsin, Protease, Therapy

3170
Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

Prakash G Chandak, Branislav Radovic, Elma Aflaki, Dagmar Kolb, Marlene Buchebner, Eleonore Fröhlich, Christoph Magnes, Frank Sinner, Guenter Haemmerle, Rudolf Zechner, Ira Taba, Sanja Levak-Fran, Dagmar Kratky

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Austria, USA , 27 April 2010

Cell Biology

Key words: ATP, Fatty Acid, Metabolism Glucose Lipase Lipid, Droplet Macrophage, Phagocytosis, Triacylglycerol

Results 3161 - 3170 of 3259
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