Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 3031 - 3040 of 3293
3031
Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes

Y Dombrowski, M Peric, S Koglin, N Kaymakanov, V Schmezer, M Reinholz, T Ruzicka andJ Schauber

Allergy (Wiley) Germany , 13 September 2012

Allergy Research

Key words: AIM2 inflammasome, allergic reaction, cytosolic DNA, honey bee venom, keratinocytes

Organism: Human

Cell Line: Epidermal keratinocytes

3032
Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis

Doris Maria Hummel, Ursula Thiem, Julia Höbaus, Ildiko Mesteri, Lukas Gober, Caroline Stremnitzer, João Graça, Barbara Obermayer-Pietsch, Enikö Kallay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, UK , 11 September 2012

Oncology

Key words: Vitamin D, colorectal cancer, dysplasia, chemoprevention, cyp24a1, cyp27b1

Organism: Mouse

Tissue: Colon

3033
Quantitative Immunofluorescence Reveals the Signature of Active B-cell Receptor Signaling in Diffuse Large B-cell Lymphoma

Agata M Bogusz, Richard HG Baxter, Treeve Currie, Papiya Sinha, Aliyah R Sohani, Jeffery L Kutok, Scott J Rodig

Clinical Cancer Research (AACR Publications) USA , 10 September 2012

Oncology

Key words: B-cell receptor, diffuse large B-cell lymphomas, DLBCL pathogenesis

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

3034
Isolation and phenotypic characterisation of stem cells from late stage osteoarthritic mesenchymal tissues

Labusca, Luminita, Zugun-Eloae, Florin, Shaw, Georgina, Botez, Paul, Barry, Frank, Mashayekhi, Kaveh

Current stem cell research and Therapy (Ingentaconnect) Romania , 01 September 2012

Stem Cell Research

Key words: Chondrogenesis, mesenchymal stem cells, osteoarthritis, regenerative medicine.

Organism: Human

Tissue: Bone, Adipose Tissue

Pathological State: Osteoarthritis

3035
The use of a tumor metastasis targeting peptide to deliver doxorubicin-containing liposomes to highly metastatic cancer

Zhaohui Wang, Yang Yu, Wenbing Dai, Jingkai Lu, Jingrong Cui, Hounan Wu, Lan Yuan, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang

Biomaterials (Elsevier) China , 30 August 2012

Nanomedicine

Key words: Highly metastatic tumor, targeting, nanomedicine, liposomes, delivery

Organism: Mouse

Tissue: Breast, Xenograft Tumor

Pathological State: Cancer

3036
Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

NS Prolyl, H Domain

Stroke (AHA Journals) Germany , 28 August 2012

Neuroscience

Key words: HIF-1, hypoxia, neuroprotection, PHD, stroke

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

3037
Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205

Martin Puhr, Julia Hoefer, Georg Schäfer, Holger HH Erb, Su Jung Oh, Helmut Klocker, Isabel Heidegger, Hannes Neuwirt, Zoran Culig

The American Journal of Pathology (Elsevier) China , 11 August 2012

Oncology

Key words: Docetaxel, (miR)-200c, miR-205, E-cadherin, Systemic polychemotherapy

Organism: Human

Tissue: Prostate

Pathological State: Cancer

3038
Quantitative and phenotypic analysis of mesenchymal stromal cell graft survival and recognition by microglia and astrocytes in mouse brain

Nathalie De Vocht,Dan Lin, Jelle Praet, Chloé Hoornaert, Kristien Reekmans, Debbie Le Blon, Jasmijn Daans, Patrick Pauwels, Herman Goossens, Niel Hens, Zwi Berneman, Annemie Van der Linden, Peter Ponsaert

Immunobiology (Elsevier) Belgium , 09 August 2012

Immunology

Key words: Astrocytes, brain, cell transplantation, mesenchymal stromal cell, microglia

Organism: Mouse

Tissue: Brain

3039
A mouse model to identify cooperating signaling pathways in cancer

Monica Musteanu, Leander Blaas, Rainer Zenz, Jasmin Svinka, Thomas Hoffmann, Beatrice Grabner, Daniel Schramek, Hans-Peter Kantner, Mathias Müller, Thomas Kolbe, Thomas Rülicke, Richard Moriggl, Lukas Kenner, Dagmar Stoiber, Josef Martin Penninger, Helmut Popper, Emilio Casanova and Robert Eferl

Nature Methods (Nature) Austria, Spain , 05 August 2012

Oncology

Key words: animal disease models, Cancer genetics, Mouse

Organism: Mouse

Tissue: Lung, Pancreas, Skin

Pathological State: Cancer

3040
Activation of Notch Signaling During Ex Vivo Expansion Maintains Donor Muscle Cell Engraftment

Maura H Parker, Carol Loretz, Ashlee E Tyler, William J Duddy, John K Hall, Bradley B Olwin, Irwin D Bernstein, Rainer Storb, Stephen J Tapscott

Stem Cells (Wiley) USA , 03 August 2012

Stem Cell Research

Key words: Striated muscle, satellite cells, regeneration, primary cell culture, notch ligand, cell transplantation

Organism: Mouse

Tissue: Muscle

Results 3031 - 3040 of 3293
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