Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 3011 - 3020 of 3293
3011
The in Vivo Imaging Platform for Cell Tracking in the Stem Cell-Induced Immune Tolerance to Vascularized Composite Allotransplantation: 1756

CJ Wen, HY Cheng, LY Shih, CF Lin, FC Wei

Transplantation (Wolters Kluwer) China , 27 November 2012

Microscopy

Organism: Rat

Tissue: Whole Organism

Pathological State: Allogeneic Transplantation

3012
Proteinuria triggers renal lymphangiogenesis prior to the development of interstitial fibrosis

Saleh Yazdani, Fariba Poosti, Andrea B Kramer, Katarina Mirković, Arjan J Kwakernaak, Menno Hovingh, Maartje C J Slagman, Klaas A Sjollema, Martin H de Borst, Gerjan Navis, Harry van Goor, Jacob van den Born

PLoS One (PLOS) The Netherlands , 26 November 2012

Nephrology

Key words: Lymph, Proteinuria, Kidneys, Fibrosis, Macrophages, Fibroblasts, Epithelial cells, Collagens

Organism: Rat

Tissue: Kidney

Pathological State: Renal Fibrosis

3013
Higher thymocyte selection-associated high mobility group box (TOX) expression predicts poor prognosis in patients with ovarian cancer

S Li, S Yang, Y Hong

BMC cancer (BMC) China , 25 November 2012

Oncology

Key words: Ovarian cancer, TOX, CD8 + T cell, Prognosis

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

3014
Epithelial Cell Adhesion Molecule Regulates Tumor Initiation and Tumorigenesis via Activating Reprogramming Factors and Epithelial-Mesenchymal Transition Gene Expression in Colon Cancer

Cheng-Wei Lin, Mei-Yin Liao, Wen-Wei Lin, Yi-Ping Wang, Tung-Yin Lu, Han-Chung Wu

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Taiwan , 16 November 2012

Oncology

Key words: Cancer Biology, Cancer Stem Cells, Cancer Tumor, Promoter Oncogene, Stem Cells EpCAM, Epithelial-Mesenchymal Transition, Reprogramming Factor Tumor-initiating, Cells Tumorsphere

Organism: Human

Tissue: Colon

Pathological State: Cancer

3015
Photodynamic Control of Bioactivity in a Nanofiber Matrix

Shantanu Sur, John B Matson, Matthew J Webber, Christina J Newcomb, Samuel I Stupp

ACS NANO (ACS Publications) USA , 15 November 2012

Nanomedicine

Key words: Supramolecular nanofibers, cell morphological analysis, nitrobenzyl, projected cell area, photodegradable, RGDS epitope

Organism: Mouse

Cell Line: NIH 3T3 mouse embryonic fibroblasts

3016
Valproic Acid Induces Cutaneous Wound Healing In Vivo and Enhances Keratinocyte Motility

Soung-Hoon Lee, Muhammad Zahoor, Jae-Kwan Hwang, Do Sik Min, Kang-Yell Choi

PLoS One (PLOS) South Korea , 07 November 2012

Dermatology

Key words: Wound healing, keratinocytes, collagens, keratins, ERK signaling cascade, Wnt signaling cascade, immunohistochemical analysis, beta-catenin signaling

Organism: Mouse

Tissue: Skin

Pathological State: Cutaneous wound

3017
SOCS-3 is downregulated in progressive CKD patients and regulates proliferation in human renal proximal tubule cells in a STAT1/3 independent manner

H Neuwirt, IE Eder, M Puhr, M Rudnicki

Laboratory Investigation (Nature) Austria , 29 October 2012

Physiology

Key words: Cell proliferation, Cell signalling, Chronic kidney disease

Organism: Human

Tissue: Kidney

Pathological State: Kidney Disease

3018
Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells

Ji Hyeon Ju, Yu-Jung Heo, Mi-La Cho, Joo-Yeon Jhun, Jin-Sil Park, Seon-Yeong Lee, Hye-Jwa Oh, Su-Jin Moon, Seung-Ki Kwok, Kyung-Su Park, Sung-Hwan Park, Ho-Youn Kim

Arthritis & Rheumatology (Wiley) South Korea , 27 October 2012

Rheumatology

Key words: STAT-3–mediated regulation, rheumatoid arthritis, CD4+ T cells, synovial fluid

Organism: Human

Pathological State: Rheumatoid Arthritis

Cell Line: PBMCs

3019
Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds

Sungsoo S Lee, Brian J Huang, Stuart R Kaltz, Shantanu Sur, Christina J Newcomb, Stuart R Stock, Ramille N Shah, Samuel I Stupp

Biomaterials (Elsevier) USA , 22 October 2012

Regenerative Medicine

Key words: Peptide amphiphile, heparin, heparan sulfate, BMP-2 (bone morphogenetic protein-2), regenerative medicine, bone regeneration

Organism: Rat

Tissue: Bone

3020
Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice

Krisztina Szalai, Tamara Kopp, Anna Lukschal, Caroline Stremnitzer, Julia Wallmann, Philipp Starkl, Luc Vander Elst, Jean-Marie Saint-Remy, Isabella Pali-Schöll, Erika Jensen-Jarolim

Experimental Dermatology (Wiley) Austria, Belgium , 15 October 2012

Dermatology

Key words: Allergic eczema, atopic eczema, Der p1 and Der p 2, house dust mite, protease activity, recombinant allergens

Organism: Mouse

Tissue: Skin

Pathological State: Eczema

Results 3011 - 3020 of 3293
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