Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 2981 - 2990 of 3293
2981
Late Infusion of Cloned Marrow Fibroblasts Stimulates Endogenous Recovery from Radiation-Induced Lung Injury

Mineo Iwata, David K Madtes, Kraig Abrams, Wayne J E Lamm, Robb W Glenny, Richard A Nash, Aravind Ramakrishnan, Beverly Torok-Storb

PLoS One (PLOS) USA , 08 March 2013

Regenerative Medicine

Key words: Dogs, pulmonary imaging, computed axial tomography, stem cells, fibroblasts, endothelial cells, pulmonary function, reverse transcriptase-polymerase chain reaction

Organism: Dog

Tissue: Lung

Pathological State: Radiation-induced lung injury

2982
Quantitative measurement of the androgen receptor in prepuces of boys with and without hypospadias

Renate Pichler, Gabriel Djedovic, Helmut Klocker, Isabel Heidegger, Alexander Strasak, Wolfgang Loidl, Jasmin Bektic, Viktor Skradski, Wolfgang Horninger, Josef Oswald

BJU International (Wiley) Austria , 07 March 2013

Endocrinology

Key words: Hypospadias, aetiology, androgen receptor, genetics, signalling

Organism: Human

Tissue: Prostate

Pathological State: Hypospadias

2983
FRI0270 Development of systemic lupus-like disease in regulatory T cells (TREG)-deficient scurfy mice

G Stummvoll, X Wei, H Leiss, B Niederreiter, B Heckmann, W Ulrich, A Enk, J Smolen, E Hadaschik

Annals of the Rheumatic Diseases (BMJ Journals) Austria, Germany , 01 March 2013

Rheumatology

Key words: Lupus, T cells

Organism: Mouse

Tissue: Skin

Pathological State: Lupus

2984
The 10th International Congress on SLE

McMahon M, Skaggs B, Grossman J, Sahakian L, FitzGerald J, Lourenco E, Ragavendra N, Charles-Schoeman C, Gorn A, Karpuzas G, Taylor M, Watson K, Weisman M, Wallace D, Hahn BH

Lupus (SAGE Journals) USA , 01 March 2013

Rheumatology

Key words: Pro-inflammatory HDL, subclinical atherosclerosis, NGAL (lipocalin-2)

2985
Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction

CH Chen, SS Wang, EIH Wei, TY Chu, PCH Hsieh

Molecular Therapy (Cell Press) Taiwan , 01 March 2013

Cardiology

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Infarction

2986
Human Umbilical Vein Endothelial Cells Protect Against Hypoxic-Ischemic Damage in Neonatal Brain via Stromal Cell-derived Factor 1/C-X-C Chemokine Receptor Type 4

Chia-Ching Wu, Yi-Chi Chen, Ying-Chao Chang, Lan-Wan Wang, Yung-Chieh Lin, Yi-Lun Chiang, Chien-Jung Ho, Chao-Ching Huang

Stroke (AHA Journals) Taiwan , 28 February 2013

Neuroscience

Key words: Human umbilical vein endothelial cell, neonatal brain, neurovascular unit, SDF-1/CXCR4

Organism: Rat, Human

Tissue: Brain

Pathological State: Cerebral ischemia

Cell Line: HUVECs (Human umbilical vein endothelial cells)

2987
Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound

Po-Hung Hsu, Kuo-Chen Wei, Chiung-Yin Huang, Chih-Jen Wen, Tzu-Chen Yen, Chao-Lin Liu, Ya-Tin Lin, Jin-Chung Chen, Chia-Rui Shen, Hao-Li Liu

PLoS One (PLOS) Taiwan , 27 February 2013

Nanomedicine

Key words: Viral vectors, magnetic resonance imaging, central nervous system, astrocytes, gene delivery, gene expression, acoustics, neurons

Organism: Mouse

Tissue: Brain

2988
Abatacept (CTLA-4IG) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis

M Bonelli, E Ferner, L Göschl, S Blüml, A Hladik, T Karonitsch, H P Kiener, R Byrne, B Niederreiter, C W Steiner, E Rath, M Bergmann, J S Smolen, C Scheinecker

Arthritis & Rheumatology (Wiley) Austria , 25 February 2013

Rheumatology

Key words: Antigen-presenting cells, CTLA-4Ig, Peripheral blood mononuclear cells

Organism: Human

Pathological State: Rheumatoid Arthritis

Cell Line: PBMCs

2989
Tumor necrosis factor–inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor–driven model of rheumatoid arthritis

Nikolaus B Binder, Antonia Puchner, Birgit Niederreiter, Silvia Hayer, Harald Leiss, Stephan Blüml, Roman Kreindl, Josef S Smolen, Kurt Redlich

Arthritis & Rheumatology (Wiley) Austria, USA , 25 February 2013

Rheumatology

Key words: Tumor necrosis factor, osteoclastogenesis in vitro, cell–derived monocytes

Organism: Mouse

Tissue: Joint Tissue, Bone

Pathological State: Rheumatoid Arthritis

2990
Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2

Ewa Przybyt, Guido Krenning, Marja GL Brinker, Martin C Harmsen

Journal of Translational Medicine (Springer) The Netherlands , 13 February 2013

Cardiology

Key words: hl-1 cardiomyocyte, hl-1 cell, jak stat inhibitor, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation, cardiomyocyte proliferation

Organism: Human

Cell Line: Cardiomyocytes

Results 2981 - 2990 of 3293
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