Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 2971 - 2980 of 3293
2971
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer

Julia Höbaus, Doris M Hummel, Ursula Thiem, Irfete S Fetahu, Abhishek Aggarwal, Leonhard Müllauer, Gerwin Heller, Gerda Egger, Ildiko Mesteri, Sabina Baumgartner-Parzer, Enikö Kallay

International Journal of Cancer (Wiley) Austria , 05 April 2013

Oncology

Key words: CYP24A1, colorectal cancer, 20q13.2, methylation, proliferation

Organism: Human

Tissue: Colon

Pathological State: Cancer

2972
Transcatheter delivery of sorafenib-eluting polylactide-co-glycolide microspheres: therapy response studies in a rat model of hepatocellular carcinoma

J Chen, A Sheu, RJ Lewandowski, RA Omary, L Shea, AC Larson

Journal of Vascular and Interventional Radiology (Elsevier) USA , 02 April 2013

Oncology

Key words: Sorafenib, hepatocellular carcinoma, polylactide-co-glycolide

Organism: Rat

Tissue: Liver

Pathological State: Cancer

2973
Excisional Wound Healing Is Delayed in a Murine Model of Chronic Kidney Disease

Akhil K Seth, Mauricio De la Garza, Robert C Fang, Seok J Hong, Robert D Galiano

PLoS One (PLOS) USA , 25 March 2013

Nephrology

Key words: Chronic kidney disease, wound healing, kidneys, granulation tissue, angiogenesis, inflammation, renal failure, surgical and invasive medical procedures

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

2974
Effects of Cholic Acid and its Derivatives in Experimental Arthritis

Silvia Hayer, Emina Halilbasic, Birgit Niederreiter, Martin Willburger, Peter Mandl, Victoria Saferding, Stephan Blüml, Josef Smolen, Michael Trauner, Kurt Redlich

Annals of the Rheumatic Diseases (BMJ Journals) Austria , 20 March 2013

Rheumatology

Key words: Cholesterol metabolism, Collagen-induced arthritis, nor-ursodeoxycholic acid

Organism: Mouse

Tissue: Joint Tissue, Bone

Pathological State: Rheumatoid Arthritis

2975
Do High Molecular Weight Adiponectin Levels Associate with Radiographic Progression in early Rheumatoid Arthritis and Hand Osteoarthritis?

IR Klein-Wieringa, SN Andersen, JC Kwekkeboom, L Herb-vToorn, AHM van der Helm-van Mil, I Meulenbelt, TWJ Huizinga, M Kloppenburg, REM Toes, A Ioan-Facsinay

Annals of the Rheumatic Diseases (BMJ Journals) The Netherlands , 20 March 2013

Rheumatology

Key words: Adipokines, osteoarthritis, rheumatoid arthritis

Organism: Mouse

Tissue: Bone

Pathological State: Rheumatoid Arthritis

2976
The prognostic value of estrogen receptor beta and proline-, glutamic acid- and leucine-rich protein 1 (PELP1) expression in ovarian cancer

Stefanie Aust, Peter Horak, Dietmar Pils, Sophie Pils, Christoph Grimm, Reinhard Horvat, Dan Tong, Bernd Schmid, Paul Speiser, Alexander Reinthaller, Stephan Polterauer

BMC Cancer (Springer) Austria , 14 March 2013

Oncology

Key words: Mucinous ovarian cancer, residual tumor load, mucinous eoc, eoc tissue, serous eoc, clear cell carcinoma, endometrioid tumor, breast cancer tissue, cytoreductive surgery, human eoc, endometrial cancer, serum ca-125, paraaortic lymphadenectomy, undifferentiated carcinoma, surgical staging

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

2977
PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer

Mohammad W Khan, Ali Keshavarzian, Elias Gounaris, Joshua E Melson, Eric C Cheon, Nichole R Blatner, Zongmin E Chen, Fu-Nien Tsai, Goo Lee, Hyunji Ryu, Terrence A Barrett, David J Bentrem, Philipp Beckhove, Khashayarsha Khazaie

Clinical Cancer Research (AACR Publications) USA, Germany , 13 March 2013

Oncology

Key words: Colitis, dysplasia, colorectal cancer, colonic submucosa, phosphoinositide 3-kinase

Organism: Human

Tissue: Colon

Pathological State: Colitis, Cancer

2978
Tumor STAT1 Transcription Factor Activity Enhances Breast Tumor Growth and Immune Suppression Mediated by Myeloid-derived Suppressor Cells

Laura M Hix, John Karavitis, Mohammad W Khan, Yihui H Shi, Khashayarsha Khazaie, Ming Zhang

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) USA , 13 March 2013

Oncology

Key words: Breast Cancer, immunosuppression, signal transduction, T Cell, tumor immunology, MDSC, STAT1, mouse model of breast cancer

Organism: Human, Mouse

Tissue: Breast

Pathological State: Cancer

2979
Type III Secretion of ExoU Is Critical during Early Pseudomonas aeruginosa Pneumonia

Heather A Howell, Latania K Logan, Alan R Hauser

mBio (ASM) USA , 12 March 2013

Pulmonology

Key words: Eukaryotic cells, Many Gram-negative bacteria, Pseudomonas aeruginosa

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia, Pseudomonas Infection

2980
Rapid dramatic alterations to the tumor microstructure in pancreatic cancer following irreversible electroporation ablation

Zhuoli Zhang, Weiguo Li, Daniel Procissi, Patrick Tyler, Reed A Omary, Andrew C Larson

Nanomedicine (Future Medicine) USA , 12 March 2013

Nanomedicine

Key words: Immunohistochemistry apoptosis, IRE-treated tumors

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

Results 2971 - 2980 of 3293
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