Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3293 papers published)

Results 2951 - 2960 of 3293
2951
In vivo bioluminescence reporter gene imaging for the activation of neuronal differentiation induced by the neuronal activator neurogenin 1 (Ngn1) in neuronal precursor cells

Hyun Jeong Oh, Do Won Hwang, Hyewon Youn, Dong Soo Lee

European Journal of Nuclear Medicine and Molecular Imaging (Springer) South Korea , 11 June 2013

Neuroscience

Key words: Reporter gene imaging, vector complex, neuronal differentiation, neuronal marker map2, gaussia luciferase, stem cell therapy, human nsc, pluripotent stem cell, grafted stem cell, neural precursor cell, hela cell, neurite outgrowth, nucleic acid delivery, nude mouse, luciferase signal

Organism: Human

Cell Line: F11 cells

2952
SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas

Linfeng Chen, Stefano Monti,Przemyslaw Juszczynski, Jing Ouyang, Bjoern Chapuy, Donna Neuberg, John G Doench, Agata M Bogusz,Thomas M Habermann, Ahmet Dogan, Thomas E Witzig, Jeffery L Kutok, Scott J Rodig, Todd Golub, Margaret A Shipp

Cancer Cell (Cell Press) USA , 10 June 2013

Oncology

Key words: B cell receptor, diffuse large B cell lymphoma

Organism: Human

Pathological State: Cancer

Cell Line: DLBCL cells

2953
Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4

Prabakaran Nagarajan, Zhongqi Ge, Bianca Sirbu, Cheryl Doughty, Paula A Agudelo Garcia, Michaela Schlederer, Anthony T Annunziato, David Cortez, Lukas Kenner, Mark R Parthun

PLoS Genetics (PLOS) USA, Austria , 06 June 2013

Genetics

Key words: Histones, Acetylation, Chromatin, Lysine, DNA damage, Mouse models, DNA replication, Neonates

Organism: Mouse

Tissue: Whole Organism

2954
Clinical significance and evolution of hepatic HBsAg expression in HBeAg-positive patients receiving interferon therapy

Tung-Hung Su, Chun-Jen Liu, Hung-Chih Yang, Yung-Ming Jeng, Huei-Ru Cheng, Chen-Hua Liu, Tai-Chung Tseng, Thai-Yen Ling, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao

Journal of Gastroenterology (Springer) Taiwan , 05 June 2013

Gastroenterology

Key words: Hbsag decline, hbsag expression, on-treatment hbsag, hbsag titer, hbsag clearance, serum hbsag, hbeag loss, hbeag-negative chb, hbv genotype, hbv dna, serum hbv-dna, hbeag-positive chb, hbsag quantification, architect hbsag, viral load

Organism: Human

Tissue: Liver

Pathological State: Hepatitis B Virus Infection

2955
Quantitative Evaluation of Stem Cell Grafting in the Central Nervous System of Mice by In Vivo Bioluminescence Imaging and Postmortem Multicolor Histological Analysis

Kristien Reekmans, Nathalie De Vocht, Jelle Praet, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Annemie Van der Linden, Zwi Berneman, Peter Ponsaerts

Imaging and Tracking Stem Cells (Springer) Belgium , 04 June 2013

Stem Cell Research

Key words: Neural stem cells, mesenchymal stromal cells eGFP, luciferase, cell transplantation, brain, bioluminescence imaging, histology, microglia, astrocytes

2956
Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type iα of protein kinase a in vivo

Iris E Eder, Martina Egger, Hannes Neuwirt, Christof Seifarth, Danilo Maddalo, Andreas Desiniotis, Georg Schäfer, Martin Puhr, Jasmin Bektic, Andrew C B Cato and Helmut Klocker

International Journal of Molecular Sciences (MDPI) Austria, Germany , 04 June 2013

Oncology

Key words: androgen receptor, cAMP-dependent protein kinase A, regulatory subunit type Iα, prostate cancer, antisense molecules, dual targeting, LNCaP xenografts, castration resistance

Organism: Mouse

Tissue: Prostate, Xenograft Tumor

Pathological State: Cancer

2957
Smooth muscle cell transplantation improves bladder contractile function in streptozocin-induced diabetic rats

Chaitanya Gopinath, Peter Ponsaerts, Erik Fransen, Nele Boeykens, Patrick Pauwels, Jean-Jacques Wyndaele

Cytotherapy (Elsevier) Belgium , 01 June 2013

Transplantation Medicine

Key words: Bladder smooth muscle cells, cell graft survival, cell transplantation, contractile function, diabetes, in vivo cystometry

Organism: Rat

Tissue: Bladder

Pathological State: Diabetes

2958
Biocompatible fluorescent nanoparticles for in vivo stem cell tracking

Lidia Cova, Paolo Bigini, Valentina Diana, Leopoldo Sitia, Raffaele Ferrari, Ruggiero Maria Pesce, Rushd Khalaf, Patrizia Bossolasco, Paolo Ubezio, Monica Lupi, Massimo Tortarolo, Laura Colombo, Daniela Giardino, Vincenzo Silani, Massimo Morbidelli, Mario Salmona and Davide Moscatelli

Nanotechnology (IOP Science) Italy, Switzerland , 20 May 2013

Nanomedicine

Key words: fluorescent nanoparticles, in vivo stem cell tracking, hAFCs, methyl methacrylate (MMA)

Organism: Human

Cell Line: hAFC cells

2959
Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents

An Ning Cheng, Shih Sheng Jiang,Chi-Chen Fan, Yu-Kang Lo, Chan-Yen Kuo, Chung-Hsing Chen, Ying-Lan Liu, Chun-Chung Lee, Wei-Shone Chen, Tze-Sing Huang, Tao-Yeuan Wang, Alan Yueh-Luen Lee

Cancer Letters (Elsevier) Taiwan , 16 May 2013

Oncology

Key words: Cdc7, oral cancer, prognostic marker, chemotherapy resistance

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

2960
Identification and Characterization of Poorly Differentiated Invasive Carcinomas in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis

Karen E Hunter, Marsha L Quick, Anguraj Sadanandam,Douglas Hanahan, Johanna A Joyce

PLoS One (PLOS) USA, Switzerland , 14 May 2013

Oncology

Key words: Insulin, differentiated tumors, invasive tumors, cell staining, insulinoma, immunofluorescence staining, carcinomas, cell differentiation

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

Results 2951 - 2960 of 3293
conact bus
WANT TO KNOW MORE?
CONTACT US »
Blog update spatial
BLOG UPDATE
An Introduction to Spatial Tissue Cytometry

Cytometry encompasses several methods for investigating cells, such as their count, cell cycle state, phenotype, morphology, size ...

NEWS
NEW Boxed Cytometer - Colubris

We have a lot of exciting plans to share for our big birthday, but we also have many important milestones to reflect on and remember...

Festival Hacks
Subscribe to our scientific Infoletter
Subscribe to Newsletter
App Showcase
APP SHOWCASE
IHC IMMUNE SATUS IN SITU

The IHC Immune Status in Situ App uses the AI classifier to segment tissue into morphological entities such as tumor, stroma, and lymphocyte clusters. It further identifies single cells ...

Publications
TOOLS
Reference Publications

Explore our online database of reference publications to find tout how tissue cytometry can elevate your research

Appcenter
TOOLS
StrataQuest Appcenter

Explore our vast catalog of analysis solutions in our Strataquest Appcenter and get inspired by the variety of applications.

Nadine Bayer
TG ACADEMY WEBINAR
The Effect of Stem Cell Transplantation on Skin Microorganisms
Watch Webinar
Nadine Bayer, PhD
Medical University
of Vienna
Eurolab Article
ARTICLE
Spatial Tissue Cytometry: Success Stories - Eurolab Article

Read about tissue cytometry's potential in understanding the complexities of cell populations in the tissue environment

previous arrow
next arrow

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

Keep in Touch

Be the first to hear about the latest scientific updates



We use cookies

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies).
You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.

Ok Decline
More information