Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3219 papers published)

Results 21 - 30 of 3219
21
Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma

WT Kuo, YC Lee, JB Liao, CJ Tseng, YF Yang

Discover Oncology (Springer) Taiwan , 07 February 2025

Oncology

Key words: Sulfatases, SUMF2, FBXW7, Urothelial carcinoma

Organism: Human

Tissue: Bladder

Pathological State: Cancer

22
Caspase Inhibition Restores Collagen I α1 and Fibronectin Release in Cigarette Smoke Extract-Exposed Human Lung Fibroblasts

AL Mensa, M Buscetta, RR Woldhuis, M Cimino, MR Giuffrè, M Cristaldi, P Dino, L Fiore, A Fucarino, GL Iacono, A Bertani, CA Brandsma, F Bucchieri, C Cipollina

American Journal of Physiology Lung Cellular and Molecular Physiology (American Physiological Society) Italy, The Netherlands , 06 February 2025

Pulmonology

Key words: caspase; cigarette smoke extract; extracellular matrix; gasdermin E; human lung fibroblasts

Organism: Human

Tissue: Lung

Pathological State: Smoking

23
High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT)

Y Ding, Y Feng, Y Ye, J Shen, C Guo, X He, L Zhu, L Wang

Frontiers in Oncolgoy (Frontiersin) China, Taiwan, Brazil , 06 February 2025

Oncology

Key words: colorectal cancer, microsatellite-stable (MSS), low dose radiotherapy, tumor environment, immune checkpoint inhibitors

Organism: Human

Tissue: Liver

Pathological State: Cancer

24
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle

H Dong, Y Lyu, CY Huang, SY Tsai

Autophagy (Taylor & Francis) Singapore , 06 February 2025

Microbiology

Key words: Autophagy, immunoproteasome, proteasome, protein quality control, skeletal muscle, translation

Organism: Mouse

Tissue: Muscle

Pathological State: Muscle Deficiency

25
Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy

Y Yao, C Chen, B Li, W Gao

Cancer Immunology, Immunotherapy (Springer) China , 04 February 2025

Oncology

Key words: HVEM, NSCLC, Jurkat cells, Immunotherapy

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

26
Patient-Derived Cancer-Associated Fibroblasts Support the Colonization of Tumor Cells in Head and Neck Squamous Cell Carcinoma

J Federspiel, TB Steinbichler, SM Vorbach, MT Eling, W Borena, C Seifarth, BG Hofnauer, J Dudas

Biomedicines (MDPI) Austria , 04 February 2025

Oncology

Key words: patient-derived cell culture; cancer-associated fibroblasts (CAFs); head and neck squamous cell carcinoma (HNSCC); irradiation; tumor cell relapse

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

27
Morphometry of the Scapular Notch and Its Clinical Implication in Suprascapular Nerve Entrapment

J Duque-Colorado, OA Alzate-Mejia, M del Sol

Diagnostics (MDPI) Chile, Colombia , 02 February 2025

Osteology

Key words: advanced anatomy; morphometry; scapula; scapular notch; neuropathy; suprascapular nerve

Organism: Human

Tissue: Nerve

Pathological State: Entrapment Neuropathy

28
Purple Sweet Potato Ameliorates High-Fat Diet-Induced Visceral Adiposity by Attenuating Inflammation and Promoting Adipocyte Browning

CH Yen, MH Chiang, YC Lee, ES Kao, HJ Lee

Journal of Agricultural and Food Chemistry (ACS Publications) Taiwan , 02 February 2025

Nutritional science

Key words: high-fat diet, adiposity, visceral fat, inflammasome, adipocyte browning, purple sweet potato

Organism: Rat

Tissue: Heart

Pathological State: Adiposity

29
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

L Ye, S Shen, Q Mao, H Lu, H Liu, P Zhang, Z Jiang, W Ma, Y Sun, Y Chu, Z Zhou, R Liu, J Li, ST Li, P Gao, H Zhang

Cell Reports (Cell) China , 31 January 2025

Oncology

Key words: hepatocellular carcinoma, post-translational modification, histone methylation

Organism: Human

Tissue: Liver

Pathological State: Cancer

30
VPS18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis–infected macrophages

C Jani, N Jain, AK Marsh, P Uchil, T Doan, M Hudspith, OT Glover, ZR Baskir, J Boucau, DE Root, NN van der Wel, JG Doench, AK Barczak

Science Advances (Science) USA, The Netherlands , 31 January 2025

Bacteriology

Organism: Human

Pathological State: Bacterial Infection

Cell Line: THP-1

Results 21 - 30 of 3219
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