Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 1791 - 1800 of 3293
1791
Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity

SH Park, J Kim, Y Moon

Communications Biology (Nature) South Korea , 27 May 2020

Gastroenterology

Key words: Biomarkers, Cell Biology, Chemokines, Inflammation, Signal Transduction

Organism: Mouse

Tissue: Intestine

1792
Interaction of different cell types with magnesium modified by plasma electrolytic oxidation

M Echeverry-Rendon, F Echeverria, MC Harmsen

Colloids and Surfaces B: Biointerfaces (Elsevier) Colombia, The Netherlands , 26 May 2020

Biomaterials

Key words: Magnesium, PEO, Adipose-Derived Stromal, ASC, Differentiation, Cytotoxicity

Organism: Human

Cell Line: HUVECs, ACSs

1793
Absence of α-calcitonin gene-related peptide modulates bone remodeling properties of murine osteoblasts and osteoclasts in an age-dependent way

T Niedermair, S Schirner, RH Straub, S Grässel

Mechanisms of Ageing and  Development (Elsevier) Germany , 22 May 2020

Osteology

Key words: Bone, Osteoblast, Osteoclast, α -Calcitonin Gene-Related Peptide (α -CGRP), Osteopenia

Organism: Mouse

Tissue: Bone

1794
KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation

RAF Gjaltema, D Goubert, C Huisman, C del Pilar Garcia Tobilla, M Koncz, PG Jellema, D Wu, U Brouwer, A Kiss, PJ Verschure, RA Bank, MG Rots

International Journal of Molecular Sciences (MDPI) The Netherlands, Hungary , 21 May 2020

Oncology

Key words: Pigenetic Editing, KRAB, Gene Repression, PLOD2, Fibrosis, Cancer

Organism: Human

Cell Line: Human skin fibroblasts

1795
Synergistic effect of cell-derived extracellular matrix and topography on osteogenesis of mesenchymal stem cells

L Yang, L Ge, P van Rijn

ACS Applied Materials & Interfaces (ACS Publications) The Netherlands , 18 May 2020

Tissue Engineering

Key words: Extracellular Matrix, Topography, Mesenchymal Stem Cells, Osteogenic Differentiation, Mechanotransduction

Organism: Human

Cell Line: hBM-MSCs

1796
Biomimetic Multiscale Hierarchical Topography Enhances Osteogenic Differentiation of Human Mesenchymal Stem Cells

L Yang, L Ge, Q Zhou, T Mokabber, Y Pei, R Bron, P van Rijn

Advanced Materials Interfaces (Wiley) The Netherlands, China , 13 May 2020

Stem Cell Research

Key words: Collagen, Extracellular Matrix, Hierarchical Topography, Human Mesenchymal Stem Cells, Mechanotransduction, Osteogenic Differentiation

Organism: Human

Cell Line:  hBM‐MSCs

1797
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Kim L Brunekreeft, Sterre T Paijens, Maartje CA Wouters, Fenne L Komdeur, Florine A Eggink, Joyce M Lubbers, Hagma H Workel, Elisabeth C Van Der Slikke, Noor EJ Pröpper, Ninke Leffers, Julien Adam, Harry Pijper, Annechien Plat, Arjan Kol, Hans W Nijman, Marco De Bruyn

OncoImmunology (Taylor & Francis) The Netherlands, France, Canada , 13 May 2020

Oncology, Immunology

Key words: Epithelial Ovarian Cancer, Chemotherapy, Tumor Microenvironment, Cancer Immunology, MHC-I

Organism: Human

Tissue: Ovaries, Lymphoid Tissue

Pathological State: Cancer

1798
Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms

T Tachibana, A Kasajima, T Aoki, T Tabata, K McNamara, S Yazdani, S Satoko, F Fujishima, F Motoi, M Unno, H Sasano

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Japan, Germany , 11 May 2020

Endocrinology

Key words: Neuroendocrine Neoplasm, Insulinoma, Progesteron Receptor

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

1799
Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

M Granai, L Mundo, AU Akarca, MC Siciliano, H Rizvi, V Mancini, N Onyango, J Nyagol, NO Abinya, I Maha, S Margielewska, W Wi, M Bibas, PP Piccaluga, L Quintanilla-Martinez, F Fend, S Lazzi, L Leoncini, T Marafioti

Infectious Agents and Cancer (BMC) Italy, Germany, UK, Kenya, Egypt, , 06 May 2020

Oncology, Virology

Key words: Burkitt Lymphoma, Tumour Microenvironment, EBV, PD-L1, Immunotherapy, Immune Checkpoint

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

1800
Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach

L Yang, L Ge, Q Zhou, K Jurczak, P van Rijn

ACS Applied Bio Materials (ACS Publications) The Netherlands, China , 06 May 2020

Stem Cell Research

Organism: Human

Cell Line: hBM-MSCs

Results 1791 - 1800 of 3293
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