Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 1751 - 1760 of 3293
1751
Light‐emitting diode irradiation induces AKT/mTOR‐mediated apoptosis in human pancreatic cancer cells and xenograft mouse model

YM Kim, SH Ko, YI Shin, Y Kim, T Kim, J Jung, SY Lee, NG Kim, KJ Park, JH Ryu

Journal of Cellular Physiology (Wiley Online Library) South Korea , 04 August 2020

Oncology

Key words: AKT/mTOR Pathway, Apoptosis, LED Irradiation, Pancreatic Cancer, Tumor Growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1752
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

M Srivastava, Y Zhang, J Chen, D Sirohi, A Miller, Y Zhang, Z Chen, H Lu, J Xu, RJ Kuhn, WA Tao

Nature Communications (Nature) USA, China , 04 August 2020

Virology

Key words: Chemical Tools, Proteomics, Virus–Host Interactions

Organism: Human

Cell Line: HEK293T cells

1753
Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes

YJ Huang, TH Huang, VK Yadav, M Rachmawati Sumitra, DTW Tzeng, PL Wie, JW Shih, ATH Wu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, China , 01 August 2020

Oncology

Key words: Colon Cancer Stem Cells, Tumor Microenvironment, 5-FU Resistance, Tumorsphere Derived Exosomes, Β-Catenin/STAT3/MiR-1246 Signaling, Ovatodiolide

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1754
Endocrine-disrupting chemicals rapidly affect intercellular signaling in Leydig cells

A Yawer, E Sychrová, P Labohá, J Raška, T Jambor, P Babica, I Sovadinová

Toxicology and Applied Pharmacology (Elsevier) Czech Republic, Slovakia , 31 July 2020

Endocrinology

Key words: Connexins, Endocrine-Disrupting Chemicals, Gap Junctional Intercellular Communication, Leydig Cells, Reproductive Toxicants, Steroidogenesis

Organism: Mouse

Cell Line: Leydig TM3 cells

1755
A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model

IJ Su, HY Chang, HC Wang, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan , 30 July 2020

Neuroscience

Key words: Alzheimer's Disease Therapy, Curcumin Analog, TML-6, Aging, Bioavailability

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

1756
Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin

L Molcan, A Maier, A Zemančíková, K Gelles, J Török, M Zeman, I Ellinger

Cellular and Molecular Neurobiology (Springer) Slovakia, Austria , 30 July 2020

Cardiology

Key words: Rat Melatonin Receptor MT1, Melatonin, Mesenteric Artery (MA), Perivascular Fat Tissue (PVAT), Neurogenic Contraction

Organism: Rat

Tissue: Eye, Brain

1757
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy

J Ye, S Lu, M Wang, W Ge, H Liu, Y Qi, J Fu, Q Zhang, B Zhang, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China , 30 July 2020

Cardiology

Key words: Myocardial Ischemia Reperfusion Injury, Hydroxysafflor Yellow A, NLRP3, Autophagy, AMPK

Organism: Rat

Tissue: Heart

Pathological State: Myocardial Ischemia

1758
NHF-derived carbon dots: prevalidation approach in breast cancer treatment

CE Tiron, G Luta, M Butura, F Zugun-Eloae, CS Stan, A Coroaba, EL Ursu, G Dumitrita Stanciu, A Tiron

Scientific Reports (Nature) Romania , 29 July 2020

Oncology

Key words: Cancer, Drug Development, Medical Research, Oncology, Preclinical Research, Translational Research

Organism: Human

Cell Line: HUVECs and PASMCs

1759
BMI1-Mediated Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells Is Associated with Increased SP1 Activation and Cancer Stemness

HT Shen, PJ Chien, SH Chen, GT Sheu, MS Jan, BY Wang, WW Chang

Cancers (MDPI) Taiwan , 27 July 2020

Oncology

Key words: BMI1, SP1, Pemetrexed Resistance, Non Small Cell Lung Cancer, Cancer Stem Cells, Epithelial–Mesenchymal Transition

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

1760
A general method to optimize and functionalize red-shifted rhodamine dyes

JB Grimm, AN Tkachuk, L Xie, H Choi, B Mohar, N Falco, K Schaefer, R Patel, Q Zheng, Z Liu, J Lippincott-Schwartz, TA Brown, LD Lavis

Nature Methods (Nature) USA , 27 July 2020

Biological Methods

Key words: Chemical Biology, Chemical Tools, Fluorescence Imaging, Imaging

Organism: Mouse

Tissue: Brain

Results 1751 - 1760 of 3293
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