Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 1431 - 1440 of 3293
1431
Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews

RJ Ni, YM Shu, PH Luo, JN Zhou

Journal of Anatomy (Wiley) China , 12 October 2021

Reproductive Medicine

Organism: Tree Shrew

Tissue: Brain

1432
Changes in expressions of spermatogenic marker genes and spermatogenic cell population caused by stress

P Tian, Z Zhao, Y Fan, N Cui, B Shi, G Hao

Frontiers in Endocrinology (Frontiers Media S.A.) China , 11 October 2021

Reproductive Medicine

Key words: Stress, Testis, Spermatogenesis, Gene, RNA Sequencing

Organism: Rat

Tissue: Testis

1433
Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs

L Johnson Chacko, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudas, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fischer, A Zine

International Journal of Molecular Sciences (MDPI) USA, France, UK, Canada , 07 October 2021

Genetics

Key words: Human Induced Pluripotent Stem Cells, Otic Sensory Progenitors, Gene Expression Analysis, Extracellular Matrix, Integrins, Human Fetal Inner Ear

Organism: Human

Tissue: Bone

1434
Glucose/Glutathione Co-triggered Tumor Hypoxia Relief and Chemodynamic Therapy to Enhance Photothermal Therapy in Bladder Cancer

WH Chen, KJ Yu, JW Jhou, HH Pang, WH Wenig, WS Lin, HW Yang

ACS Applied Bio Materials (ACS Publications) Taiwan , 07 October 2021

Oncology, Pharmacology

Key words: Photothermal Therapy, Chemodynamic Therapy, Manganese Dioxide (MnO2), Tumor Hypoxia, Bladder Cancer

Organism: Mouse

Tissue: Bladder

Pathological State: Cancer

1435
Irreversible depletion of intestinal CD4+ T-cells is associated with T-cell activation during chronic HIV infection

OE Asowata, A Singh, A Ngoepe, N Herbert, R Faradoos, K Reddy, Y Zuingu, F Nene, N Mthabela, D Ramjit, K Govender, T Ndung'u, JZ Porterfield, JH Adamson, FG Madela, VT Manzini, F Anderson, A Leslie, HN Kløverpris

JCI Insight (American Society of Clinical Investigation) South Africa, Denmark, UK, Germany, USA , 07 October 2021

Immunology, Virology

Organism: Human

Tissue: Intestine

Pathological State: HIV Infection

1436
Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model

JT Yamaguchi, JA Weiner, S Minardi, AC Greene, DJ Ellenbogen, MJ Hallman, VP Shah, KM Weisz, S Jeong, T Nandurkar, C Yun, WK Hsu, EL Hsu

JOR Spine (Wiley) USA , 07 October 2021

Osteology

Organism: Mouse

Tissue: Bone

1437
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, L Haynes, S Yadav, T Tchkonia, GA Kuchei, JL Kirkland, M Xu

Nature Aging (Nature) USA, China , 07 October 2021

Aging

Key words: Ageing, Animal biotechnology, Senescence

1438
Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

H He, Q Liao, C Zhao, C Zhu, M Feng, Z Liu, L Jiang, L Zhang, X Ding, M Yuan, X Zhang, J Xu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China , 06 October 2021

Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

1439
Landscape of prognostic signatures and immunogenomics of the AXL/GAS6 axis in renal cell carcinoma

K Hakozaki, N Tanaka, K Takamatsu, R Takashi, Y Yasumizu, S Mikami, T Shinojima, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, R Mizuno, M Oya

British Journal of Cancer (Nature) Japan , 05 October 2021

Oncology

Key words: Renal Cell Carcinoma, Tumour Biomarkers

Organism: Human

Tissue: Kidney

Pathological State: Cancer

1440
NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression

J Liang, W Sun, H Song, C Wang, Q Li, C Li, D Wie, Y Zhao, C Li, H Zhang

Epigenomics (Future Medicine) China , 05 October 2021

Oncology, Pharmacology

Key words: Epithelial–Mesenchymal Transition, NOL6, Nucleolar Protein, Tumorigenesis, TWIST1

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

Results 1431 - 1440 of 3293
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