Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3293 papers published)

Results 11 - 20 of 3293
11
Can the co-localization of CD8+, PD-1, PD-L1 AND PD-L2 patterns provide guidance in clinical evolution of patients with head and neck cutaneous squamous cell carcinoma?

GN Bento, AB de Oliveira Santos, LL Matos, WC Faquin, SI Pai, CR Cernea

Brazilian Journal of Otorhinolaryngology (Elsevier) Brazil, USA , 24 May 2025

Oncology, Imaging

Key words: Cutaneous squamous cell carcinoma, Co-localization, PD-1, PD-L1, PD-L2

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

12
Single-Cell RNA Sequencing of the Primary Visual Cortex in Mice With Optic Nerve Injury

D Li, B Zou, Q Hu, X Zhang, W Zeng, L Liu, M Yu

Investigative Opthalmology & Visual Science (ARVO) China , 23 May 2025

Opthalmology

Key words: single-cell RNA sequencing (scRNA-seq), optic nerve injury, primary visual cortex, glial cell heterogeneity, PTGDS, CRYAB

Organism: Human

Tissue: Eye

Pathological State: Optic Nerve Injury

13
Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency

X Zhang, L Huang, C Li, J Yang, F Duan, Q Su, Y Zhang, M Kou, X Zhou, L Guo, S Chen, Y Niu, Z Li, S Ou, M Zhang, KKY Cheng, J Wu, X Xu, Q Lian

Cell Death Discovery (Nature) China , 22 May 2025

Pharmacology

Key words: Heart failure, Preclinical research

Organism: Mouse

Tissue: Heart

Pathological State: Cardiac Dysfunction

14
Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors

J Guan, G Hong, Z Liu, Y Zheng, J He…

Investigative Opthalmology & Visual Science (ARVO) China , 22 May 2025

Opthalmology

Key words: scleral fibroblasts, single-cell transcriptome sequencing, dopamine receptors, scleral remodeling, DRD4

Organism: Human

Tissue: Eye

15
Glioma-neuronal circuit remodeling induces regional immunosuppression

T Nejo, S Krishna, A Yamamichi, S Lakshmanachetty, C Jimenez, KY Lee, DL Baker, JS Young, T Chen, SSS Phyu, L Phung, M Gallus, GC Maldonado, K Okada, H Ogino, PB Watchmaker, D Diebold, A Choudhury, AGS Daniel, CR Cadwell, DR Raleigh, SLJ Hervey-Jumper, H Okada

Nature Communications (Nature) USA , 22 May 2025

Oncology

Key words: Cancer in the nervous system, Cancer microenvironment, CNS cancer, Neuroimmunology, Tumour immunology

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

16
H3K27Me3 abundance is associated with a decreased barrier function of endothelial cells by directly silencing VE-cadherin expression

J Fledderus, B Vanchin, L Brouwer, T Kuiper, RM Jongman, M van Meurs, MC Harmsen, Fuido Krenning

Atherosclerosis (Elsevier) The Netherlands , 20 May 2025

Vascular Biology

Key words: Atherosclerosis, Endothelial barrier, Shear stress, EZH2H3K27Me3, CDH5, VE-Cadherin

Organism: Human

Cell Line: HUVEC

17
p38 MAPK–mediated upregulation of claudin-3 and claudin-4 by gemcitabine contributes to chemoresistance in ovarian cancer

J Zhao, J Ke, X Cao, J Li, M Gu, X Zhou, Y Yan, J Ke

The International Journal Biochemistry and Cell Biology (Elsevier) China , 20 May 2025

Oncology

Key words: Gemcitabine, CLDN3, CLDN4, ADC, p38 MAPK

Organism: Human

Pathological State: Cancer

Cell Line: A2780

18
Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

KZ Wu, RH Ding, Z Zhao, CYL Chong, R You, H Zhou, DH Seah, WQ Leow, HK Lim, S Shyamasundar, K Fernando, FF Kuthubudeen, G Ng, CY Tay, NG Iyer, CAJ Ong, ELS Fong

Advanced Materials (Wiley Online Library) Singapore , 20 May 2025

Oncology

Key words: drug development, hyaluronan hydrogels, patient-derived tumor explants,peritoneal metastases, personalized oncology

Organism: Human

Tissue: Tumor

Pathological State: Cancer

19
Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice

Y Ding, S Yao, S Guo, W Meng, J Li, F Wang, J Zhang, YZ Chang, G Gao

Pharmacological Research (Elsevier) China , 16 May 2025

Neuroscience

Key words: Ferroportin 1, Neural stem cells, Hippocampal neurogenesis, Iron, ROS

Organism: Mouse

Tissue: Brain

20
In situ imaging study of targeted iron and metabolically related molecules in tumors and brain tissues using MALDI-MS imaging

K Han, X Shi, H Zhang, X Jin, Q Zhao, X Li, T Zhang, Y Xie, L Duan, YZ Chang

Talanta (Elsevier) China , 15 May 2025

Neuroscience

Key words: Iron mapping, Iron chelators, MALDI-MSI, Iron metabolism

Organism: Mouse

Tissue: Brain

Results 11 - 20 of 3293
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