Customer Publications (A total of 2648 papers published)

CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer

X Chen, R Xu, D He, Y Zhang, H Chen, Y Zhu, Y Cheng, R Liu, R Zhu, L Gong, M Xiao, Z Wang, L Deng, K Cao

Oncogene (Nature) China, 22 September 2021

Oncology

Key words: Bladder Cancer, Immunotherapy [more]

Early postoperative urinary MCP-1 as a potential biomarker predicting acute rejection in living donor kidney transplantation: a prospective cohort study

HR Jang, M Kim, S Hong, K Lee, MY Park, KE Yang, CJ Lee, J Jeon, KW Lee, JE Lee, JB Park, K Kim, GY Kwon, YG Kim, DJ Kim, W Huh

Scientific Reports (Nature) South Korea, 22 September 2021

Nephrology

Key words: Biomarkers, Kidney Diseases, Predictive Markers, Renal Replacement Therapy [more]

Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research—Application, Toxicity, Cellular Uptake

P Talarska, M Boruczkowski, J Żurawski

Nanomaterials (MDPI) Poland, 21 September 2021

Nanomedicine

Key words: Silver Nanoparticles, Gold Nanoparticles, Nanotoxicology, Nanoparticle Interactions, Nanoparticle Applications [more]

Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

K Takamatsu, N Tanaka, K Hakozaki, R Takahashi, Y Teranishi, T Murakami, R Kufukihara, N Niwa, S Mikami, T Shinojima, T Sasaki, Y Sato, H Kume, S Ogawa, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, K Sawada, T Imamura, R Mizuno, M Oya

Nature Communications (Nature) Japan, 20 September 2021

Oncology

Key words: Cancer Immunotherapy, Cancer Microenvironment, Predictive Markers, Renal Cell Carcinoma, Tumour Biomarkers [more]

PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression

XY Qin, QH Shan, H Fang, Y Wang, P Chen, ZQ Xiong, DF Swaab, JN Zhou

Acta Neuropathologica (Springer) China, The Netherlands, 18 September 2021

Neuroscience

Key words: Depression, Paraventricular Nucleus, PSD-93, Corticotropin-Releasing Hormone, Synaptic Regulation [more]

Interferon Gamma-Induced Interferon Regulatory Factor 1 Activates Transcription of HHLA2 and Induces Immune Escape of Hepatocellular Carcinoma Cells

R Wang, H Guo, X Tang, T Zhang, Y Liu, C Zhang, H Yu, Y Li

Inflammation (Springer) China, 18 September 2021

Oncology, Immunology

Key words: Hepatocellular Carcinoma, HHLA2, Tumor-Associated Macrophages, PD-L1, Immune Escape, IFNG, IFR1 [more]

Experimental nerve transfer model in the neonatal rat

ME Sporer, M Aman, KD Bergmeister, D Depisch, KM Scheuba, E Unger, BK Podesser, OC Aszmann

Neural Regeneration Research (Wolters Kluwer) Austria, 17 September 2021

Regenerative Medicine, Neuroscience

Key words: brachial plexus birth injury, experimental rat model, extremity reconstruction, methodological paper, neonatal rat, nerve reconstruction, nerve regeneration, nerve transfer, neural plasticity, peripheral nerve surgery [more]

Multiomic analysis reveals comprehensive tumor heterogeneity and distinct immune subtypes in multifocal intrahepatic cholangiocarcinoma

SL Chen, Y Xie, Y Cai, H Hu, M He, L Liu, C Liao, Y Wang, J Wang, X Ren, Q Zeng, H Peng, S Shen, SQ Li, D Li, J Lai, B Peng, J Ren, M Kuang, S Peng

Clinical Cancer Research (AACR Publications) China, 15 September 2021

Oncology

Key words: Multifocal Intrahepatic Cholangiocarcinoma, Heterogeneity, Clonal Evolution, Immune Microenvironment, Immunotherapy [more]

Smooth muscle cell CYB5R3 preserves cardiac and vascular function under chronic hypoxic stress

BG Durgin, KC Wood, SA Hahn, B McMahon, JJ Baust, AC Straub

Journal of Molecular and Cellular Cardiology (Elsevier) USA, 15 September 2021

Cardiology

Key words: Smooth Muscle Cell, Redox, Hypoxia, Nitric Oxide, Hypertrophy, Soluble Guanylyl Cyclase [more]

LncRNA PVT1 knockdown ameliorates myocardial ischemia reperfusion damage via suppressing gasdermin D-mediated pyroptosis in cardiomyocytes

C Li, H Song, C Chen, S Chen, Q Zhang, D Liu, J Li, H Dong, Y Wu, Y Liu

Frontiers in Cardiovascular Medicine (Frontiers Media S.A.) China, 14 September 2021

Cardiology

Key words: lncRNA, PVT1, Myocardial Ischemia Reperfusion, Pyroptosis, Gasdermin D [more]

Estimating the time of skeletal muscle contusion based on the spatial distribution of neutrophils: a practical approach to forensic problems

Q Du, L Wang, D Li, J Niu, X Zhang, J Sun

International Journal of Legal Medicine (Springer) China, 13 September 2021

Biological Methods

Key words: Estimating Injury Time, Spatial Distribution, Immunohistochemical, Skeletal Muscle Contusion, Fisher Discriminant Analysis [more]

Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against …

Y Ni, BC Hu, GH Wu, ZQ Shao, Y Zheng, R Zhang, J Jin, J Hong, XH Yang, RH Sun, JQ Liu, SJ Mo

Theranostics (Ivyspring International Publisher) China, 13 September 2021

Immunology

Key words: Neutrophil extracellular traps, Fibroblast growth factor-inducible molecule 14, Macrophages, Homeobox protein Hox-A5, Septic acute kidney injury [more]

N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

J Li, X Hu, T Luo, Y Lu, Y Feng, H Zhang, D Liu, X Fan, Y Wang, L Jiang, Y Wang, X Hao, T Shi, Z Wang

European Journal of Medicinal Chemistry (Elsevier) China, 10 September 2021

Biological Materials

Key words: Glioma, N-2-(Phenylamino) Benzamide, Topoisomerase I Inhibitor, COX-2 Inhibitor, Pseudocycle [more]

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

S Niu, W Shi, Y Li, S Yi, Y Li, X Liu, B Cong, G He

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 08 September 2021

Neuroscience

[more]

Case Study of Noni Extract in Men with Very Low-Risk or Low-Risk Prostate Cancer

Y Hirasawa, I Pagano, JH Pharm, Y Sasaki, K Murakami, CJ Rosser, H Furuya

Hawai 'i Journal of Health & Social Welfare (hawaiijournalhealth.org) USA, 08 September 2021

Oncology

Key words: Prostate Cancer, Active Surveillance, Noni [more]

Autophagy protects murine preputial glands against premature aging, and controls their sebum phospholipid and pheromone profile

H Rossiter, D Copic, M Direder, F Gruber, S Zoratto, M Marchetti-Deschmann, C Kremslehner, M Sochorova, IM Nagelreiter, V Mlitz, M Buchberger, B Lengauer, B Golabi, S Sukseree, M Mildner, L Eckhart, E Tschachler

Autophagy (Taylor & Francis) Austria, 07 September 2021

Aging

Key words: Autophagosomes, GFP-LC3, Lipid Droplets, Perilipin, Sebocytes [more]

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

DR Collins, JM Urbach, ZJ Racenet, U Arshad, KA Power, RM Newman, GH Mylvaganam, NL Ly, X Lian, A Rull, Y Rassadkina, AG Yanez, MJ Peluso, SG Deeks, F Vidal, M Lichterfeld, XG Yu, GD Gaiha, TM Allen, BD Walker

Immunity (Cell Press) USA, Spain, 07 September 2021

Virology, Immunology

Key words: Human Immunology, HIV Control, CD8+ T Cell Dysfunction [more]

Reciprocal regulation of endothelial–mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease

B Vanchin, M Sol, RAF Gjaltema, M Brinker, B Kiers, AC Pereira, MC Harmsen, JAJ Moonen, G Krenning

Scientific Reports (Nature) The Netherlands, Mongolia, Brazil, 07 September 2021

Cardiology

Key words: Cell Signalling, Epigenetics, Mechanisms of Disease, Non-Coding Rnas, Pathogenesis, Vascular Diseases [more]

PAC1 receptor mediates electroacupuncture-induced neuro and immune protection during cisplatin chemotherapy

S Li, J Huang, Y Guo, J Wang, S Lu, B Wang, Y Gong, S Qin, S Zhao, S Wang, Y Liu, Y Fang, Y Guo, Z Xu, L Ulloa

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 06 September 2021

Oncology, Pharmacology

Key words: Neuromodulation, Chemotherapy, Immunosuppression, Hematopoiesis, Neurotoxic, Electroacupuncture [more]

Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease

L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen

Brain, Behavior, and Immunity (Elsevier) China, 06 September 2021

Neuroscience

Key words: β -Secretase, CD4+ T Cell, PGE2 Signalling, Alzheimer's Disease, Neuroinflammation, T Cell Receptor (TCR) [more]

Single‐cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer

H Lai, X Cheng, Q Liu, W Luo, M Liu, M Zhang, J Miao, Z Ji, GN Lin, W Song, L Zhang, J Bo, G Yang, J Wang, WQ Gao

International Journal of Cancer (Wiley) China, 03 September 2021

Oncology

[more]

Decompartmentalisation as a simple color manipulation of plant-based marbling meat alternatives

S Ong, L Loo, M Pang, R Tan, Y Teng, X Lou, SK Chin,MY Naik, H Yu

Biomaterials (Elsevier) Singapore, 03 September 2021

Biological Materials, Tissue Engineering

Key words: Cell-Based Meat, Edible Scaffold, Meat Marbling, Cellulose, Polyphenol, Organoleptic [more]

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

C Gribben, C Lambert, HA Messal, EL Hubber, C Rackham, I Evans, H Heimberg, P Jones, R Sancho, A Behrens

Cell Stem Cell (Cell Press) UK, Belgium, Germany, 02 September 2021

Stem Cell Research

Key words: β Cells, Pancreas, Diabetes, δ Cells, Lineage Tracing, Ngn3, Progenitor, Regeneration [more]

Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration

YS Hsueh, YJ Shyong, HC Yu, SJ Jheng, SW Lin, HL Wu, JC Tsai

Pharmaceutics (MDPI) Taiwan, 02 September 2021

Biological Materials

Key words: Nanostructured Lipid Carrier, Protein Drug Delivery, Sustained Release, Chronic Wound Healing, Angiogenesis Factor, Carbopol Gel, Thrombomodulin [more]

A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution

H Yang, S Yang, F Fan, Y Li, S Dai, X Zhou, CC Steiner, B Coppedge, C Roos, X Cai, DM Irwin, P Shi

Molecular Biology and Evolution (Oxford Academic) China, USA, Germany, Canada, 01 September 2021

Genetics, Evolution

Key words: Convergent Evolution, Bitter Taste Receptors, Tas2R16, Human, White-Faced Saki, Pithecia Pithecia, Adaptive Evolution [more]

Improving Mask R-CNN for Nuclei Instance Segmentation in Hematoxylin & Eosin-Stained Histological Images

B Bancher, A Mahbod, I Ellinger, R Ecker, G Dorffner

Proceedings of Machine Learning Research (PMLR) Austria, 01 September 2021

Machine Learning

Key words: Mask R-CNN, Nuclei Segmentation, Medical Image Analysis, Deep Learning, Computational Pathology

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation

M Rath, A Pitiot, M Kirr, W Fröhlich, B Plosnita, S Schliep, J Bauerschmitz, AS Baur, C Ostalecki

International Journal of Molecular Sciences (MDPI) Germany, UK, Austria, 30 August 2021

Dermatology

Key words: Scar, Dendritic Cells, Tumor Microenvironment, Single-Cell Analysis, Multiplex Imaging, Proteases, Tumor Biology [more]

Diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

WZ Wang, X Liu, ZY Yang, YZ Wang, HT Lu

Neural Regeneration Research (Wolters Kluwer) China, 30 August 2021

Neuroscience

Key words: brain-derived neurotrophic factor, diffusion tensor imaging, fractional anisotropy value, global cerebral ischemia/reperfusion injury, hippocampus, TrkB [more]

Characteristics of Chlamydia suis Ocular Infection in Pigs

C Unterweger, A Inic-Kanada, S Setudeh, C Knecht, S Duerlinger, M Stas, D Vanrompay, C Kiekens, R Steinparzer, W Gerner, A Ladinig, T Barisani-Asenbauer

Pathogens (MDPI) Austria, Belgium, 29 August 2021

Microbiology

Key words: Chlamydia Suis, Piglets, Experimental Conjunctival Infection, Serology, Antibodies, Immunohistochemistry, Lacrimal Gland [more]

Bone Marrow Remodelling Supports Hematopoiesis in Response to Immune Thrombocytopenia Progression in Mice

OJ Herd, GF Rani, JP Hewitson, K Hogg, AP Stone, N Cooper, DG Kent, PG Genever, IS Hitchcock

Blood Advances (Elsevier) UK, 26 August 2021

Hematology

[more]

TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

E Gonzalez-Buendia, J Zhao, L Wang, S Mukherjee, D Zhang, VA Arrieta, E Feldstein, JR Kane, SJ Kang, C Lee-Chang, A Mahajan, L Chen, R Realubit, C Karan, L Magnuson, C Horbinski, SA Marshall, JN Sarkaria, A Mohyeldin, I Nakano, M Bansal, CD James, DJ Brat, A Ahmed, P Canoll, R Rabadan, A Shilatifard, AM Sonabend

Clinical Cancer Research (AACR Publications) USA, 25 August 2021

Oncology

[more]

Biocompatible Copper Sulfide Based Nanocomposites for Artery Interventional Chemo-Photothermal Therapy of Orthotropic Hepatocellular Carcinoma

X Li, H Yuan, X Tian, J Tang, L Liu, F Liu

Materials Today Bio (Elsevier) China, 25 August 2021

Nanomedicine

Key words: DOX@BSA-CuS Nanocomposites, NIR-Responsive, Photothermal Ablation, Chemoembolization, MRI Guided Therapy [more]

Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

R Herzog, JM Sacnun, G González-Mateo, M Bartosova, K Bialas, A Wagner, M Unterwurzacher, IJ Sobieszek, L Daniel-Fischer, K Rusai, L Pascual-Antón, K Kaczirek, A Vychytil, C Peter Schmitt, M López-Cabrera, SL Alper, C Aufricht, K Kratochwill

Science Translational Medicine (AAAS) Austria, Spain, Germany, USA, 25 August 2021

Nephrology

[more]

Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

TH Hung, JT Hung, CE Wu, Y Huang, CW Lee, CT Yeh, YH Chung, FY Lo, LC Lai, JK Tung, J Yu, CN Yeh, AL Yu

Hepatology Communications (Wiley) Taiwan, 24 August 2021

Hepathology, Oncology

[more]

Oroxylin A promotes therapeutic efficacy of cisplatin to suppress bladder cancer progression via inducing ferroptosis

Q Tang, J Jiang, J Sun, L Tang, X Zhang

Biochemical and Biophysical Research Communications (Elsevier) China, 21 August 2021

Oncology, Pharmacology

Key words: Bladder Cancer, cDDP, Oroxylin A (OroA), Ferroptosis [more]

Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity

V Azzimato, P Chen, E Barreby, C Morgantini, L Levi, A Vankova, J Jager, A Sulen, M Diotallevi, JX Shen, A Miller, E Ellis, M Rydén, E Näslund, A Thorell, VM Lauschke, KM Channon, MJ Crabtree, A Haschemi, Sm Craige, M Mori, F Spallotta, M Aouadi

Gastroenterology (Elsevier) Sweden, France, UK, Austria, Germany, USA, Italy, 21 August 2021

Gastroenterology

Key words: Liver, Metabolism, Oxidative Stress, miRNAs, Fumarase [more]

Spatially Resolved Immunometabolism to Understand Infectious Disease Progression

R Tans, S Dey, NS Dey, G Calder, P O'Toole, PM Kaye, RMA Heeren

Frontiers in Microbiology (Frontiers Media S.A.) The Netherlands, UK, 19 August 2021

Immunology

Key words: Immunometabolism, Infectious Disease, Inflammation, Granulomas, Mass Spectrometry Imaging, Spatial Transcriptomics, Multi-Omics, Leishmaniasis

Maternal Immune Activation Causes Social Behavior Deficits and Hypomyelination in Male Rat Offspring with an Autism-Like Microbiota Profile

GA Lee, YK Lin, JH Lai, YC Lo, YCSH Yang, SY Ye, CJ Lee, CC Wang, YH Chiang, SH Tseng

Brain Sciences (MDPI) Taiwan, 18 August 2021

Neuroscience

Key words: Autism Spectrum Disorder, Lipopolysaccharide, Maternal Immune Activation, Microbiota, Three-Chamber Test, Myelination, Brain–Gut–Microbiota Axis, Social Behavior Deficits [more]

Effects of Vitamin D-Deficient Diet on Intestinal Epithelial Integrity and Zonulin Expression in a C57BL/6 Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, CB Jiang, SW Chang, CY Liu, CW Chang, HC Lee

Frontiers in Medicine (Frontiers Media S.A.) Taiwan, 16 August 2021

Gastroenterology

Key words: Vitamin D, Gut Integrity, Tight Junction, Zonulin, Leaky Gut [more]

A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

X He, L Ding, K Cao, H Peng, C Gu, Y Li, D Li, L Dong, X Hong, X Wang, M Fu, C Qiu, C Zhu, Z Zhang, S Song, C Wang, Z Jiang, Y Xie, Z Qi, C Zhao, P Zhao, X Zhang, J Xu

Emerging Microbes & Infections (Taylor & Francis) China, 12 August 2021

SARS-CoV-2

Key words: SARS-CoV-2, Cell-Based Vaccines, K562-S, Mouse Model, Non-Human Primate Model, Neutralizing Antibody, Protection [more]

Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus

D Douchi, A Yamamura, J Matsuo, YHM Lim, N Nuttonmanit, M Shimura, K Suda, S Chen, S Pang, K Kohu, T Abe, G Shioi, G Kim, A Shabbir, S Srivastava, M Unno, JBY So, M Teh, KG Yeoh, LSH Chuang, Y Ito

Gastroenterology (Elsevier) Singapore, Japan, 12 August 2021

Gastroenterology

Key words: Metaplasia, Intramucosal Dysplasia, Invasive and Metastatic Gastric Cancer, Gastric Carcinogenesis, Mouse Model [more]

Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells

L Kappert, P Ruzicka, A Kutikhin, C De La Torre, A Fischer, M Hecker, C Arnold, T Korff

The FASEB Journal (Wiley) Germany, Russia, 12 August 2021

Cardiology

[more]

The role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells

PJ Kung, TY Lai, J Cao, LC Hsu, TC Chiang, P Ou-Yang, CY Tsai, YF Tsai, CW Lin, CC Chen, MK Tsai, YW Tien, CY Lee

Cancer Immunology, Immunotherpay (Springer) Taiwan, Australia, 10 August 2021

Oncology, Immunology

Key words: S100A9, PD-L1, Pancreatic Ductal Adenocarcinoma, PSC [more]

Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer

E Shrestha, JB Coulter, W Guzman, B Ozbek, MM Hess, L Mummert, SE Ernst, JP Maynard, AK Meeker, CM Heaphy, MC Haffner, AM De Marzo, KS Sfanos

PNAS (United States National Academy of Sciences) USA, 10 August 2021

Oncology

Key words: Prostate Cancer, Infection, Inflammation, TMPRSS2:ERG Fusion, Colibactin [more]

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium

CC Lai, SH Tseng, SM Hsu, YT Huang, CC Shieh

Investigative Ophthalmology & Visual Science (ARVO Journals) Taiwan, 09 August 2021

Ophthalmology

Key words: Pterygium, Pterygial Epithelial Cells, Toll-Like Receptor 3, Ultraviolet B, NF-κB [more]

Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer

SC Wang, YC Chang, MY Wu, CY Yu, SL Chen, WW Sung

Cancers (MDPI) Taiwan, 04 August 2021

Oncology

Key words: Bladder Cancer, Azacitidine, Intravesical Instillation, TNF-R1, TRAIL-R2 [more]

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

LC Russo, R Tomasin, IA Matos, AC Manucci, ST Sowa, K Dale, KW Caldecott, L Lehtiö, D Schechtman, FC Meotti, A Bruni-Cardoso, NC Hoch

Journal of Biological Chemistry (ASBMB) Brazil, Finland, UK, 04 August 2021

SARS-CoV-2, Immunology

Key words: COVID-19, SARS-CoV-2, ADP-ribosylation, PARP9, DTX3L, macrodomain [more]

Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway

X Wu, Z Wang, Y Jiang, H Zhou, A Li, Y Wie, Z Bao, D Wang, J Zhao, X Chen, Y Guo, Z Dong, K Liu

Frontiers in Oncology (Frontiers Media S.A.) China, 04 August 2021

Oncology

Key words: Esophageal Squamous Cell Carcinoma, Tegaserod Maleate, Proteome, Peroxisome, Peroxisome Membrane Protein 11B, Peroxisome Membrane Protein 13, Patient-Derived Xenograft [more]

Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma

M Ma, G Li, M Qi, W Jiang, R Zhou

Frontiers in Immunology (Frontiers Media S.A.) China, 03 August 2021

Immunology

Key words: Asthma, Inflammasome, HDM, Alveolar Macrophage, RRx-001, NLRP3 [more]

The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

T Gao, P Yang, D Fu, M Liu, X Deng, M Shao, J Liao, H Jiang, X Li

Aging (Impact Journals) China, 03 August 2021

Cardiology

Key words: Allicin, Apoptosis, PI3K/Akt Pathway, Myocardial Ischemia/Reperfusion, Gene Expression Profiling, Calcium Signaling Pathway, GRK2, GPCR [more]

High-Precision Quantitative Analysis Reveals Carcinoembryonic Protein Expression Differs Among Colorectal Cancer Primary Foci and Metastases to Different Sites

Y Zhu, Q Zhang, C Wei, Y Hu, H Gong, Y Liu, H Lai, Y Feng, Y Lin

Technology in Cancer Research & Treatment (SAGE Journals) China, 03 August 2021

Oncology

Key words: Carcinoembryonic Protein, Colorectal Cancer, Lymph Node Metastases, Liver Metastases, Primary Foci [more]

Conifer essential oils reversed amyloid beta1-42 action by modulating BDNF and ARC expression in the rat hippocampus

PA Postu, A Tiron, CE Tiron, DL Gorgan, M Mihasan, L Hritcu

CNS & Neurological Disorders (ingentaconnect) Romania, 30 July 2021

Neuroscience

Key words: Alzheimer's disease, Pinus halepensis, Tetraclinis articulata, amyloid-beta peptide, memory, neuroprotection [more]

Causal evidence for induction of pessimistic decision-making in primates by the network of frontal cortex and striosomes

S Amemori, AM Graybiel, K Amemori

Frontiers in Neuroscience (Frontiers Media S.A.) Japan, USA, 30 July 2021

Neuroscience

Key words: Anxiety, Caudal Orbitofrontal Cortex, Pregenual Anterior Cingulate Cortex, Approach-Avoidance Conflict, Monkey, Microstimulation, Striosome Compartment, Caudate Nucleus [more]

S-nitroso human serum albumin as a nitric oxide donor in drug-eluting vascular grafts: biofunctionality and preclinical evaluation

M Enayati, KH Schneider, C Almeria, C Grasl, C Kaun, B Messner, S Rohringer, I Walter, J Wojta, L Budinsky, BH Walpoth, H Schima, G Kager, S Hallström, BK Podesser, H Bergmeister

Acta Biomaterialia (Elsevier) Austria, Slovakia, Switzerland, 28 July 2021

Cardiology

Key words: Nitric Oxide Donor, Drug Eluting Vascular Graft, Poly-Caprolactone, Electrospinning [more]

Myeloid cells are enriched in tonsillar crypts providing insight into the host tropism of HPV

AK Mattox, J Roelands, TM Saal, Y Cheng, D Rinchai, W Hendrickx, GD Young, TJ Diefenbach, AE Berger, WH Westra, JA Bishop, WC Faquin, FM Marincola, MJ Pittet, D Bedognetti, SI Pai

The American Journal of Pathology (Elsevier) USA, Qatar, The Netherlands, 23 July 2021

Virology

[more]

Liposomal IR-780 as a Highly Stable Nanotheranostic Agent for Improved Photothermal/Photodynamic Therapy of Brain Tumors by Convection-Enhanced Delivery

YJ Lu, TS Anikumar, CC Chuang, JP Chen

Cancers (MDPI) Taiwan, 22 July 2021

Oncology

Key words: Nanomedicine, Cancer Therapy, Brain Tumor, Photothermal Therapy, Photodynamic Therapy, Liposome, IR-780, Convection Enhanced Delivery [more]

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

WH Yang, JS Westman, DM Heithoff, M Sperandio, JW Cho, MJ Mahan, JD Marth

PNAS (United States National Academy of Sciences) USA, South Korea, Germany, 20 July 2021

Gastroenterology

Key words: Colitis, Neuraminidase, Inflammation [more]

Electromagnetic Field‐Programmed Magnetic Vortex Nanodelivery System for Efficacious Cancer Therapy

X Liu, Y Zhang, Y Guo, W Jiao, X Gao, WSV Lee, Y Wang, X Deng, Y He, J Jiao, C Zhang, G Hu, XJ Liang, H Fan

Advanced Science (Wiley) China, Singapore, 18 July 2021

Nanomedicine, Oncology

[more]

Effect of high fat diet on the severity and repair of lung fibrosis in mice

AE Hegab, M Ozaki, S Kagawa, K Fukunaga

Stem Cells and Development (Mary Ann Liebert Inc.) Japan, 16 July 2021

Endocrinology, Pulmonology

Key words: High Fat Diet, Fibrosis, Alveolar Type-2 Cells, Bronchioalveolar Stem Cells, Fatty Acid Oxidation [more]

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

R Fardoos, OE Asowata, N Herbert, SK Nyquist, Y Zungu, A Singh, A Ngoepe, IM Mbano, N Mthabela, D Ramjit, F Karim, W Kuhn, FG Madela, VT Manzini, F Anderson, B Berger, TH Pers, AK Shalek, A Leslie, H Kløverpris

JCI Insight (The American Society for Clinical Investigation) Denmark, South Africa, USA, 12 July 2021

SARS-CoV-2

Key words: AIDS/HIV, Covid-19 [more]

Down-regulation of A20 promotes immune escape of lung adenocarcinomas

K Breitenecker, M Homolya, AC Luca, V Lang, C Trenk, G Petroczi, J Mohrherr, J Horvath, S Moritsch, L Haas, M Kurnaeva, R Eferl, D Stoiber, R Moriggl, M Bilban, AC Obenauf, C Ferran, B Dome, V Laszlo, B Györffy, K Dezso, J Moldvay, E Casanova, HP Moll

Science Translational Medicine (AAAS) Austria, USA, Hungary, 07 July 2021

Oncology, Pulmonology

[more]

Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle

C Romagnoli, P Sharma, R Zonefrati, G Palmini, E Lucattelli, DT Ward, I Ellinger, M Innocenti, ML Brandi

International Journal of Molecular Sciences (MDPI) Italy, UK, Austria, 06 July 2021

Osteology

Key words: Skeletal Muscle, Satellite Cells, Myogenesis, Calcium-Sensing Receptor, G Protein-Coupled Receptors [more]

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess

Cells (MDPI) The Netherlands, Australia, Indonesia, Canada, 29 June 2021

Pulmonology

Key words: Extracellular Matrix, Senescence, Idiopathic Pulmonary Fibrosis, Proinflammatory, Profibrotic [more]

Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo

CC Ku, K Wuputra, K Kato, JB Pan, CP Li, MH Tsai, M Noguchi, Y Nakamura, CJ Liu, TF Chan, MF Hou, S Wakana, YC Wu, CS Lin, DC Wu, KK Yokoyama

Stem Cell Research & Therapy (BMC) Taiwan, Japan, 29 June 2021

Neuroscience

Key words: Antioxidation, Cerebellum, Granule Cells, Jun Dimerization Protein 2 (Jdp2), Reactive Oxygen Species (ROS) [more]

Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma

J Xu, N Yu, P Zhao, F Wang, J Huang, Y Cui, H Ding, Y Yang, Y Gao, L Pan, H Chang, Y Wu, B Xiang, Y Gong, X Shuai, L Hou, L Xie, T Niu, T Liu, L Zhang, W Liu, W Zhang, Y Qu, W Lin, Y Zhu, S Zhao, Y Zheng

Frontiers in Oncology (Frontiers Media S.A.) China, 29 June 2021

Oncology

Key words: Extramedullary Multiple Myeloma, MIF, Immunohistochemistry Staining, Xenograft Models, Single-Cell Sequencing [more]

Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy

YX Hong, WY Wu, F Song, C Wu, GR Li, Y Wang

Aging (Impact Journals) China, 27 June 2021

Cardiology

Key words: Cardiac Senescence, Telomere Length Shortening, Mitophagy, Sirt1, Sirt6, pAMPK [more]

Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells

Z Wu, F Wang, L Hu, J Zhang, D Chen, S Zhao

Ecotoxicology and Environmental Safety (Elsevier) China, 25 June 2021

Toxicology

Key words: MCLR, Autophagy, Endoplasmic Reticulum Stress, Apoptosis, Zebrafish [more]

Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors

T Sim, B Choi, SW Kwon, KS Kim, H Choi, A Ross, DH Kim

ACS NANO (ACS Publications) USA, 24 June 2021

Nanomedicine

Key words: Natural Killer Cell, Magneto-Activation, Nanocomplexes, Cell Labeling, Cancer Therapy [more]

Omega-Class Glutathione Transferases of Carcinogenic Liver Fluke, Clonorchis sinensis, Modulate Apoptosis and Differentiation of Host Cholangiocytes

CS Ahn, JG Kim, I Kang, Y Kong

Antioxidants (MDPI) South Korea, 24 June 2021

Parasitology

Key words: Clonorchis Sinensis, Omega-Class Glutathione Transferase, Cholangiocyte, Oxidative Stress, Programmed Cell Death, Cell Differentiation, Protein Kinase, Gene Regulation [more]

Hematological consequences of malaria in mice previously treated for visceral leishmaniasis

GF Rani, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Wellcome Open Research (Wellcome Open Research) UK, 18 June 2021

Parasitology

Key words: visceral leishmaniasis, malaria, mouse models, hematology, chemotherapy, coinfection [more]

Investigating Transcriptional Dynamics Changes and Time-Dependent Marker Gene Expression in the Early Period After Skeletal Muscle Injury in Rats

K Ren, L Wang, L Wang, Q Du, J Cao, Q Jin, G An, Na Li, L Dang, Y Tian, Y Wang, J Sun

Frontiers in Genetics (Frontiers Media S.A.) China, 17 June 2021

Genetics

Key words: Time-Series RNA-Seq, Gene Expression and Regulation Landscape, Time-Related Biomarkers, Transcriptional Dynamics, Skeletal Muscle Injury [more]

DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice

J Qin, Y Zhu, Y Ding, T Niu, Y Zhang, H Wu, L Zhu, B Yuan, Y Qiao, J Lu, K Liu, Z Dong, G Jin, X Chen, J Zhao

Neoplasia (Elsevier) China, 15 June 2021

Oncology

Key words: Polβ, NMBA, Esophageal Precancerous Lesion [more]

Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

H Mathsyaraja, J Catchpole, B Freie, E Eastwood, E Babaeva, M Geuenich, PF Cheng, J Ayers, M Yu, N Wu, S Moorthi, KR Poudel, A Koehne, W Grady, AM Houghton, AH Berger, Y Shiio, D MacPherson, RN Eisenman

eLife (eLife Sciences Publications) USA, 11 June 2021

Oncology

Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice

NR Rao, JN Savas

Journal of Proteome Research (ACS Publications) USA, 09 June 2021

Cell Biology

Key words: Mass Spectrometry, Peptides and Proteins, Central Nervous System, Rodent Models, Endocytosis [more]

A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40‐IL‐13 Receptor α2 Axis

Y van Sleen, WF Jiemy, S Pringle, KSM van der Geest, WH Abdulahad, M Sandovici, E Brouwer, P Heeringa, AMH Boots

Arthritis & Rheumatology (Wiley) The Netherlands, Malaysia, 08 June 2021

Rheumatology

[more]

A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer

SC Chang, CS Hung, BX Zhang, TH Hsieh, W Hsu, JL Ding

Cancers (MDPI) Taiwan, 08 June 2021

Oncology

Key words: CCNF, FBXL8, FZR1, RRM2, E3 Ubiquitin Ligase, Breast Cancer, Metastasis [more]

Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma

SA O'Connor, HM Feldman, S Arora, P Hoellerbauer, CM Toledo, P Corrin, L Carter, M Kufeld, H Bolouri, R Basom, J Delrow, JL McFaline-Figueroa, C Trapnell, SM Pollard, A Patel, PJ Paddison, CL Plaisier

Molecular Systems Biology (EMBO press) USA, UK, 08 June 2021

Neuroscience

[more]

Determining optimal clinical target volume margins in high-grade glioma based on microscopic tumor extension and magnetic resonance imaging

S Nie, Y Zhu, J Yang, T Xin, S Xue, X Zhang, J Sun, D Mu, Y Gao, Z Chen, X Ding, J Yu, M Hu

Radiation Oncology (BMC) China, 07 June 2021

Oncology

Key words: High-Grade Glioma, Macropathology, Microscopic Extension, Predictive Model, Clinical Target Volume, Radiotherapy [more]

Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer

W Liu, Y Wang, Y Xie, T Dai, M Fan, C Li, Y Zou

Cell Death Discovery (Nature) China, 05 June 2021

Oncology

Key words: Cancer Microenvironment [more]

Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment

O Nebie, K Carvalho, L Barro, L Delila, E Faivre, TY Renn, M-Li Chou, YW Wu, A Niem-Redene, SY Chou, L Buée, CJ Hu, Chih-Wei Peng, D Devos, D Blum, T Burnouf

Brain (Oxford Academic) Taiwan, France, 04 June 2021

Neuroscience

Key words: Human Platelet Lysate, Traumatic Brain Injury, Neuroprotection, Neurorestoration, Neurotrophins [more]

MoNuSAC2020: A Multi-organ Nuclei Segmentation and Classification Challenge

R Verma, N Kumar, A Patil, NC Kurian, S Rane, S Graham, QD Vu, M Zwager, SEA Raza, N Rajpoot, X Wu, H Chen, Y Huang, L Wang, H Jung, GT Brown, Y Liu, S Liu, SAF Jahromi, AA Khani, E Montahaei, MS Baghshah, H Behroozi, P Semkin, A Rassadin, P Dutande, R Lodaya, U Baid, B Baheti, S Talbar, A Mahbod, R Ecker, I Ellinger, Z Luo, B Dong, Z Xu, Y Yao, S Lv, M Feng, K Xu, H Zunair, AB Hamza, S Smiley, TK Yin, QR Fang, S Srivastava, D Mahapatra, L Trnavska, H Zhang, PL Narayanan, J Law, Y Yuan, A Tejomay, A Mitkari, D Koka, V Ramachandra, L Kini, A Sethi

IEEE Transactions on Medical Imaging (IEEE Xplore) USA, Canada, India, The Netherlands, China, USA, China, Iran, Russia, Austria, Taiwan, UAE, Slovakia, UK, 04 June 2021

Medical Image Analysis

Key words: Multi-Organ Dataset, Nucleus Classification, Computational Pathology, Instance Segmentation, Panoptic Quality

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

KP Hammer, J Mustroph, T Stauber, W Birchmeier, S Wagner, LS Maier

PLoS One (PLOS) Germany, 04 June 2021

Physiology

Key words: Exercise, Running, Arrhythmia, Mouse Models, Heterozygosity, Phosphorylation, Physical Activity, Sedentary Behavior [more]

Synthetic Fibrin-Derived Bβ15-42 Peptide Delays Thrombus Resolution in a Mouse Model

S Chausheva, B Redwan, S Sharma, N Marella, K Schlossleitner, AC Mueller, P Petzelbauer, T Morris, IM Lang

Arteriosclerosis, Thrombosis and Vascular Biology (American Heart Association) Austria, Germany, 03 June 2021

Cardiology

Key words: Macrophages, Microvessels, Monocyte, Plasma, Venous Thrombosis [more]

Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study

CE Tiron, E Patrașcanu, PA Postu, IC Vacarean Trandafir, A Tiron, I Grigoras

Current Issues in Molecular Biology (MDPI) Romania, 02 June 2021

Oncology

Key words: AKT, Breast Cancer, EMT, HIF, Sevoflurane, Vimentin [more]

Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer

J Jiang, DL Huang, Y Jiang, J Hou, MY Tian, JH Li, Li Sun, YG Zhang, T Zhang, ZQ Li, ZC Li, SX Tong

Frontiers in Oncology (Frontiers Media S.A.) China, 02 June 2021

Oncology

Key words: Lactate, Lactylation, Metabolism, Gene Expression, Non-Small Cell Lung Cancer [more]

Disruption of Tfh: B cell interactions prevents antibody-mediated rejection in a kidney transplant model in rats: impact of calcineurin inhibitor dose

L Steines, H Poth, A Schuster, K Amann, B Banas, T Bergler

Frontiers in Immunology (Frontiers Media S.A.) Germany, 31 May 2021

Transplantation Medicine

Key words: Antibody-Mediated Rejection, Donor-Specific Antibodies, Kidney Transplantation, T Follicular Helper Cells, B Cell Activation, Calcineurin Inhibitor [more]

Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation

JP Hohensinner, M Lenz, P Haider, J Mayer, M Richter, C Kaun, L Goederle, M Brekalo, M Salzmann, S Sharma, MB Fischer, S Stojkovic, D Ramsmayer, C Hengstenberg, BK Podesser, K Huber, CJ Binder, J Wojta, WS Speidl

Biochemical Pharmacology (Elsevier) Austria, 28 May 2021

Endocrinology

[more]

Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma

JY Chen, WH Cheng, KY Lee, HP Kuo, KF Chung, CL Chen, BC Chen, CH Lin

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, UK, 27 May 2021

Pulmonology

Key words: Chronic Obstructive Asthma, Airway Fibrosis, ADAM17, EGFR, Human Lung Fibroblasts [more]

Investigating the Impact of the Bit Depth of Fluorescence-Stained Images on the Performance of Deep Learning-Based Nuclei Instance Segmentation

A Mahbod, G Schaefer, C Löw, G Dorffner, R Ecker, I Ellinger

Diagnostics (MDPI) Austria, UK, 27 May 2021

Medical Image Analysis

Key words: Bit Depth, Nuclei Segmentation, Fluorescence Staining, Medical Image Analysis, Computational Pathology, Deep Learning

Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection

WF Garcia-Beltran, DT Claiborne, CR Maldini, M Phelps, V Vrbanac, ME Karpel, KL Krupp, KA Power, CL Boutwell, AB Balazs, AM Tager, M Altfeld, TM Allen

Frontiers in Immunology (Frontiers Media S.A.) USA, Germany, 26 May 2021

Immunology

Key words: Innate Immunity, T Cells, HIV-1, HuBLT, BLT, Humanized Mice [more]

Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers

W Park, SJ Kim, P Cheresh, J Yun, B Lee, DW Kamp, DH Kim

Biomaterials Science (Royal Society of Chemistry) USA, South Korea, 26 May 2021

Oncology

[more]

Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response

I Vargova, L Machova Urdzikova, K Karova, B Smejkalova, T Sursal, V Cimermanova, K Turnovcova, CD Gandhi, M Jhanwar-Uniyal, P Jendelova

Biomedicines (MDPI) Czech Republic, USA, 24 May 2021

Regenerative Medicine, Neuroscience

Key words: Spinal Cord Injury, mTOR, Rapamycin, pp242, Dual Inhibition, Autophagy, Inflammation [more]

Remdesivir Alleviates Acute Kidney Injury by Inhibiting the Activation of NLRP3 Inflammasome

L Yin, H Zhao, H Zhang, Y Li, Y Dong, H Ju, F Kong, S Zhao

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 21 May 2021

Immunology, Pharmacology

Key words: Remdesivir, NLRP3 Inflammasome or NOD-, LRR-, Pyrin Domain-Containing Protein 3 (NLRP3)Inflammasome, NF-κB, Macrophage, Acute Kidney Injury [more]

Evaluation of a Novel Tilapia-skin Acellular Dermis Matrix Rationally Processed for Enhanced Wound Healing

D Li, WQ Sun, T Wang, Y Gao, J Wu, Z Xie, J Zhao, C He, M Zhu, S Zhang, P Wang, X Mo

Materials Science and Engineering: C (Elsevier) China, 21 May 2021

Tissue Engineering

Key words: Tilapia Skin, Decellularization, Wound Healing, Degradation, Re-Epithelialization [more]

Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice

HJ Shih, CY Chang, M Chiang, VL Le, HJ Hsu, CJ Huang

Journal of Personalized Medicine (MDPI) Taiwan, Vietnam, 20 May 2021

Pharmacology

Key words: TNF-α, IL-1β, IL-6, Necroptosis, Pyroptosis, Apoptosis, Liver [more]

Piezo2 downregulation via the Cre-lox system affects aqueous humor dynamics in mice

J Fang, F Hou, S Wu, Y Liu, L Wang, J Zhang, N Wang, K Wang, W Zhu

Molecular Vision (Emory University) China, 20 May 2021

Ophthalmology

[more]

Tissue image cytometry

A Meshcheryakova, F Mungenast, R Ecker, D Mechtcheriakova

Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 1 (IOP Publishing) Austria, 15 May 2021

Medical Image Analysis

Modulation of the anticancer activities of paclitaxel by Cremophor micelles

JL Chiang, YW Yang

International Journal of Pharmaceutics (Elsevier) Taiwan, 14 May 2021

Oncology

Key words: Cell Cycle, Cremophor, Micelle, Paclitaxel, Polyploidy [more]

A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo

YW Wu, MW Chao, HJ Tu, LC Chen, KC Hsu, JP Liou, CR Yang, SC Yen, WC HuangFu, SL Pan

Oncogenesis (Nature) Taiwan, China, 13 May 2021

Oncology

Key words: Drug Development, Drug Discovery and Development [more]

Intravital mesoscopic fluorescence molecular tomography allows non-invasive in vivo monitoring and quantification of breast cancer growth dynamics

MS Ozturk, MG Montero, L Wang, LM Chaible, M Jechlinger, R Prevedel

Communications Biology (Nature) Turkey, Germany, 11 May 2021

Oncology

Key words: 3-D Reconstruction, Fluorescence Imaging, Molecular Imaging, Optical Imaging, Time-Lapse Imaging [more]

Machine-perfused donor kidneys as a source of human renal endothelial cells

RGM Lammerts, LM Lagendijk, G Tiller, WA Dam, HL Lancaster, MR Daha, MA Seelen, BG Hepkema, RA Pol, HGD Leuvenink, G Molema, J van den Born, SP Berger

American Journal of Physiology (APS Journals) The Netherlands, 11 May 2021

Nephrology

Key words: Donation, Endothelial Cells, Kidney, Machine Perfusion, Perfusate, Transplantation [more]

Delta oscillation underlies the interictal spike changes after repeated transcranial direct current stimulation in a rat model of chronic seizures

YJ Wu, ME Chien, CC Chiang, YZ Huang, DM Durand, KS Hsu

Brain Stimulation (Elsevier) Taiwan, USA, 11 May 2021

Neuroscience

Key words: Seizure, Epilepsy, Electroencephalography (EEG), Oscillation, Interictal Spikes, Transcranial Direct Current Stimulation (tDCS) [more]

Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

J Kim, Y Moon

Communications Biology (Nature) South Korea, 10 May 2021

Oncology

Key words: Cancer Microenvironment, Pharmacodynamics [more]

Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart

S Jelinkova, Y Sleiman, P Fojtík, F Aimond, A Finan, G Hugon, V Scheuermann, D Beckerova, O Cazorla, M Vincenti, P Amedro, S Richard, J Jaros, P Dvorak, A Lacampagne, G Carnac, V Rotrekl, AC Meli

International Journal of Molecular Sciences (MDPI) Czech Republic, France, 10 May 2021

Cardiology

Key words: Duchenne Muscular Dystrophy, mdx Mouse, Cardiovascular Progenitors, C-Kit, Genomic Instability, Dilated Cardiomyopathy [more]

Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase

W Mai, L Kong, H Yu, J Bao, C Song, G Qu

Bioscience Reports (Portland Press) China, 10 May 2021

Oncology

Key words: Human Osteosarcoma, Metastasis, Glycogen Synthase Kinase 3β [more]

Neutralizing Anti-Interleukin-1 Receptor-Antagonist Autoantibodies Induce Inflammatory and Fibrotic Mediators in IgG4-Related Disease

JA Jarrell, MC Baker, CA Perugino, H Liu, MS Bloom, T Maehara, HH Wong, Tobias Lanz, JZ Adamska, S Kongpachith, J Sokolove, JH Stone, SS Pillai, WH Robinson

Journal of Allergy and Clinical Immunology (Elsevier) USA, Germany, 08 May 2021

Immunology

Key words: IL-1 Receptor-Antagonist (IL1-RA), IgG4-RD (IgG4-RD), Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis (MS), Immunoglobulin (Ig) [more]

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway

T Zhu, L Wang, W Xie, X Meng, Y Feng, G Sun, X Sun

Frontiers in Pharmacology (Frontiers Media S.A.) China, 07 May 2021

Pharmacology, Neuroscience

Key words: Ischemic Stroke, Notoginsenoside R1, Neurogenesis, Neurological Recovery, Oligodendrogenesis [more]

The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice

YL Wang, YH Lee, YH Hsu, IJ Chiu, CCY Huang, CC Huang, ZC Chia, CP Lee, YF Lin, HW Chiu

Environmental Health Perspectives (National Institute of Environmental Health Sciences) Taiwan, 06 May 2021

Toxicology,Nephrology

[more]

Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration

O Guillermin, N Angelis, CM Sidor, R Ridgway, A Baulies, A Kucharska, P Antas, MR Rose, J Cordero, O Sansom, VSW Li, BJ Thompson

EMBO Journal (EMBO press) UK, Australia, 05 May 2021

Regenerative Medicine

[more]

In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

D Biagi, ET Fantozzi, JC Campos-Oliveira, MV Naghetini, AF Ribeiro Jr, S Rodrigues, I Ogusuku, R Vanderlinde, M Lopes Araújo Christie, D Bastos Mello, AC Campos de Carvalho, M Valadares, E Cruvinel, R Dariolli

Journal of Personalized Medicine (MDPI) Brazil, Germany, USA, 04 May 2021

Cardiology, Stem Cell Research

Key words: Stem Cell-Therapy, Human Induced Pluripotent Stem Cells, Cardiomyocytes, Myocardial Infarction, Heart Failure, Regeneration, Cardiac Function [more]

Effects of inverted photoperiods on the blood pressure and carotid artery of spontaneously hypertensive rats and Wistar–Kyoto rats

YL Wang, T Zhang, YG Zhang, Y Yu, F Bai, H Zhang, YF Chi

Journal of Hypertension (LWW Journals) China, 01 May 2021

Cardiology

Key words: Arterial Thrombosis, Atherosclerosis, Hypertension, Inverted Photoperiod [more]

CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation

R Ajoy, YC Lo, MH Ho, YY Chen, Y Wang, YH Chen, C Jing-Yuan, CA Changou, YC Hsiung, HM Chen, TH Chang, CY Lee, YH Chiang, WC Chang, B Hoffer, SY Chou

Molecular Psychiatry (Nature) Taiwan, USA, 30 April 2021

Neuroscience

Key words: Neuroscience, Physiology [more]

Development of a mechanically matched Silk Scaffolded 3D clear cell renal cell carcinoma model

A Abbott, K Bond, T Chiba, S Sims-Lucas, L Oxburgh, JM Coburn

Materials Science and Engineering: C (Elsevier) USA, 29 April 2021

Biological Materials

Key words: Scaffold, Mechanical Testing, Tissue Engineering, Cancer Modeling [more]

Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

M Muhuri, W Zhan, Y Maeda, J Li, A Lotun, J Chen, K Sylvia, I Dasgupta, M Arjomandnejad, T Nixon, AM Keeler, S Manokaran, R He, Q Su, PWL Tai, G Gao

Frontiers in Immunology (Frontiers Media S.A.) USA, 28 April 2021

Virology

Key words: Adeno-Associated Virus Vectors, microRNA, miR-BS, miR-142, miR-652-5p, miR-223-3p, Antigen Presenting Cells, Gene Therapy [more]

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

JH Choe, PB Watchmaker, MS Simic, RD Gilbert, AW Li, NA Krasnow, KM Downey, W Yu, DA Carrera, A Celli, J Cho, JD Briones, JM Duecker, YE Goretsky, R Dannenfelser, L Cardarelli, O Troyanskaya, SS Sidhu, KT Roybal, H Okada, WA Lim

Science Translational Medicine (AAAS) USA, Canada, 28 April 2021

Oncology

[more]

Minoxidil-coated lysozyme-shelled microbubbes combined with ultrasound for the enhancement of hair follicle growth: Efficacy in vitro and in vivo

AH Liao, YJ Huang, HC Chuang, CH Wang, CP Shih, CP Chiang

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 27 April 2021

Pharmacology

Key words: Ultrasound, Cavitation, Lysozyme-Shelled Microbubbles, Minoxidil, Hair Follicle [more]

Macrophages Inhibit Ciliary Protein Levels by Secreting BMP-2 Leading to Airway Epithelial Remodeling Under Cigarette Smoke Exposure

Z Wang, W Liang, C Ma, J Wang, X Gao, L Wie

Frontiers in Molecular Biosciences (Frontiers Media S.A.) China, 26 April 2021

Cell Biology

Key words: COPD, Cigarette Smoking, Macrophage, Bronchial Epithelial Cell, Ciliary Protein [more]

Cells in the gut

T Skrzypek, K Ferenc, M Domino, J Olszewski, R Zabielski

Atlas of the Pig Gut (Elsevier) Poland, 23 April 2021

Gastroenterology

Key words: Stem Cells, Enterocytes, Goblet Cells, Enteroendocrine Cells, M Cells, Tuft Cells, Interstitial Cells of Cajal, Myocytes

Magnetic Fluid Hyperthermia as Treatment Option for Pancreatic Cancer Cells and Pancreatic Cancer Organoids

J Palzer, B Mues, R Goerg, M Aberle, SS Rensen, SWM Olde Damink, RDW Vaes, T Cramer, T Schmitz-Rode, UP Neumann, I Slabu, AA Roeth

International Journal of Nanomedicine (Dovepress) Germany, The Netherlands, 23 April 2021

Nanomedicine, Oncology

Key words: Magnetic Nanoparticles, SPION, Pancreatic Cancer, PDAC, Organoids, Magnetic Fluid Hyperthermia [more]

Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study

D Morgante, A Radford, SK Abbas, E Ingham, R Subramaniam, J Southgate

Journal of Tissue Engineering (SAGE Journals) UK, 20 April 2021

Tissue Engineering

Key words: Acellular Matrix, Biomaterial, Surgery, Hypospadias Repair, Tissue Integration [more]

Exposure-time-dependent subcellular staging of gold nanoparticles deposition and vesicle destruction in mice livers

XM Wang, XW Wu, XY Zhao, CW Wang, JN Zhou

Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) China, 20 April 2021

Nanomedicine

Key words: Gold Nanoparticles, Biodistribution, Liver, Vesicle, Transmission Electron Microscopy [more]

Contribution of Genetic Background to the Radiation Risk for Cancer and Non-Cancer Diseases in Ptch1+/–Mice

I De Stefano, S Leonardi, A Casciati, E Pasquali, P Giardullo, F Antonelli, F Novelli, G Babini, M Tanori, B Tanno, A Saran, M Mancuso, S Pazzaglia

Radiation Research (Radiation Research Society) Italy, 15 April 2021

Oncology

Persistent expression of interleukin‐17 and downstream effector cytokines in recalcitrant psoriatic lesions after ustekinumab treatment

BR Kim, M Kim, S Yang, CW Choi, KS Lee, SW Youn

The Journal of Dermatology (Wiley) South Korea, 15 April 2021

Dermatology

Key words: Cytokines, Interleukin‐17, Interleukin‐23, Psoriasis, Ustekinumab [more]

Cardiac Protection by Oral Sodium Thiosulfate in a Rat Model of L-NNA-Induced Heart Disease

ITN Nguyen, LM Wiggenhauser, M Bulthuis, JL Hillebrands, M Feelisch, MC Verhaar, H van Goor, JA Joles

Frontiers in Pharmacology (Frontiers Media S.A.) The Netherlands, UK, 15 April 2021

Pharmacology

Key words: Hydrogen Sulfide, Hypertension, ACE-Inhibitor, Cardiovascular Disease, Nitric Oxide [more]

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

J Lv, Z Wang, Y Qu, H Zhu, Q Zhu, W Tong, L Bao, Q Lv, J Cong, D Li, W Deng, P Yu, J Song, WM Tong, J Liu, Y Liu, C Qin, B Huang

Cell discovery (Nature) China, 13 April 2021

SARS-CoV-2

Key words: Innate Immunity, Mechanisms of Disease [more]

Enhancing Anti-Tumoral Potential of CD-NHF by Modulating PI3K/Akt Axis in U87 Ex Vivo Glioma Model

G Luta, M Butura, A Tiron, CE Tiron

International Journal of Molecular Sciences (MDPI) Romania, 08 April 2021

Oncology

Key words: Glioblastoma, Anti-Cancer Agent, Carbon Dots, EMT, Nanomedicine [more]

Next-Generation Digital Histopathology of the Tumor Microenvironment

F Mungenast, A Fernando, R Nica, B Boghiu, B Lungu, J Batra, RC Ecker

Genes (MDPI) Austria, Australia, Romania, 07 April 2021

Medical Image Analysis

Key words: Next-Generation Digital Histopathology, Tissue Cytometry, Multiplexing, RNA ISH, Cancer, Tumor Immune Microenvironment, Tumor Microenvironment

Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

SH Park, K Fong, J Kim, F Wang, X Lu, Y Lee, LT Brea, K Wadosky, C Guo, SA Abdulkadir, JD Crispino, D Fang, P Ntziachristos, X Liu, X Li, Y Wan, DW Goodrich, JC Zhao, J Yu

Science Advances (AAAS) USA, 07 April 2021

Oncology

[more]

Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model

MA Plantz, S Minardi, JG Lyons, AC Greene, DJ Ellenbogen, M Hallman, JT Yamaguchi, S Jeong, C Yun, AE Jakus, KR Blank, RM Havey, M Muriuki, AG Patwardhan, RN Shah, WK Hsu, SR Stock, EL Hsu

Acta Biomaterialia (Elsevier) USA, 06 April 2021

Biological Materials

Key words: 3D Printing, Hydroxyapatite, Demineralized Bone Matrix, Bone Regeneration, Spine Fusion [more]

Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome

HJ Shih, CY Chang, CH Lai, CJ Huang

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 01 April 2021

Pharmacology

Key words: Inflammation, Bladder, Inflammasome, Curcumin, Fibrosis [more]

Human skin aging is associated with increased expression of the histone variant H2A. J in the epidermis

CE Rübe, C Bäumert, N Schuler, A Isermann, Z Schmal, M Glanemann, C Mann, H Scherthan

npj Aging and Mechanisms of Disease (Nature) Germany, France, 01 April 2021

Aging

Key words: Aging, Epigenetics [more]

Single-cell sequencing reveals the transcriptome and TCR characteristics of pTregs and in vitro expanded iTregs

Z Hui, J Zhang, Y Zheng, L Yang, W Yu, Y An, F Wie, Y Ren

Frontiers in Immunology (Frontiers Media S.A.) China, 31 March 2021

Immunology

Key words: Single-Cell Sequencing, In Vitro, Regulatory T Cells, Colorectal Cancer, Chemokine Receptors [more]

n-Butyl Benzyl Phthalate Exposure Promotes Lesion Survival in a Murine Endometriosis Model

P Sharma, JYL Lee, EM Tsai, Y Chang, JJ Suen

International Journal of Environmental Research and Public Health (MDPI) Taiwan, 31 March 2021

Reproductive Medicine

Key words: N-Butyl Benzyl Phthalate, CD44, Dendritic Cell, Endometriosis [more]

Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen

A Dievernich, P Achenbach, L Davies, U Klinge

Hernia (Springer) Germany, UK, 31 March 2021

Immunology, Tissue Engineering

Key words: Foreign Body Reaction, Adaptive Immune System, Innate Immune System, Mesh, Fluorescence Microscopy [more]

Therapeutic Effect of Cinnamomum osmophloeum Leaf Extract on Oral Mucositis Model Rats Induced by 5-Fluororacil via Influencing IL-1β and IL-6 Levels

A Bakar, V Ningrum, SC Lee, CT Li, CW Hsieh, SH Wang, MS Tsai

Processes (MDPI) Indonesia, Taiwan, 31 March 2021

Pharmacology

Key words: Cinnamomum Osmophloeum, Oral Mucositis, Model Rat, 5-Fluororacil, IL-1β, IL-6 [more]

Hypoxia and oxidative stress induce sterile placental inflammation in vitro

BC Baker, AEP Heazell, C Sibley, R Wright, H Bischof, F Beards, T Guevara, S Girard, RL Jones

Scientific Reports (Nature) UK, Canada, 31 March 2021

Reproductive Medicine

Key words: Developmental Biology, Diseases, Immunology, Medical Research, Pathogenesis [more]

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

M Delacher, M Simon, L Sanderink, A Hotz-Wagenblatt, M Wuttke, K Schambeck, L Schmidleithner, S Bittner, A Pant, U Ritter, T Hehlgans, D Riegel, V Schneider, FK Groeber-Becker, A Eigenberger, C Gebhard, N Strieder, A Fischer, M Rehli, P Hoffmann, M Edinger, T Strowig, J Huehn, C Schmidl, JM Werner, L Prantl, B Brors, CD Imbusch, M Feuerer

Immunity (Cell Press) Germany, 30 March 2021

Immunology

[more]

Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia

O Nonn, C Fischer, S Geisberger, A El-Heliebi, T Kroneis, D Forstner, G Desoye, AC Staff, M Sugulle, R Dechend, U Pecks, M Kollmann, C Stern, JE Cartwright, GS Whitley, B Thilaganathn, C Wadsack, B Huppertz, F Herse, M Gauster

Hypertension (American Heart Association) Austria, Germany, Norway, UK, 29 March 2021

Reproductive Medicine

Key words: Candesartan, Leptin, Oxygen, Respiration, Trophoblasts [more]

Expression of CD9 on porcine lymphocytes and its relation to T cell differentiation and cytokine production

JV Milburn, A Hoog, S Winkler, KA van Dongen, J Leitner, M Patzl, A Saalmüller, K de Luca, P Steinberger, KH Mair, W Gerner

Developmental & Comparative Immunology (Elsevier) Austria, France, 27 March 2021

Immunology

Key words: Tetraspanin, CD9, Porcine, Lymphocyte, Memory [more]

Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia

L Morales-Nebreda, KA Helmin, MAT Acosta, NS Markov, JY Hu, AM Joudi, R Piseaux-Aillon, H Abdala-Valencia, Y Politanska, BD Singer

JCI Insight (The American Society for Clinical Investigation) USA, 22 March 2021

Aging

Key words: Aging, T Cells [more]

Selective Denervation of the Facial Dermato-Muscular Complex in the Rat: Experimental Model and Anatomical Basis

V Tereshenko, DC Dotzauer, U Maierhofer, C Festin, M Luft, G Laengle, O Politikou, HJ Klein, R Blumer, OC Aszmann, KD Bergmeister

Frontiers in Neuroanatomy (Frontiers Media S.A.) Austria, Switzerland, 22 March 2021

Neuroscience

Key words: Facial Nerve, Trigeminal Nerve, Motor-Sensory Control, Facial Muscles, Axon Quantification, Whole-Mount Staining [more]

Inhibition of vascular adhesion protein‐1 enhances the anti‐tumor effects of immune checkpoint inhibitors

T Kinoshita, MA Sayem, T Yaguchi, B Kharma, K Morii, D Kato, S Ohta, Y Mashima, H Asamura, Y Kawakami

Cancer Science (Japanese Cancer Association) Japan, Bangladesh, 18 March 2021

Oncology

Key words: CTLs, H2O2, ICIs, Immunosuppression, VAP‐1 Inhibitor [more]

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

W Cui, D Liu, W Gu, B Chu

Cell Death & Differentiation (Nature) China, USA, 17 March 2021

Oncology

Key words: Cancer Metabolism, Phospholipids [more]

Luteolin Modulates the NF-E2-Related Factor 2/Glutamate–Cysteine Ligase Pathway in Rats with Spinal Cord Injury

J Fu, W Xu, Y Zhang, H Sun, J Zhao

Journal of Medicinal Food (Mary Ann Liebert Inc.) China, 16 March 2021

Neuroscience

Key words: Luteolin, Nrf2/GCL Pathway, Oxidative Stress, Spinal Cord Injury [more]

Machine perfused donor kidneys as a source of human renal endothelial cells

RGM Lammerts, LM Lagendijk, G Tiller, WA Dam, HL Lancaster, MR Daha, MA Seelen, BG Hepkema, RA Pol, HGD Leuvenink, G Molema, J van den Born, SP Berger, the COMBAT Consortium

American Journal of Physiology (APS Journals) The Netherlands, 15 March 2021

Nephrology

Key words: Kidney, Transplantation, Endothelial Cells, Machine Perfusion, Perfusate [more]

Genetic Drivers of Head and Neck Squamous Cell Carcinoma: Aberrant Splicing Events, Mutational Burden, HPV Infection and Future Targets

Z Dlamini, M Alaouna, S Mbatha, A Bhayat, M Mabongo, A Chatziioannou, R Hull

Genes (MDPI) South Africa, Greece, 15 March 2021

Oncology

Key words: Head and Neck Squamous Cell Carcinoma (HNSCC), Aberrant Splicing Events, Human Papillomavirus (HPV) Infection, Non-Coding RNA (ncRNA), Methylation, Mutational Burden [more]

A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice

HL Lee, SW Hee, CF Hsuan, W Yang, JY Huang, YL Lin, CN Hsu, JJ Hwang, SM Chen, ZZ Ding, TY Lee, YC Lin, FC Tsai, WL Su, LY Chueh, ML Hsieh, CH Chen, D Mochly-Rosen, YC Chang, LM Chuang

Antioxidants (MDPI) Taiwan, USA, 13 March 2021

Cardiology, Endocrinology

Key words: Diabetic Cardiomyopathy, 4-Hydroxy-2-Nonenal, Mitochondrial Aldehyde Dehydrogenase 2, AD-9308 [more]

MicroRNA-126 inhibits pathological retinal neovascularization via suppressing vascular endothelial growth factor expression in a rat model of retinopathy of prematurity

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

European Journal of Pharmacology (Elsevier) Taiwan, 13 March 2021

Pharmacology

Key words: miR-126, Retinal Pigment Epithelium Cells, Vascular Endothelial Growth Factor, Oxygen-Induced Retinopathy, Neovascularization, Rat [more]

N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice

GG Liou, CC Hsieh, YJ Lee, PH Li, MS Tsai, CT Li, SH Wang

Antioxidants (MDPI) Taiwan, 12 March 2021

Hepathology

Key words: Acetaminophen Overdose, N-Acetyl Cysteine Overdose, Two Inbred Mouse Strains, Hepatic Inflammation, Systemic Inflammation, Microvesicular Steatosis [more]

Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis

GF Rani, O Preham, H Ashwin, N Brown, IS Hitchcock, PM Kaye

Blood Advances (ASH Publications) UK, 12 March 2021

Immunology

Key words: Blood Platelets, Infections, Leishmania Donovani, Leishmaniasis, Visceral, Mice, Thrombocytopenia, Drug Clearance, Thrombopoietin, Spleen, Liver [more]

CHPF Regulates the Aggressive Phenotypes of Hepatocellular Carcinoma Cells via the Modulation of the Decorin and TGF-β Pathways

CH Liu, BR Wu, YJ Ho, YH Chu, WC Hsu, TJ Tseng, JP Li, WC Liao

Cancers (MDPI) Taiwan, 12 March 2021

Oncology

Key words: Hepatocellular Carcinoma, Tumor Microenvironment, Chondroitin Polymerizing Factor, Chondroitin Sulfate, Decorin [more]

KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma

J Ingruber, D Savic, TB Steinbichler, S Sprung, F Fleischer, R Glueckert, G Schweigl, II Skvortsova, H Riechelmann, J Dudás

Cells (MDPI) Austria, 12 March 2021

Oncology

Key words: TissueFaxs, TWIST, ZEB, SCC-25, FaDu, UPCI-SCC090 [more]

Dietary Modification Alters the Intrarenal Immunologic Micromilieu and Susceptibility to Ischemic Acute Kidney Injury

J Jeon, K Lee, KE Yang, JE Lee, GY Kwon, W Huh, DJ Kim, YG Kim, HR Jang

Frontiers in Immunology (Frontiers Media S.A.) South Korea, 11 March 2021

Immunology, Nephrology

Key words: Diet, High-Salt Diet, High-Fat Diet, Acute Kidney Injury, Immunologic Micromilieu, Ischemia-Reperfusion Injury [more]

Genome-wide 5-hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer

SL Wu, X Zhang, M Chang, C Huang, J Qian, Q Li, F Yuan, L Sun, X Yu, X Cui, J Jiang, M Cui, Y Liu, HW Wu, ZYLiang, X Wang, Y Niu, WM Tong, F jin

Genomics, Proteomics & Bioinformatics (Elsevier) China, 11 March 2021

Proteomics, Oncology

Key words: 5-Hydroxymethylcytosine (5hmC), Breast Cancer, Lymph Node Metastasis, MAP7D1, Biomarker [more]

A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma

P Kumthekar, CH Ko, T Paunesku, K Dixit, AM Sonabend, O Bloch, M Tate, M Schwartz, L Zuckerman, R Lezon, RV Lukas, B Jovanovic, K McCortney, H Colman, S Chen, B Lai, O Antipova, J Deng, L Li, S Tommasini-Ghelfi, LA Hurley, D Unruh, NV Sharma, M Kandpal, FM Kouri, RV Davuluri, DJ Brat, M Muzzio, M Glass, V Vijayakumar, J Heidel, FJ Giles, AK Adams, CD James, GE Woloschak, C Horbinski, AH Stegh

Science Translational Medicine (AAAS) USA, 10 March 2021

Oncology

[more]

Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production

X Chen, C Wang, N Sun, S Pan, R Li, X Li, J Zhao, H Tong, Y Tang, J Han, J Qiao, H Qiu, H Wang, J Yang, T Ikezoe

Theranostics (Ivyspring International Publisher) China, Japan, 04 March 2021

Cell Biology

Key words: Aurora-A, Thrombopoietin, STAT3, IL-6, Megakaryocytopoiesis. [more]

CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment

WC Liao, HR Yen, CH Chen, YH Chu, YC Song, TJ Tseng, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 01 March 2021

Oncology

Key words: Breast Cancer, Chondroitin Sulfate, CHPF, Tumor Microenvironment, Syndecan-4 [more]

Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury

S Yang, T Hu, H Liu, Y Lv, W Zhang, H Li, L Xuan, LL Gong, LH Liu

Biomedicine & Pharmacotherapy (Elsevier) China, USA, 27 February 2021

Gastroenterology

[more]

Parathyroid hormone induces transition of myofibroblasts in arteriovenous fistula and increases maturation failure

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, FY Lin, CM Shih, YT Shiu, PH Huang

Endocrinology (Oxford Academic) Taiwan, USA, 26 February 2021

Endocrinology

Key words: Arteriovenous Fistula (AVF), Fibrosis, Hemodialysis, Parathyroid Hormone (PTH) [more]

Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

N Samadi, D Heiden, M Klems, M Salzmann, J Rohrhofer, E Weidmann, L Koidl, E Jensen-Jarolim, E Untersmayr

Nutrients (MDPI) Austria, 26 February 2021

Allergy Research

Key words: Food Allergy, Gastric Enzymes, Gastric Acid Suppression, Systemic Allergic Response, Allergy Prevention [more]

Genetic Background Effects on the Expression of an Odorant Receptor Gene

AG Leme Silva, MH Nagai, TS Nakahara, B Malnic

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) Brazil, 25 February 2021

Neuroscience

Key words: DNA Methylation, Odorant Receptor Gene, Olfactory Receptor Gene, Genetic Background, Gene Expression, Single Nucleotide Polymorphism [more]

Regulation of pancreatic fibrosis by acinar cell-derived exosomal miR-130a-3p via targeting of stellate cell PPAR-γ

Q Wang, H Wang, Q Jing, Y Yang, D Xue, C Hao, W Zhang

Journal of Inflammation Research (Dovepress) China, 24 February 2021

Gastroenterology

Key words: Pancreatitis, Exosomes, miR-130a-3p, Pancreatic Fibrosis, PPAR- γ [more]

Pollen grain microscopic image classification using an ensemble of fine-tuned deep convolutional neural networks

A Mahbod, G Schaefer, R Ecker, I Ellinger

International Conference on Pattern Recognition (Springer) Austria, UK, 21 February 2021

Machine Learning

Key words: Medical Image Analysis

Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

C Hui, H Bai, J Liu, X Lu, S Wang, Z Zhang, M Jin, Y Wang, Y Liu

Diagnostic Pathology (Springer) China, 19 February 2021

Pathology

Key words: Cervical Intraepithelial Neoplasia, CIN, Diagnostic Accuracy, E6/E7 mRNA, In Situ Hybridization [more]

T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells

Abigail E Schiff, Alice H Linder, Shillah N Luhembo, Stephanie Banning, Martin J Deymier, Thomas J Diefenbach, Amy K Dickey, Athe M Tsibris, Alejandro B Balazs, Josalyn L Cho, Benjamin D Medoff, Gerhard Walzl, Robert J Wilkinson, Wendy A Burgers, Björn Corleis, Douglas S Kwon

Scientific Reports (Nature) USA, South Africa, UK, Germany, 16 February 2021

Virology

Key words: HIV Infections, Monocytes and Macrophages, Mucosal Immunology, Retrovirus, Virology, Virus–Host Interactions [more]

Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness

J Ning, Y Ye, D Bu, G Zhao, T Song, P Liu, W Yu, H Wang, H Li, X Ren, G Ying, Y Zhao, J Yu

Molecular Therapy (Elsevier) China, 15 February 2021

Oncology

[more]

Curcumin inhibits the growth of liver cancer by impairing myeloid‑derived suppressor cells in murine tumor tissues

S Tian, L Liao, Q Zhou, X Huang, P Zheng, Y Guo, T Deng, X Tian

Oncology Letters (Spandidos Publications) China, 12 February 2021

Oncology

[more]

Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4

T Guo, YH Bai, XJ Cheng, HB Han, H Du, Y Hu, SQ Jia, XF Xing, JF Ji

Cancer Communications (Wiley) China, 11 February 2021

Oncology

Key words: Gastric Cancer, Glucose Transporter 4, Glycolysis, Insulin Gene Enhancer Protein 1, Tumorigenesis [more]

Global Analysis of Lysine Acetylome Reveals the potential role of CCL18 in non‐small cell lung cancer

S Kong, L Ding, C Fan, Y Li, C Wang, K Wang, W Xu, X Shi, Q Wu, F Wang

Proteomics (Wiley) China, 11 February 2021

Proteomics

Key words: Acetylome, CCL18, Non-Small Cell Lung Cancer [more]

Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms

Wolf Eilenberg, Branislav Zagrapan, Sonja Bleichert, Nahla Ibrahim, Viktoria Knöbl, Annika Brandau, Luca Martelanz, Marie-Therese Grasl, Hubert Hayden, Paimann Nawrozi, Renata Rajic, Charlotte Häusler, Alexandros Potolidis, Nawa Schirwani, Andreas Scheuba, Johannes Klopf, Peter Teubenbacher, Markus P Weigl, Patrick Kirchweger, Dietrich Beitzke, Alexander Stiglbauer-Tscholakoff, Adelheid Panzenböck, Irene Lang, Lisa-Marie Mauracher, Lena Hell, Ingrid Pabinger, Marc A Bailey, D Julian A Scott, Lars Maegdefessel, Albert Busch, Ihor Huk, Christoph Neumayer, Christine Brostjan

Translational Research (Elsevier) Austria, UK, Sweden, 09 February 2021

Cardiology

[more]

IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer

G Jordakieva, R Bianchini, D Reichhold, J Piehslinger, A Groschopf, SA Jensen, E Mearini, G Nocentini, R Crevenna, GJ Zlabinger, SN Karagiannis, A Klaus, E Jensen-Jarolim

OncoImmunology (Taylor & Francis) Austria, Italy, UK, 08 February 2021

Oncology

Key words: IgG4, IgE, Tumor-Associated Macrophages, M2b, Allergooncology [more]

Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice

JH Liu, CH Hsieh, CY Liu, CW Chang, YJ Chen, TH Tsai

Journal of Ethnopharmacology (Elsevier) Taiwan, 07 February 2021

Pharmacology

Key words: 5-Fluorouracil (5-FU), Radix Aucklandiae, Intestinal Mucositis, Goblet Cell, Anti-Inflammatory [more]

Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment

SC Chang, BX Zhang, ECY Su, WC Wu, TH Hsieh, AM Salazar, YK Lin, JL Ding

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Singapore, 05 February 2021

Oncology

Key words: NSCLC (Non-Small Cell Lung Cancer), Combinatorial Treatment with Hiltonol+++ Cocktail [Hiltonol+Anti-IL6+Stattic+AG490], Tumorigenic Microenvironment, Anti- and Pro-Tumorigenic Cytokine Production, Tumor-Suppressors PKR (Protein Kinase R) And OAS (2′5′ Oligoadenylate Synthetase) [more]

H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice.

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 05 February 2021

Neuroscience

Key words: Chronic Stress Stimulated Depression Model, Hippocampus, Hydrogen Sulfide, Inflammatory, Aerobic Exercise [more]

Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

E Nguyen, G Lim, H Ding, J Hachisuka, MC Ko, SE Ross

Science Translational Medicine (AAAS) USA, UK, 03 February 2021

Neuroscience

[more]

Expression of chondroitin sulfate proteoglycan 4 (CSPG4) in melanoma cells is downregulated upon inhibition of BRAF

K Uranowska, T Kalic, V Valtsanidis, M Kitzwögerer, H Breiteneder, C Hafner

Oncology Reports (Spandidos Publications) Austria, 02 February 2021

Oncology

[more]

Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer

J Yang, A Eresen, J Shangguan, Q Ma, V Yaghmai, Z Zhang

OncoImmunology (Taylor & Francis) USA, 02 February 2021

Oncology

Key words: Irreversible Electroporation, Dendritic Cell Vaccine, Pancreatic Ductal Adenocarcinoma, Magnetic Resonance Imaging [more]

iTRAQ-based Quantitative Proteomic Analysis of Dural Tissues Reveals Upregulated Haptoglobin to be a Potential Biomarker of Moyamoya Disease

X Zhang, L Yin, X Jia, Y Zhang, T Liu, L Zhang

Current Proteomics (ingentaconnect) China, 01 February 2021

Proteomics

Key words: Moyamoya Disease, Dura Mater, Proteomics, iTRAQ, Haptoglobin, Strokes

Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer

LR Heij, X Tan, JN Kather, JM Niehues, S Sivakumar, N Heussen, G van der Kroft, SWM Olde Damink, S Lang, MR Aberle, T Luedde, NT Gaisa, J Bednarsch, DHW Liu, JPM Cleutjens, DP Modest, UP Neuman, GJ Wiltberger

Journal of Clinical Medicine (MDPI) Germany, The Netherlands, UK, Austria, 30 January 2021

Oncology

Key words: Tumor Microenvironment, Machine Learning, Nerve Fiber Density, Spatial Arrangements, Tertiary Lymphoid Structures, Pancreatic Cancer [more]

Endothelial-Derived miR-17∼ 92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury

T Chiba, DM Cerqueira, Y Li, AJ Bodnar, E Mukherjee, K Pfister, YL Phua, K Shaikh, BT Sanders, SL Hemker, PJ Pagano, YL Wu, J Ho, S Sims-Lucas

Journal of The American Society of Nephrology (Am Soc Nephrol) USA, 29 January 2021

Nephrology

Key words: microRNA, Acute Kidney Injury, Renal Microvasculature [more]

Mer tyrosine kinase (MerTK) as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease

L Rovati, N Kaneko, F Pedica, A Monno, T Maehara, C Perugino, M Lanzillotta, S Pecetta, JH Stone, C Doglioni, AA Manfredi, S Pillai, E Della-Torre

Rheumatology (Oxford Academic) Italy, USA, Japan, 29 January 2021

Rheumatology

Key words: IgG4-Related Disease, Macrophages, MerTK, Protein S, Fibrosis [more]

Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression

M Lenz, C Kaun, KA Krychtiuk, P Haider, M Brekalo, N Maier, L Goederle, CJ Binder, K Huber, C Hengstenberg, J Wojta, PJ Hohensinner, WS Speidl

Biomedicines (MDPI) Austria, 27 January 2021

Cardiology

Key words: Nicorandil, Inflammation, Apoptosis, Atherosclerosis, Plaque, Plaque Stabilization [more]

Interleukin-24 protects against liver injury in mouse models

HH Wang, JH Huang, MH Sue, WC Ho, YH Hsu, KC Chang, MS Chang

EBioMedicine (THE LANCET) Taiwan, 25 January 2021

Hepathology

Key words: Interleukin-24, Liver Fibrosis, Thioacetamide-Induced Liver Injury, Hepatic Stellate Cells [more]

Immune Modulation Effects of Lactobacillus casei Variety rhamnosus on Enterocytes and Intestinal Stem Cells in a 5-FU-Induced Mucositis Mouse Model

CY Yeung, JSC Chiau, ML Cheng, WT Chan, SW Chang, CB Jiang, HC Lee

Gastroenterology Research and Practice (Hindawi Publishing Corporation) Taiwan, 25 January 2021

Gastroenterology

[more]

A Hepatitis B Virus-Derived Peptide Exerts an Anticancer Effect via TNF/iNOS-producing Dendritic Cells in Tumor-Bearing Mouse Model

SB Yang, MH Lee, BR Kim, YM Choi, BJ Kim

Cancers (MDPI) South Korea, 22 January 2021

Oncology

Key words: HBV-Derived Poly6 Peptide, TNF/ iNOS-Producing DCs (Tip-DCs), Type 1 Interferon (IFN-I), CD40, Cancer Immunotherapy [more]

Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner

Y Li, S Li, Y Zhang, S Shi, S Qin, C Wang, J Du, J Ma, H Chen, H Cui

Journal of Cancer (Ivyspring International Publisher) China, 21 January 2021

Oncology

Key words: Ovarian Carcinoma, Androgen Receptor (AR), Tissue Microarray (TMA), Proliferation Promotion, PI3K/AKT Signalling Pathway [more]

Performance and Meat Quality of Intrauterine Growth Restricted Pigs

P Matyba, T Florowski, K Dasiewicz, K Ferenc, J Olszewski, M Trela, G Galemba, M Słowiński, M Sady, D Domańska, Z Gajewski, R Zabielski

Animals (MDPI) Poland, 20 January 2021

Zoology

Key words: IUGR, Pigs, Growth Performance, Meat Quality, Sensory Evaluation [more]

Pathological Pulmonary Vascular Remodeling is Induced by Type V Collagen in a Model of Scleroderma

RG Marangoni, BD Korman, ER Parra, APP Velosa, HV Barbeiro, V Martins, ABG dos Santos, F Soriano, WR Teodoro, PL Silva, W Tourtellotte, VL Capelozzi, J Varga, NH Yoshinari

Pathology-Research and Practice (Elsevier) Brazil, USA, 19 January 2021

Cardiology

Key words: Animal Model, Scleroderma, Collagen V, Vascular Disease, Endothelium [more]

Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections

HY Park, SD Zoller, V Hegde, W Sheppard, Z Burke, G Blumstein, C Hamad, M Sprague, J Hoang, R Smith, FR Pastrana, J Czupryna, LS Miller, M López-Álvarez, M Bispo, M van Oosten, J Maarten van Dijl, KP Francis, NM Bernthal

Scientific Reports (Nature) USA, The Netherlands, 15 January 2021

Medical Imaging

Key words: Biofilms, Infectious Diseases [more]

PEG-GO@ XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to …

J Zhang, L Yan, P Wei, R Zhou, C Hua, M Xiao, Y Tu, Z Gu, T Wei

European Journal of Pharmacology (Elsevier) China, USA, 14 January 2021

Oncology, Nanomedicine

Key words: Graphene Oxide, Xanthohumol, Breast Cancer Metastasis, Mitochondria, Epithelial-Mesenchymal Transition, Energy Metabolism [more]

Macromolecular crowding as a tool to screen anti-fibrotic drugs: the Scar-in-a-Jar system revisited

NP Cavanzo, E Bigaeva, M Boersema, P Olinga, RA Bank

Frontiers in Medicine (Frontiers Media S.A.) The Netherlands, China, USA, Switzerland, 14 January 2021

Biological Methods

Key words: Macromolecular Crowding, Drug Testing, Fibrosis, Collagen, Myofibroblast [more]

Mesenchymal stem cell‐glioblastoma interactions mediated via kinin receptors unveiled by cytometry

MM Pillat, Á Oliveira‐Giacomelli, M das Neves Oliveira, R Andrejew, N Turrini, J Baranova, TL Turnšek, H Ulrich

Cytometry Part A (Wiley) Brazil, 13 January 2021

Medical Image Analysis

Key words: Cytometry, Glioblastoma, Kinin Receptors, Kinin‐B1 Receptor, Kinin‐B2 Receptor, Mesenchymal Stem Cells [more]

Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

YY Wang, B Zhao, MM Wu, XL Zheng, L Lin, DM Yin

Nature Communications (Nature) China, 12 January 2021

Neuroscience

Key words: Molecular Neuroscience, Schizophrenia [more]

Stem Cell-Derived Respiratory Epithelial Cell Cultures as Human Disease Models

JC Orr, RE Hynds

American Journal of Respiratory Cell and Molecular Biology (Wiley) UK, 11 January 2021

Stem Cell Research

Key words: Respiratory Epithelium, Epithelial Cells, Cell Culture, Cloning, Stem Cells

Overexpression of GLUT3 promotes metastasis of triple‐negative breast cancer by modulating the inflammatory tumor microenvironment

TH Tsai, CC Yang, TC Kou, CE Yang, JZ Dai, CL Chen, CW Lin

Journal of Cellular Physiology (Wiley) Taiwan, 09 January 2021

Oncology

Key words: Glycolysis, Inflammation, Triple‐Negative Breast Cancer, Tumor Microenvironment, Tumor‐Associated Macrophage [more]

Development and Validation of Sorafenib-eluting Microspheres to Enhance Therapeutic Efficacy of Transcatheter Arterial Chemoembolization in a Rat Model of of Hepatocellular Carcinoma

W Park, S Cho, J Ji, RJ Lewandowski, AC Larson, DH Kim

Radiology: Imaging Cancer (Royal Society of Chemistry) USA, 08 January 2021

Oncology

[more]

Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

C Bangert, K Rindler, T Krausgruber, N Alkon, FM Thaler, H Kurz, T Ayub, D Demitras, N Fortelny, V Vorstandlechner, WM Bauer, T Quint, M Mildner, C Jonak, A Elbe-Bürger, J Griss, C Bock, PM Brunner

Science Immunology (Science) Austria, 08 January 2021

Immunology, Dermatology

[more]

Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression.

IZA Pawluczyk, A Didangelos, SJ Barbour, L Er, JU Becker, R Martin, S Taylor, JS Bhachu, EG Lyons, R Jenkins, D Fraser, K Molyneux, J Perales-Paton, J Saez-Rodriguez, J Barratt

Kidney International (Elsevier) UK, Canada, Germany, Spain, 06 January 2021

Nephrology

Key words: IgA Nephropathy, microRNA [more]

Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1

Z Liu, L Sun, Y Cai, S Shen, T Zhang, N Wang, G Wu, W Ma, ST Li, C Suo, Y Hao, WD Jia, GL Semenza, P Gao, H Zhang

Cancer Research (AACR Publications) China, USA, 05 January 2021

Oncology

Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation

Tolani F Olonisakin, Tomeka Suber, Shekina Gonzalez-Ferrer, Zeyu Xiong, Hernán F Peñaloza, Rick van der Geest, Yuting Xiong, David O Osei-Hwedieh, Jesús Tejero, Matthew R Rosengart, Wendy M Mars, Daria Van Tyne, Andreas Perlegas, Samuel Brashears, Daniel B Kim-Shapiro, Mark T Gladwin, Michael A Bachman, Eldad A Hod, Claudette St Croix, Yulia Y Tyurina, Valerian E Kagan, Rama K Mallampalli, Anuradha Ray, Prabir Ray, Janet S Lee

The Journal of Clinical Investigation (American Society of Clinical Investigation) USA, 04 January 2021

Immunology

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