Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3476 papers published)

Results 3231 - 3240 of 3476
3231
1109 Density and Organization of B Cells, Including the Activation-induced Cytidine Deaminase (AID)-positive Sub-population, Within Active Tumor Border of Human Colorectal Cancer Liver Metastases Shows a Positive Association With Survival Prognosis

A Meshcheryakova, M Svoboda, E Bajna, J Maresch, J Jensen-Jarolim, M Bergmann, D Tamandl, D Mechtcheriakova

European Journal of Cancer (Elsevier) , 06 July 2012

Oncology

3232
1108 Histidine-rich Glycoprotein Regulates Macrophage Differentiation

O Noguer, S Tugues, S Honjo, L Claesson-Welsh

European Journal of Cancer (Elsevier) , 06 July 2012

Oncology

3233
Pristane-induced lupus as a model of human lupus arthritis: evolvement of autoantibodies, internal organ and joint inflammation

H Leiss, B Niederreiter, T Bandur, B Schwarzecker, S Blüml, G Steiner, W Ulrich3, JS Smolen, GH Stummvoll

Lupus (SAGE Journals) Austria , 01 July 2012

Rheumatology

Key words: Lupus arthritis pristane-induced lupus (PIL), systemic lupus erythematosus (SLE)

Organism: Mouse

Tissue: Joint Tissue, Bone, Lung, Kidney

Pathological State: Arthritis, Lupus

3234
A Novel Nucleus-Based Classifier for Discrimination of Osteoclasts and Mesenchymal Precursor Cells in Mouse Bone Marrow Cultures

Andreas Heindl, Alexander K Seewald, Martin Schepelmann, Radu Rogojanu, Giovanna Bises, Theresia Thalhammer, and Isabella Ellinger

International Journal of Medical and Health Sciences (Open Science Index) Austria , 01 July 2012

Osteology

Key words: osteoclasts, machine learning, ellipse fitting.

3235
RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas

Maciej Tarnowski, Gabriela Schneider, Gabriele Amann, Geoffrey Clark, Peter Houghton, Frederic G Barr, Lukas Kenner, Mariusz Z Ratajczak, Magda Kucia

International Journal of Oncology (Spandidos Publications) USA, Austria, Poland , 28 June 2012

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

3236
Cisplatin and quantum dots encapsulated in liposomes as multifunctional nanocarriers for theranostic use in brain and skin

Li-Wen Zhang, Chih-Jen Wen, Saleh A Al-Suwayeh, Tzu-Chen Yen, Jia-You Fang

Journal of Nanoparticle Research (Springer) Taiwan, Saudi Arabia , 19 June 2012

Nanomedicine

Key words: Cdse zns qds, cdse zns nanocrystal, nude mouse skin, cdse zns quantum, cisplatin release, mouse skin section, blank liposome, cdse core, skin melanoma, vesicle size, quantum dot, entrapment efficiency, skin uptake, non-treatment group, cisplatin accumulation

Organism: Mouse

Tissue: Brain, Skin

3237
Monitoring neutrophils and platelets during casein-induced anaphylaxis in an experimental BALB/c mouse model

D Krishnamurti, P Starkl, K Szalai, F Roth-Walter, S C Diesner, M Mittlboeck, C Manhalter, E Untersmayr, E Jensen-Jarolim

Clinical and Experimental Allergy (Wiley) Austria , 15 June 2012

Allergy Research

Key words: Mast cells, basophils, alum-adsorbed casein, peripheral neutropenia

3238
Quantitative analysis of binding sites for 9-fluoropropyl-(+)-dihydrotetrabenazine ([18F]AV-133) in a MPTP-lesioned PD mouse model

Ko-Ting Chao, Hsin-Hsin Tsao, Yi-Hsin Weng, Ing-Tsung Hsiao, Chia-Ju Hsieh, Shiaw-Pyng Wey, Tzu-Chen Yen, Mei-Ping Kung,Kun-Ju Lin

Synapse (Wiley) Taiwan , 13 June 2012

Neuroscience

Key words: Positron emission tomography, quantitative autoradiography, immunohistochemistry, vesicular monoamine transporter 2, standardized uptake value

Organism: Mouse

Tissue: Brain

Pathological State: Parkinson's Disease

3239
Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma

Renske A de Jong, Ido P Kema, Annemarie Boerma, H Marike Boezen, Johannes JL van der Want, Marloes JM Gooden, Harry Hollema, Hans W Nijman

Gynecologic Oncology (Elsevier) The Netherlands , 02 June 2012

Oncology

Key words: Endometrial carcinoma, indoleamine 2, 3-dioxygenase, T-lymphocytes, prognosis

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

3240
Evidence That Activated Hedgehog Signaling Predicts for Poor Clinical Outcome in Acute Myeloid Leukemia

Veronica Campbell, Eleni Tholouli, M Travis Quigley, John Keilty, Patrick Kelly, Karen McGovern, Margaret Read, Jeffery L Kutok, Richard Byers

Blood (American Society of Hematology) USA, UK , 01 June 2012

Oncology

Key words: Hedgehog (Hh), Acute Myeloid Leukemia (AML), Primary CD34+ myeloid blasts

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

Results 3231 - 3240 of 3476

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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